Investigation of the Effects of Space Flight Factors on the Technological and Biomedical Characteristics of Bifidobacterium (Bif) - 01.09.14

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone To reveal features of metabolism and morphology of different phenotypes of one strain of bifidobacteria caused by microgravity conditions to produce probiotics with the increased biomedical factors and increase the production efficiency.

Science Results for Everyone Information Pending



This content was provided by G. Y. Scherbakov, M.D., I. V. Nyn, and is maintained in a database by the ISS Program Science Office.

Experiment Details

OpNom:

Principal Investigator(s)

  • G. Y. Scherbakov, M.D., Biopreparat, Russia
  • I. V. Nyn, Biopreparat, Russia
  • Co-Investigator(s)/Collaborator(s)
    Information Pending

    Developer(s)
    Information Pending

    Sponsoring Space Agency
    Russian Federal Space Agency (Roscosmos)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration:
    October 2009 - September 2013

    Expeditions Assigned
    21/22,23/24,27/28,29/30,33/34,35/36

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview
    Information Pending

    Description
    Provision of the clone collection of Bifidobacterium bifidum1 strain with heritable deviations of morphophysiological characteristics. Genetic analysis in mutant clones. Identification of viability, antagonistic activity, acid formation activity, adhesion activity, resistance to antibiotics, air oxygen, acid medium and determination of the cultivation parameters in ground conditions. Selection of possible candidates for production strains of bifidobacteria having the increased biotechnological and biomedical characteristics as compared with the wild and other production strains. Presentation of description of experiments for the characteristics analysis of A. bifidum1 strain and its changed forms in microgravity conditions and data processing.

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    Applications

    Space Applications
    Information Pending

    Earth Applications
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    Operations

    Operational Requirements
    BIF will use Case Bioecologia with ampullas sealed observing sterility containing 1.5 ml of lyophilically dried A. bifidum 1 strain in Blaurock medium with addition of protective media (sugar-gelatin and skim milk and also options with unithiol), hermetically closed test tubes containing 4 ml of liquid culture A. bifidum 1 in Blaurock medium in the concentration no less than 107 kl/ml. Thermostat Cryogem-0CI.

    Operational Protocols
    Information Pending

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    Results/More Information
    Use of modern methods of comparative study of genetic, morphological, cytologic, biochemical and cultural characteristics of options obtained in the experiment will allow to get the maximum full characteristic of genetic and metabolic potential of Bifidobacterium bifidum 1. As a result the following is expected: a significant renewal of the spectrum of possible candidates for production strains of bifidobacteria having the increased biotechnological and biomedical characteristics as compared with a wild strain.

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    Related Websites

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    Imagery