Biochemical Status of Humans in Long Duration Space Flight (Biotest) - 02.25.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Results for Everyone
To better understand how humans adapt to microgravity, researchers measured hormonal, metabolic, and biochemical indicators on the ground and the final stages of long-term spaceflight. They found no changes in some types of hormones, such as those secreted by the adrenal cortex, which controls stress response. They did find changes in hormones that reflect an individual’s metabolism and activity, such as thyroid hormones. Some of the indicators varied depending on flight duration and crew member age. The data will be used to assess the physical state of crew members on long-duration space flights and help develop and improve diagnostic tools and preventive measures.

The following content was provided by V B. Noskov, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)

  • V B. Noskov, Institute for Biomedical Problems, Moscow, Russia

  • Co-Investigator(s)/Collaborator(s)
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    Developer(s)
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    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
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    Research Benefits
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    ISS Expedition Duration
    August 2001 - April 2005

    Expeditions Assigned
    3,4,5,6,7,8,9,10

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview
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    Description
    Systematic and integrated biochemical examination of the human organism state in zero-gravity conditions to study metabolism adaptation to long-duration space flight conditions.

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    Applications

    Space Applications
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    Earth Applications
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    Operations

    Operational Requirements
    KV-03 container, Set of Plasma-03 consumables, Reflotron-4 pouch, Reflotron-4 set of accessories, Plasma-03 centrifuge, Plasma-03 set of accessories, Minicentrifuge M1100.

    Operational Protocols
    Taking blood samples for a study of biochemical regulation of body homeostasis during adaptation to weightless environment; a study of the role of hormonal mechanisms in the variations in the water-salt, lipid, and protein exchange; and for the selection of informative biochemical indicators to evaluate cosmonaut's health.

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    Results/More Information

    The received information on the metabolism state makes possible assessment of the cosmonauts' physical state throughout long-duration space flights and will be used as the basis for development and improvement of diagnostic and prophylaxis tools.

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    Results Publications

      Smith SM, Westney ME, O'Brian KO, Morukov BV, Larina IM, Abrams SA, Davis-Street DE, Oganov VV.  Bone indicators, metabolism, and calcium kinetics during long-term flights on the Mir orbital station. Gravitatsionnaya Fiziologiya. 2005; 20(2): 208-218.

      Grigoriev AI, Larina IM, Noskov VB.  Effect of spaceflight on the status and regulation of water/electrolyte metabolism. I.M. Sechenov Russian Journal of Physiology. 2006; 92(1).

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    Energia - Science Research on the ISS Russian Segment

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    Imagery

    image Reflectron 4. Image courtesy of FSA.
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    image Plasma 03 centrifuge. Image courtesy of FSA.
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