Cultivation in Weightless of E.coli- Producer of the Caf1 Protein (Astrovaktsina) - 07.15.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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The following content was provided by G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.

Experiment Details

OpNom

Principal Investigator(s)

  • G. Y. Scherbakov, M.D., Biopreparat, Russia

  • Co-Investigator(s)/Collaborator(s)
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    Developer(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    October 2007 - September 2010

    Expeditions Assigned
    16,19/20,21/22,23/24

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Description
    The study of effects of space flight environments on the process of cultivating in zero gravity an E. Coli producer of the Caf1 Yersenia pestis antigen protein. Obtaining data on the effects of zero gravity on the biosynthesis, secretion and biological properties of the E. Coli producer of genetically engineered antigen protein Caf1.

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    Applications

    Space Applications
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    Earth Applications
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    Operations

    Operational Requirements
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    Operational Protocols
    Returned to Earth are Bioekologia cases and photographic materials taken during the experiment

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    Results/More Information
    The obtained data will be used for obtaining high-purity Caf1 proteins under ground conditions.

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    Results Publications

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

      Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Motin VL, Smirnov GB, Evstigneev VI, Karkischenko NN, Uversky VN, Brubaker RR.  A study of the interaction of yersinia pestis virulence factors with 1L-1R/TLR recognition system. Totowa, NJ: National Institute of Allergy and  Infections Diseases, NIH; 2008.

      Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Khodyakova AV, Evstigneev VI, Uversky VN, Motin VL, Smirnov GB, Brubaker RR.  Attachment of LcrV from Yersinia pestis at dual binding sites to human TLR-2 and human IFN-gamma receptor. Journal of Proteome Research. 2007 June; 6(6): 2222-2231. DOI: 10.1021/pr070036r.

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    Related Websites
    Coordinating Scientific and Technical Council of the Russian Space Agency [Russian]
    Energia - Science Research on the ISS Russian Segment

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    Imagery