T-Cell Growth System (T-CGS) - 07.15.14

Summary | Overview | Operations | Results | Publications | Imagery
ISS Science for Everyone

Science Objectives for Everyone T-Cell Growth System (T-CGS) can propagate live mouse, rat, and human thymus tissue to investigate the problem of reduced white blood cell counts in long-duration crewmembers.

Science Results for Everyone
Information Pending



The following content was provided by Carole Hammond, and is maintained in a database by the ISS Program Science Office.

Facility Details

OpNom:

Facility Manager(s)

  • Carole Hammond, Paragon Space Development Corporation, Tucson, AZ, United States

  • Facility Representative(s)
    Information Pending
    Developer(s)

    Paragon Space Development Corporation, Tucson, AZ, United States

    Sponsoring Space Agency
    National Aeronautics and Space Administration (NASA)

    Sponsoring Organization
    Human Exploration and Operations Mission Directorate (HEOMD)

    ISS Expedition Duration


    Expeditions Assigned
    Information Pending

    Previous ISS Missions
    T-CGS is unique hardware that is being newly utilized for microgravity research.

    Availability
    Information Pending

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    Facility Description

    Facility Overview

    • The T-Cell Growth System (T-CGS) is designed to maintain cell cultures in a 2-dimensional petri dish by providing nutrients in a controlled fashion and a growth substrate in microgravity.


    • The growth nutrients are transferred via a wick to a growth substrate using a novel silica tile material. The units are designed to be maintained at 37 degrees C and to contain a 5% carbon dioxide/air combination environment through the use of non-permeable seals and material.
    T-Cell Growth System (T-CGS) can propagate live mouse, rat, and human thymus (T-Cell) tissue to investigate the problem of reduced white blood cell count in long-duration crewmembers. The T-CGS consists of a quartz dish system, seal, quartz lid, wicking silica tile, Millipore paper (as the substrate) and growth medium containment chamber. The system is designed to be loaded in a laboratory environment with precursor T-Cells, from mice, rats or humans. The T-Cells then propagate and mature into other precursor T-cells. The quartz is utilized to allow for adequate thermal mass for thermal control during shipping while also providing a robust, non-permeable system (unlike laboratory Petri dishes) to contain the carbon dioxide rich environment nominally present in incubators.

    The T-CGS is designed to allow for research into the physiological effects of microgravity on the development of cells, especially for the development of precursor immune cells.The T-CGS is 7.6 cm x 7.6 cm x 3.8 cm. The assembly weighs 15 kg and requires no power. The crewmember is responsible for placing the T-CGS inside an incubator following arrival at ISS for activation. Once competed the T-CGS will be returned to Earth.

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    Operations

    Facility Operations

    • T-CGS is launched and transferred to the ISS for initiation. T-CGS is placed inside an incubator for a set time designated by the investigator.


    • Following completion of the experiment the T-CGS is removed from the incubator and returned to Earth.

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    Results/More Information
    Information Pending

    Results Publications

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites

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    Imagery

    image T-Cell Growth System for use on the Shuttle and ISS. The sealed Petri Dish system propagates live mouse, rat, and human thymus tissue to investigate the problem of reduced white blood cell count in long-duration astronauts. Image courtesy of Paragon Space Development Corporation.
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