Production of Hight Quality Crystals of Interleukin -1Alpha, -1Beta and Receptor of Antagonist of Interleukin-1 (InterleIkin-K) - 12.03.13

Overview | Description | Applications | Operations | Results | Publications | Imagery

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This content was provided by E. N. Sventitski, G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.

Experiment Details

OpNom:

Principal Investigator(s)

  • E. N. Sventitski, Biopreparat, Russia
  • G. Y. Scherbakov, M.D., Biopreparat, Russia
  • Co-Investigator(s)/Collaborator(s)

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    Developer(s)
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    Sponsoring Space Agency

    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization

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    Research Benefits

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    ISS Expedition Duration:

    April 2003 - October 2008

    Expeditions Assigned

    7,8,9,10,13,16,17

    Previous ISS Missions

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    Experiment Description

    Research Overview

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    Description

    Production of crystals of interleukins-1 alpha, -1 beta and receptor antagonist of interleukin-1 under space flight conditions, which are suitable for x-ray crystal analysis.

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    Applications

    Space Applications

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    Earth Applications

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    Operations

    Operational Requirements

    Luch-2 equipment accommodating multipurpose crystallization cassettes, Thermal insulating container Biokont-T for transportation of the Luch-2 equipment, Temperature-stable container "AQUA 01".

    Operational Protocols

    Development of the procedure for interleukin crystallization under orbital flight conditions. Production of interleukin crystals that are larger in size and the structure of which is more ordered as compared with the crystals grown on the ground.

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    Results/More Information

    Peptides carrying the main protein properties with no adverse effects produced can be synthesized.

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    Related Websites
  • Coordinating Scientific and Technical Council of the Russian Space Agency [Russian]
  • Energia - Science Research on the ISS Russian Segment
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    Imagery

    image Luch-2 equipment accommodating multipurpose crystallization cassettes.
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    image Thermal insulating container Biokont-T for transportation of the Luch-2 equipment.
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    image Temperature-stable container "AQUA 01".
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