Soluble Protein Crystallization: Obtaining Crystals of Soluble Proteins FcgIII and FcgeII with a Perfect Crystal Structure (SPC) - 05.13.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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The following content was provided by S. K. Krikalyov, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
S. K. Krikalyov, Yuri Gagarin Cosmonaut Training Center, Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
December 2001 - June 2002

Expeditions Assigned
4

Previous ISS Missions
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Experiment Description

Research Overview
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Description
Obtaining crystals of soluble proteins FcgIII and FcgeII with a highly perfect crystal structure.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements
CPCF-2 module for accommodating 8 experimental reactors, where the processes of protein preparation growth are implemented, thermal insulation container for passive thermostatting CPCF-2 during delivery and return to Earth, activation mechanism for activating/deactivating crystallization processes in experimental reactors placed inside a sealed CPCF-2 module.

Operational Protocols
Obtaining high-quality protein monocrystals that are needed for ground X-ray structure analysis with high resolution.

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Results/More Information

The result of the space experiment is a CPCF-2 module with crystals grown in zero gravity. X-ray structure analysis of protein crystals obtained in space flight will be used in developing in developing a new generation of drugs.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image CPCF-2 module with thermal insulators.
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