Biochemical Status of Humans in Long Duration Space Flight (Biotest) - 05.13.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Information Pending
Science Results for Everyone
To better understand how humans adapt to microgravity, researchers measured hormonal, metabolic, and biochemical indicators on the ground and the final stages of long-term spaceflight. They found no changes in some types of hormones, such as those secreted by the adrenal cortex, which controls stress response. They did find changes in hormones that reflect an individual’s metabolism and activity, such as thyroid hormones. Some of the indicators varied depending on flight duration and crew member age. The data will be used to assess the physical state of crew members on long-duration space flights and help develop and improve diagnostic tools and preventive measures.

The following content was provided by V B. Noskov, and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
V B. Noskov, Institute for Biomedical Problems, Moscow, Russia

Co-Investigator(s)/Collaborator(s)
Information Pending

Developer(s)
Information Pending

Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
August 2001 - April 2005

Expeditions Assigned
3,4,5,6,7,8,9,10

Previous ISS Missions
Information Pending

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Experiment Description

Research Overview
Information Pending

Description
Systematic and integrated biochemical examination of the human organism state in zero-gravity conditions to study metabolism adaptation to long-duration space flight conditions.

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Applications

Space Applications
Information Pending

Earth Applications
Information Pending

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Operations

Operational Requirements
KV-03 container, Set of Plasma-03 consumables, Reflotron-4 pouch, Reflotron-4 set of accessories, Plasma-03 centrifuge, Plasma-03 set of accessories, Minicentrifuge M1100.

Operational Protocols
Taking blood samples for a study of biochemical regulation of body homeostasis during adaptation to weightless environment; a study of the role of hormonal mechanisms in the variations in the water-salt, lipid, and protein exchange; and for the selection of informative biochemical indicators to evaluate cosmonaut's health.

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Results/More Information

The received information on the metabolism state makes possible assessment of the cosmonauts' physical state throughout long-duration space flights and will be used as the basis for development and improvement of diagnostic and prophylaxis tools.

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Results Publications

    Smith SM, Westney ME, O'Brian KO, Morukov BV, Larina IM, Abrams SA, Davis-Street DE, Oganov VV.  Bone indicators, metabolism, and calcium kinetics during long-term flights on the Mir orbital station. Gravitatsionnaya Fiziologiya. 2005; 20(2): 208-218.

    Grigoriev AI, Larina IM, Noskov VB.  Effect of spaceflight on the status and regulation of water/electrolyte metabolism. I.M. Sechenov Russian Journal of Physiology. 2006; 92(1).

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Reflectron 4. Image courtesy of FSA.
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image Plasma 03 centrifuge. Image courtesy of FSA.
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