Dynamics of the Main Factors of Cardiac Function, of Central and Regional Circulation in Rest and During the Influence of Lower Body Negative Pressure (Cardio-ODNT) - 08.05.15

Overview | Description | Applications | Operations | Results | Publications | Imagery

ISS Science for Everyone

Science Objectives for Everyone
Cardio-ODNT (Cardio-Lower Body Negative Pressure) is a medical investigation designed to determine the condition of the cardiovascular system in the lower extremities. Cardio-ODNT uses a pneumatic-vacuum suit to produce a negative pressure to the extremities while physical load is being produced by the cosmonaut.
Science Results for Everyone
These pants are tight for a good reason. Space station crewmembers wore a lower body negative pressure suit to evaluate cardiac activity and circulation in the legs in microgravity. The results clarified microgravity’s effect on blood vessels in the legs and showed which regions of the body are most affected by long-term exposure. Using the suit to apply negative pressure to the legs during flight had positive effects on circulation throughout the body, but particularly in the pulmonary region, which is most affected by microgravity. Results indicated that sessions in the pressure suit will be useful in helping prepare crewmembers for return to Earth.

The following content was provided by Valery V. Bogomolov, Ph.D., M.D., and is maintained in a database by the ISS Program Science Office.
Experiment Details


Principal Investigator(s)
Valery V. Bogomolov, Ph.D., M.D., Institute for Biomedical Problems, Moscow, Russia

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Sponsoring Space Agency
Russian Federal Space Agency (Roscosmos)

Sponsoring Organization
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Research Benefits
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ISS Expedition Duration
October 2004 - October 2008

Expeditions Assigned

Previous ISS Missions
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Experiment Description

Research Overview
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Investigation of dynamics of basic factors of cardiac activity and blood circulation.

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Space Applications
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Earth Applications
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Operational Requirements
Gamma-1M hardware to record electrocardiogram, arterial pressure, rheograms of different vessel areas including rheoencephalograms, Chibis pneumatic-vacuum suit to perform a test physical load when producing a negative pressure (from 10 to 60 mm Hg) to the lower part of the cosmonaut's body.

Operational Protocols
Investigation of responses of big and small circles of blood circulation when negative pressure affects the lower part of the body and the dependence of these responses on the initial status of the cardiovascular system.

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Results/More Information

Prediction of a cosmonauts' cardiovascular system state.

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Results Publications

    Turchaninova VF, Alferova IV, Krivolapov VV, Liamin VR, Beliaev AP.  Dependence of the circulation system functioning on cosmonaut age according to the results of physical loading tests on a veloergometer. Human Physiology. 2013 December 29; 39(7): 707-711. DOI: 10.1134/S0362119713070189. [

    Original Russian Text © V.F. Turchaninova, I.V. Alferova, V.V. Krivolapov, V.R. Liamin, A.P. Beliaev, 2010, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2010, Vol. 44, No. 5, pp. 8–12.]

    Turchaninova VF, Alfyorova IV, Krivolapov VV.  Several aspects of a comparative analysis of hemodynamic reactions to LBNP in crewmembers from various age groups. Aviakosmicheskaia i Ekologicheskaia Meditsina (Aerospace and Environmental Medicine). 2010; 44(1): 20-25.

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Ground Based Results Publications

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ISS Patents

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Related Publications

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Related Websites
Energia - Science Research on the ISS Russian Segment

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image Chibis pneumatic-vacuum suit. Image courtesy of Russian Space Agency (FSA).
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image Gamma-1M hardware. Image courtesy of Russian Space Agency (FSA).
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