Determination of Intracellular and Extracellular Fluid Volume in Humans in Space Flight (Sprut-MBI (Octopus-MBI)) - 10.21.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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The following content was provided by V B. Noskov, and is maintained in a database by the ISS Program Science Office.

Experiment Details


Principal Investigator(s)

  • V B. Noskov, Institute for Biomedical Problems, Moscow, Russia

  • Co-Investigator(s)/Collaborator(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    June 2002 - April 2006

    Expeditions Assigned

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Investigation of a state of human liquid media, assessment of adaptation mechanisms and prevention of unfavorable impact of zero-gravity on the hydration status and post-flight orthostatic tolerance.

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    Space Applications
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    Earth Applications
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    Operational Requirements
    Sprut-K Kit to determine different human liquid volumes by measuring the impedance of the body and its segments, Body mass meter with a range from 50 kg to 100 kg with an accuracy of 0.25 kg, Hematokrit microcentrifuge to separate plasma from erythrocytes, laptop and power supply unit.

    Operational Protocols
    Determination of volumes of intracellular and intercellular liquid, body's total liquid, circulating blood and relation between cellular and liquid blood component.

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    Results/More Information
    The dynamics of a hydration status of a cosmonaut will be recorded, including analysis of homosapien's separate liquid regions in space flight conditions.

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    Results Publications

      Noskov VB, Nichiporuk IA, Grigoriev AI.  Dynamics of the Body Liquids and Composition in Long-duration Space Flight (Bioimpedance Analysis). Human Physiology. 2011; 37: 821-825. DOI: 10.1134/S0362119711070231.

      Noskov VB, Nichiporuk IA.  Changes in the volume of the fluid spaces in the body of a cosmonaut during long-term spaceflight. Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. 2004; 90(8): 76.

      Noskov VB, Nikolayev DV, Tuykin SA, Kozharinov VI, Grachev VA.  Portable impedancementer for evaluating the body's fluid spaces during spaceflight. Meditsinskaia Tekhnika (Biomedical Engineering). 2007(2): 45-47.

      Noskov VB, Nikolaev DV, Tuikin SA, Kozharinov VI, Grachev VA.  A Portable Impedance Meter for Monitoring Liquid Compartments of the Human Body Under Space Flight Conditions. Meditsinskaia Tekhnika (Biomedical Engineering). 2007; 41(2): 94-96. DOI: 10.1007/s10527-007-0020-7.

      Noskov VB, Nichiporuk IA, Grigoriev AI.  Changes in fluid media and body composition during long-term spaceflight (bioimpedance analysis). Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2007; 41(3): 3-7.

      Noskov VB, Kotov AN.  Impedancemetric research of hydration status and body composition during antiorthostatic . Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2005; 39(4): 41-45.

      Noskov VB, Nichiporuk IA, Morukov BV, Malenchenko YI.  Study of the state of human bodily fluids during long-term spaceflight. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2005; 39(1): 27-31.

      Noskov VB, Kotov AN, Morukov BV, Nichiporuk IA, Shargin YG.  Bioimpedance Analysis of Fluids and Body Composition Under the Conditions of Short-term Space Flight or Hypokinesia. Human Physiology. 2006; 32(5): 622-625. DOI: 10.1134/S0362119706050197. [Also: V.B. Noskov, A.N. Kotov, B.V. Morukov, I.A. Nichiporuk, Yu.G. Shargin, "Bioimpedance Analysis of Fluids and Body Composition During Sort-Term Spaceflights and Hypokinesia," Fiziologiya Cheloveka, 2006, Vol. 32, No. 5, pp. 136–139.]

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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