Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease with New Portable Equipment (Card) - 07.29.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
ISS Science for Everyone

Science Objectives for Everyone
The Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease with New Portable Equipment (Card) experiment studies blood pressure decreases in the human body exposed to microgravity on board the ISS.

Science Results for Everyone

People with high blood pressure should head for orbit. The Card investigation monitored eight male astronauts and found a decrease in their 24-hour awake blood pressure that was equal to a low dose of anti-hypertensive medication. Researchers also found a 30 percent increase in cardiac output and a 30 percent decrease in resistance to blood flow through peripheral blood vessels.  It seems three to six months of spaceflight expands the blood vessels and lowers blood pressure which is good for hypertensive space travelers.  Researchers also observed unchanged levels of activity of sympathetic motor nerves, which is surprising in light of the other findings and requires further investigation.



This content was provided by Peter Norsk, M.D., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.

Experiment Details

OpNom

Principal Investigator(s)

  • Peter Norsk, M.D., University of Copenhagen, Copenhagen, Denmark

  • Co-Investigator(s)/Collaborator(s)
  • Niels Juel Christensen, University of Copenhagen, Copenhagen, Denmark
  • Anders Gabrielsen, M.D., Danish Aerospace Medical Center of Research National University Hospital (Rigshospitalet), Copenhagen, Denmark
  • Mogens Tango, M.D., Karolinska Hospital, Stockholm, Sweden
  • Morten Damgaard, M.D., Bispebjerg University Hospital, Copenhagen, Denmark
  • Niels Gadsboll, M.D., Bispebjerg University Hospital, Copenhagen, Denmark
  • Martina A. Heer, Ph.D., • Profil Institut für Stoffwechselforschung , Neuss, Germany
  • B. Pump, Denmark
  • Jens Nielsen, Ph.D., Technical University of Denmark, Kongens Lyngby, Denmark
  • C. Drummer, Germany
  • M. Kentsch, Germany

  • Developer(s)
    Danish Aerospace Medical Centre of Research, Copenhagen, , Denmark

    Sponsoring Space Agency
    European Space Agency (ESA)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    September 2006 - September 2012

    Expeditions Assigned
    14,19/20,21/22,25/26,27/28,29/30,31/32

    Previous ISS Missions
    Card is an ongoing USOS integrated investigation which began on ISS Expedition 19/20.

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    Experiment Description

    Research Overview

    • Blood pressure will be measured automatically using a portable device at various intervals.


    • Cardiac output will be measured using the foreign gas rebreathing technique.


    • Urine will be collected to measure renal sodium output.


    • Blood will be collected to test for the determination of chronic sympathetic nervous activity.

    Description
    The Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease with New Portable Equipment (Card) experiment studies blood pressure decreases when the human body is exposed to microgravity. In order to increase the blood pressure to the level it was on Earth, salt is added to the crewmembers' diet. To monitor this, blood pressure readings and urine samples are performed at different intervals during the mission.

    In microgravity, the cardiovascular system relaxes causing a drop in the blood volume and pressure. This also causes the fluid and sodium retaining systems to be activated. One theory of this occurrence is that the body's of sodium is decreased. This investigation will examine whether blood pressure and volume can be restored to the same levels that were measured during groundbased measurements by adding additional salt to the astronauts' food.

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    Applications

    Space Applications
    Information Pending

    Earth Applications
    Information Pending

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    Operations

    Operational Requirements
    Card requires the collection of urine and blood samples. Blood pressure will be measured by a portable equipment device called an oscillometry. The foreign gas rebreathing technique will be used to measure cardiac output.

    Operational Protocols
    Information Pending

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    Results/More Information
    Information Pending

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    Results Publications

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

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    Related Websites
    The information on this page is provided courtesy of the ESA Erasmus Experiment Archive.
    The information provided is courtesy of the ESA Astrolab Mission web page.
    Astrolab Newsletter

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    Imagery

    image NASA Image: ISS019E018475 - Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 19 flight engineer, prepares to blow into the Pulmonary Function Module/Photoacoustic Analyzer Module (PFM/PAM) rebreathing unit for the Pulmonary Function System (PFS) to begin Day 1 of the ESA cardiological experiment CARD (Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease. The hardware is located on the Human Research Facility Rack 2 (HRF-2) in the Columbus module.
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    image NASA Image: ISS020E046971 - View of Astronaut Michael Barratt,Expedition 19/20 flight engineer,working at the ESA cardiological experiment CARD (Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease) in the U.S. Laboratory.
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