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Protein Crystallization in Space: Characterization of the Effect of Microgravity on the Crystal Growth Behavior of Lipases (PCS)
04.26.13

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Overview | Description | Applications | Operations | Results | Publications | Imagery

Experiment Overview

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Brief Summary

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Principal Investigator(s)

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Co-Investigator(s)/Collaborator(s)

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Developer(s)
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Sponsoring Space Agency

Russian Federal Space Agency (Roscosmos)

Sponsoring Organization

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Research Benefits

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ISS Expedition Duration

October 2007 - April 2008

Expeditions Assigned

16

Previous ISS Missions

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Experiment Description

Research Overview

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Description

Characterize the effect of microgravity on the crystal growth behaviour of lipases. Compare the 3D crystal structures of protein crystals obtained on the earth and in space.

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Applications

Space Applications

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Earth Applications

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Operations

Operational Requirements

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Operational Protocols

Grow protein crystals under microgravity.

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Results/More Information

Protein crystals grown under microgravity and photo information recorded on a flash card.

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Results Publications

    Weitz DA, Bailey A, Manley S, Prasad V, Christianson RJ, Sankaran S, Doherty MP, Jankovsky AL, Lorik T, Shiley WL, Bowen JP, Kurta CE, Eggers JC, Gasser U, Segre PN, Cipelletti L, Schofield AB, Pusey PN.  Results From the Physics of Colloids Experiment on ISS. NASA Technical Publication; 2002.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
  • Energia - Science Research on the ISS Russian Segment
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    Imagery

    image The high-density protein crystal growth apparatus (HDPCG) is designed to grow high-density protein crystals. Each HDPCG apparatus contains 6 cells consisting of two chambers containing protein solution and precipitating agent. Two thermostable proteins F16L Lipase and T1 Lipase are used as biological objects. Each of HDPCG apparatus has its own activation/deactivation Handle.
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    Information provided by the investigation team to the ISS Program Scientist's Office.
    If updates are needed to the summary please contact JSC-ISS-Program-Science-Group. For other general questions regarding space station research and technology, please feel free to call our help line at 281-244-6187 or e-mail at JSC-ISS-Research-Helpline.