Investigation of the Effects of Space Flight Factors on the Technological and Biomedical Characteristics of Bifidobacterium (Bif) - 08.05.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
To reveal features of metabolism and morphology of different phenotypes of one strain of bifidobacteria caused by microgravity conditions to produce probiotics with the increased biomedical factors and increase the production efficiency.
Science Results for Everyone
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The following content was provided by I. V. Nyn, G. Y. Scherbakov, M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)
I. V. Nyn, Biopreparat, Russia
G. Y. Scherbakov, M.D., Biopreparat, Russia

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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
October 2009 - September 2013

Expeditions Assigned

Previous ISS Missions
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Experiment Description

Research Overview
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Provision of the clone collection of Bifidobacterium bifidum1 strain with heritable deviations of morphophysiological characteristics. Genetic analysis in mutant clones. Identification of viability, antagonistic activity, acid formation activity, adhesion activity, resistance to antibiotics, air oxygen, acid medium and determination of the cultivation parameters in ground conditions. Selection of possible candidates for production strains of bifidobacteria having the increased biotechnological and biomedical characteristics as compared with the wild and other production strains. Presentation of description of experiments for the characteristics analysis of A. bifidum1 strain and its changed forms in microgravity conditions and data processing.

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Space Applications
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Earth Applications
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Operational Requirements
BIF will use Case Bioecologia with ampullas sealed observing sterility containing 1.5 ml of lyophilically dried A. bifidum 1 strain in Blaurock medium with addition of protective media (sugar-gelatin and skim milk and also options with unithiol), hermetically closed test tubes containing 4 ml of liquid culture A. bifidum 1 in Blaurock medium in the concentration no less than 107 kl/ml. Thermostat Cryogem-0CI.

Operational Protocols
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Results/More Information

Use of modern methods of comparative study of genetic, morphological, cytologic, biochemical and cultural characteristics of options obtained in the experiment will allow to get the maximum full characteristic of genetic and metabolic potential of Bifidobacterium bifidum 1. As a result the following is expected: a significant renewal of the spectrum of possible candidates for production strains of bifidobacteria having the increased biotechnological and biomedical characteristics as compared with a wild strain.

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Related Websites
Energia - Science Research on the ISS Russian Segment

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