Cultivation in Weightless of E.coli- Producer of the Caf1 Protein (Astrovaktsina) - 08.12.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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The following content was provided by G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
G. Y. Scherbakov, M.D., Biopreparat, Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration 1
October 2007 - April 2008; April 2009 - September 2010

Expeditions Assigned
16,19/20,21/22,23/24

Previous ISS Missions
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Experiment Description

Research Overview
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Description
The study of effects of space flight environments on the process of cultivating in zero gravity an E. Coli producer of the Caf1 Yersenia pestis antigen protein. Obtaining data on the effects of zero gravity on the biosynthesis, secretion and biological properties of the E. Coli producer of genetically engineered antigen protein Caf1.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements
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Operational Protocols
Returned to Earth are Bioekologia cases and photographic materials taken during the experiment

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Results/More Information

The obtained data will be used for obtaining high-purity Caf1 proteins under ground conditions.

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Results Publications

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Ground Based Results Publications

    Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS.  The Structure of Yersinia pestis V-Antigen, an Essential Virulence Factor and Mediator of Immunity against Plague. Structure. 2004; 12: 301-306. DOI: 10.1016/j.str.2004.01.010.

    Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Motin VL, Smirnov GB, Evstigneev VI, Karkischenko NN, Uversky VN, Brubaker RR.  A study of the interaction of yersinia pestis virulence factors with 1L-1R/TLR recognition system. Totowa, NJ: National Institute of Allergy and  Infections Diseases, NIH; 2008.

    Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Khodyakova AV, Evstigneev VI, Uversky VN, Motin VL, Smirnov GB, Brubaker RR.  Attachment of LcrV from Yersinia pestis at dual binding sites to human TLR-2 and human IFN-gamma receptor. Journal of Proteome Research. 2007 June; 6(6): 2222-2231. DOI: 10.1021/pr070036r.

    Mueller CA, Broz P, Mueller SA, Ringler P, Erne-Brand F, Sorg I, Kuhn M, Engel A, Cornelius G.  The V-Antigen of Yersinia Forms a Distinct Structure at the Tip of Injectisome Needles. Science. 2005 October 28; 310: 674-676.

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery