Development of Methods for Designing New Recombinants Producing Strains of Bacteria in Space Flight (Konyugatsia-EFR) - 08.05.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Kon'yugatsiya (Conjugation) studies the exchange of genetic material in microgravity in order to develop strains that can produce new target proteins.
Science Results for Everyone
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The following content was provided by Yu. P. Zerov, and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)
Yu. P. Zerov, Biopreparat, Russia

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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
April 2003 - October 2008

Expeditions Assigned

Previous ISS Missions
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Experiment Description

Research Overview
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Development of the methods for designing new recombinant producing strains which are essential for protein medicine by means of the bacterial conjugation and plasmid mobilization technique during space flight.

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Space Applications
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Earth Applications
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Operational Requirements
Thermal insulating container Biokont-T, Recomb-K equipment, Thermostatically controlled container 'Akvarius', Cryogem-03 refrigerator.

Operational Protocols
Study the conjugations of different proteins in the microgravity environment.

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Results/More Information

As follows from the experimental results, it is planned to select optimal conditions for genetic material transfer during bacterial conjugation and protoplast fusion under orbital flight conditions with a maximum output of new recombinant producing strains, which are essential for protein medicine. The developed procedure will be used to create new producing strains of biologically active substances intended for manufacturing medicines.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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image Thermal insulating container 'Biokont-T', Recomb-K equipment, thermostatically controlled container 'Akvarius'.
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