Rodent Research-2 (NASA #2) (Rodent Research-2 (NASA #2)) - 01.15.14

Overview | Description | Applications | Operations | Results | Publications | Imagery
ISS Science for Everyone

Science Objectives for Everyone

Living in space causes several physical changes to the human body, including microscopic changes in the vascular system. Rodent Research-2 determines which changes occur in the blood-brain barrier during spaceflight, as fluid pressure on the brain increases. Understanding the effects of microgravity on brain vasculature could provide insight into space-related neurological changes, such as impaired vision or reduced cognitive ability.

Science Results for Everyone
Information Pending

This content was provided by Michael J. Pecaut, Ph.D., and is maintained in a database by the ISS Program Science Office.

Experiment Details

OpNom RR2

Principal Investigator(s)

  • Michael J. Pecaut, Ph.D., Loma Linda University, Loma Linda, CA, United States

  • Co-Investigator(s)/Collaborator(s)
  • Stephen Keith Chapes, Ph.D., M.P.H., Kansas State University, Manhattan, KS, United States
  • Daila S. Gridley, Ph.D., Loma Linda University, Loma Linda, CA, United States

  • Developer(s)
    NASA Ames Research Center, Moffett Field, CA, United States

    Sponsoring Space Agency
    National Aeronautics and Space Administration (NASA)

    Sponsoring Organization
    Human Exploration and Operations Mission Directorate (HEOMD)

    Research Benefits
    Information Pending

    ISS Expedition Duration
    September 2014 - March 2015

    Expeditions Assigned

    Previous ISS Missions
    Information Pending

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    Experiment Description

    Research Overview
    Information Pending

    Information Pending

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    Space Applications

    Simulating the microgravity, radiation and launch conditions of spaceflight is difficult to do on Earth. Subjecting rats to the real environment of space will provide crucial information about how mammals respond to those stressors. Specifically, understanding how spaceflight causes physical changes in brain vasculature could help explain reported changes in vision during space missions

    Earth Applications

    Rodent Research-2 will demonstrate how changes in blood pressure can affect blood flow to the brain, and how this could affect vision. Understanding the relationship between blood pressure and brain vasculature could provide insights for neuroscience on Earth, including for patients with brain injuries or neurological disorders.

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    Operational Requirements
    Information Pending

    Operational Protocols
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    Results/More Information
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    Related Websites

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