| Mission | Primary Payload | Launch | Landing |
| STS-35 | ASTRO-1 | 12/02/1990 | 12/10/1990 |
| STS-38 | Department of Defense (DOD) | 11/15/1990 | 11/20/1990 |
| STS-41 | Ulysses; Shuttle Solar Backscatter Ultraviolet (SSBUV); INTELSAT Solar Array Coupon (ISAC) | 10/06/1990 | 10/10/1990 |
| STS-31 | Hubble Space Telescope (HST) deploy | 04/24/1990 | 04/29/1990 |
| STS-36 | Department of Defense (DOD) | 02/28/1990 | 03/04/1990 |
| STS-32 | Synchronous Communication Satellite IV-F5 (SYNCOM IV-F5); Long Duration Exposure Facility (LDEF) Retrieval | 01/09/1990 | 01/20/1990 |
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