Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity-2 (ROALD-2) - 05.13.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Role of the Endocannabinoid System in human Lymphocytes Exposed to Microgravity (ROALD2) investigates the function of endocannabinoids, substances produced within the body to activate cell membrane receptors, in the regulation of the immune processes and cell cycle under microgravity conditions.
Science Results for Everyone
Information Pending

The following content was provided by Natalia Battista, Ph., and is maintained in a database by the ISS Program Science Office.
Information provided courtesy of the Erasmus Experiment Archive.
Experiment Details

OpNom:

Principal Investigator(s)
Natalia Battista, Ph., University of Teramo, Teramo, Italy

Co-Investigator(s)/Collaborator(s)
Mauro Maccarrone, University of Teramo, Teramo, Italy
Cinzia Rapino, University of Teramo, Teramo, Italy
M. Di Tommaso, University of Teramo, Teramo, Italy
Valeria Gasperi, University of Rome, Rome, Italy
Monica Bari, University of Rome Tor Vergata, Rome, Italy
Alessandro Finazzi-Agrò, University of Rome, Rome, Italy

Developer(s)
Information Pending

Sponsoring Space Agency
European Space Agency (ESA)

Sponsoring Organization
Information Pending

Research Benefits
Information Pending

ISS Expedition Duration
September 2011 - May 2012

Expeditions Assigned
29/30

Previous ISS Missions
ROALD2 expands on the objectives of the ROALD experiment flown on ISS in 2008 (BIO-4 mission), using similar experiment protocol.

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Experiment Description

Research Overview

  • Anandamide (AEA) is the main representative of a family of polyunsaturated fatty acid amides and esters, called endocannabinoids.


  • This project aims at investigating gene expression of the proteins involved in the metabolic control of AEA tone, in order to determine the role of this lipid in the regulation of immune processes and in the cell cycle under microgravity conditions.


  • In fact, AEA is a signal for the cells to make a choice between life and death and it might be a contributor responsible for the immune deficit observed in space.

Description
Information Pending

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Applications

Space Applications
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Earth Applications
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Operations

Operational Requirements
Information Pending

Operational Protocols
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Results/More Information

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Results Publications

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Ground Based Results Publications

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ISS Patents

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Related Publications

    Battista N, Meloni MA, Bari M, Mastrangelo N, Galleri G, Rapino C, Dainese E, Finazzi-Agro A, Pippia P, Maccarrone M.  5-Lipoxygenase-dependent apoptosis of human lyphocytes in the International Space Station: data from the ROALD experiment. FASEB: Federation of American Societies for Experimental Biology Journal. 2012; 26(5): 1791-1798. DOI: 10.1096/fj.11-199406. PMID: 22253478.

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Related Websites

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Imagery