Production of Hight Quality Crystals of Interleukin -1Alpha, -1Beta and Receptor of Antagonist of Interleukin-1 (InterleIkin-K) - 05.13.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

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Science Results for Everyone
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The following content was provided by E. N. Sventitski, G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details

OpNom:

Principal Investigator(s)
E. N. Sventitski, Biopreparat, Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia

Co-Investigator(s)/Collaborator(s)
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Developer(s)
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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
April 2003 - October 2008

Expeditions Assigned
7,8,9,10,13,16,17

Previous ISS Missions
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Experiment Description

Research Overview
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Description
Production of crystals of interleukins-1 alpha, -1 beta and receptor antagonist of interleukin-1 under space flight conditions, which are suitable for x-ray crystal analysis.

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements
Luch-2 equipment accommodating multipurpose crystallization cassettes, Thermal insulating container Biokont-T for transportation of the Luch-2 equipment, Temperature-stable container "AQUA 01".

Operational Protocols
Development of the procedure for interleukin crystallization under orbital flight conditions. Production of interleukin crystals that are larger in size and the structure of which is more ordered as compared with the crystals grown on the ground.

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Results/More Information

Peptides carrying the main protein properties with no adverse effects produced can be synthesized.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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Imagery

image Luch-2 equipment accommodating multipurpose crystallization cassettes.
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image Thermal insulating container Biokont-T for transportation of the Luch-2 equipment.
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image Temperature-stable container "AQUA 01".
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