Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity-2 (ROALD-2) - 09.17.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
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Science Objectives for Everyone
Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity (ROALD2) investigates the function of endocannabinoids, substances produced within the body to activate cell membrane receptors, in the regulation of the immune processes and cell cycle under microgravity conditions.

Science Results for Everyone
Information Pending



The following content was provided by Natalia Battista, Ph., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.

Experiment Details

OpNom

Principal Investigator(s)

  • Natalia Battista, Ph., University of Teramo, Teramo, Italy

  • Co-Investigator(s)/Collaborator(s)
  • Mauro Maccarrone, University of Teramo, Teramo, Italy
  • Cinzia Rapino, University of Teramo, Teramo, Italy
  • M. Di Tommaso, University of Teramo, Teramo, Italy
  • Monica Bari, University of Rome Tor Vergata, Rome, Italy
  • Valeria Gasperi, University of Rome, Rome, Italy
  • Alessandro Finazzi-Agrò, University of Rome, Rome, Italy

  • Developer(s)
    Information Pending
    Sponsoring Space Agency
    European Space Agency (ESA)

    Sponsoring Organization
    Information Pending

    Research Benefits
    Information Pending

    ISS Expedition Duration
    September 2011 - May 2012

    Expeditions Assigned
    29/30

    Previous ISS Missions
    ROALD2 expands on the objectives of the ROALD experiment flown on ISS in 2008 (BIO-4 mission), using similar experiment protocol.

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    Experiment Description

    Research Overview

    • Anandamide (AEA) is the main representative of a family of polyunsaturated fatty acid amides and esters, called endocannabinoids.


    • This project aims at investigating gene expression of the proteins involved in the metabolic control of AEA tone, in order to determine the role of this lipid in the regulation of immune processes and in the cell cycle under microgravity conditions.


    • In fact, AEA is a signal for the cells to make a choice between life and death and it might be a contributor responsible for the immune deficit observed in space.

    Description
    Information Pending

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    Applications

    Space Applications
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    Earth Applications
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    Operations

    Operational Requirements
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    Operational Protocols
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    Results/More Information

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    Results Publications

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    Ground Based Results Publications

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    ISS Patents

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    Related Publications

      Battista N, Meloni MA, Bari M, Mastrangelo N, Galleri G, Rapino C, Dainese E, Finazzi-Agro A, Pippia P, Maccarrone M.  5-Lipoxygenase-dependent apoptosis of human lyphocytes in the International Space Station: data from the ROALD experiment. Federation of American Societies for Experimental Biology Journal. 2012; 26(5): 1791-1798. DOI: 10.1096/fj.11-199406. PMID: 22253478.

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    Related Websites

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    Imagery