Soluble Protein Crystallization: Obtaining Crystals of Soluble Proteins FcgIII and FcgeII with a Perfect Crystal Structure (SPC) - 07.15.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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The following content was provided by S. K. Krikalyov, and is maintained in a database by the ISS Program Science Office.

Experiment Details

OpNom

Principal Investigator(s)

  • S. K. Krikalyov, Yuri Gagarin Cosmonaut Training Center, Russia

  • Co-Investigator(s)/Collaborator(s)
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    Developer(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    December 2001 - June 2002

    Expeditions Assigned
    4

    Previous ISS Missions
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    Experiment Description

    Research Overview
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    Description
    Obtaining crystals of soluble proteins FcgIII and FcgeII with a highly perfect crystal structure.

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    Applications

    Space Applications
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    Earth Applications
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    Operations

    Operational Requirements
    CPCF-2 module for accommodating 8 experimental reactors, where the processes of protein preparation growth are implemented, thermal insulation container for passive thermostatting CPCF-2 during delivery and return to Earth, activation mechanism for activating/deactivating crystallization processes in experimental reactors placed inside a sealed CPCF-2 module.

    Operational Protocols
    Obtaining high-quality protein monocrystals that are needed for ground X-ray structure analysis with high resolution.

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    Results/More Information
    The result of the space experiment is a CPCF-2 module with crystals grown in zero gravity. X-ray structure analysis of protein crystals obtained in space flight will be used in developing in developing a new generation of drugs.

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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    Imagery

    image CPCF-2 module with thermal insulators.
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