| STS-9 |
Columbia, Nov. 28 - Dec. 8, 1983 was the first Spacelab module flight, Spacelab-1. |
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| STS 51-B |
Challenger, April 29 - May 6, 1985 this flight was considered to be the first operational flight of the Spacelab module. Spacelab-3 covered five basic fields of investigation. Spacelab-3 was flown out of sequence and ahead of Spacelab-2. |
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| STS 51-F |
Challenger, July 29 - Aug. 6, 1985 Spacelab-2 was the primary payload. Instead of a laboratory module, this a featured three-pallet train holding instruments exposed to the space environment. This was the second and final Spacelab verification flight. |
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| STS 61-A |
Challenger, Oct. 30 - Nov. 6, 1985 this flight was a dedicated German Spacelab (Spacelab D-1) mission featuring the Spacelab module. |
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| STS-35 |
Columbia, Dec. 2 - 10, 1990 the first flight of the astronomical observatory, ASTRO-1, a collection of instruments mounted atop the Spacelab Instrument Pointing System and pallets in the orbiter payload bay. |
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| STS-40 |
Columbia, June 5 - 14, 1991 the fifth dedicated Spacelab mission carried the Spacelab Life Sciences-1 (SLS-1), the first Spacelab flight dedicated to a single discipline, the life sciences. |
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| STS-42 |
Discovery, Jan. 22 - 30, 1992 the first flight of the International Microgravity Laboratory-1 (IML-1), featuring a Spacelab module. |
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| STS-45 |
Atlantis, March 24 - April 2, 1992 the first flight of the Atmospheric Laboratory for Applications and Science-1 (ATLAS-1), mounted on non-deployable Spacelab pallets. |
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| STS-50 |
Columbia, June 25 - July 9, 1992 the first flight of the U.S. Microgravity Laboratory-1 (USML-1) in a Spacelab module. |
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| STS-47 |
Endeavour, Sept. 12 - 20, 1992 A Spacelab flight jointly sponsored by the United States and Japan, designated as Spacelab-J (SL-J), featuring a Spacelab module. |
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| STS-52 |
Columbia, Oct. 22 - Nov. 1, 1992 the first flight of the U.S. Microgravity Payload-1 (USMP-1), a complement of three experiments mounted on two connected Spacelab Multipurpose Experiment Support Structures (MPESSs) in the cargo bay of Columbia. |
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| STS-56 |
Discovery, April 8 - 17, 1993 the second flight of the Atmospheric Laboratory for Applications and Science, ATLAS-2, mounted on a Spacelab pallet. |
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| STS-55 |
Columbia, April 26 - May 6, 1993 the second dedicated German Spacelab flight, Spacelab D-2, featuring a Spacelab laboratory module. |
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| STS-58 |
Columbia, Oct. 18 - Nov. 1, 1993 the second dedicated Spacelab Life Sciences mission (SLS-2) using a Spacelab module. |
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| STS-62 |
Columbia, March 4 - 18, 1994 the second flight of the U.S. Microgravity Payload-2 (USMP-2) mounted on two connected Spacelab Multipurpose Experiment Support Structures (MPESSs) in the orbiter payload bay. |
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| STS-65 |
Columbia, July 8 - 23, 1994 the second flight of the International Microgravity Payload (IML-2) with Spacelab module. |
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| STS-66 |
Atlantis, Nov. 3 - 14, 1994 the third flight of the Atmospheric Laboratory for Applications and Science (ATLAS-3) on a Spacelab pallet in the payload bay. |
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| STS-67 |
Endeavour, March 2 - 18, 1995 the second flight of the astronomical observatory (ASTRO-2), mounted on the Spacelab Instrument Pointing System and pallets in the orbiter payload bay. |
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| STS-73 |
Columbia, Oct. 20 - Nov. 5, 1995 the second flight of the U.S. Microgravity Laboratory (USML-2) in the Spacelab module. |
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| STS-75 |
Columbia, Feb. 22 - March 9, 1996 the third flight of the U.S. Microgravity Payload (USMP-3) on the Spacelab pallet. |
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| STS-78 |
Columbia, June 20 - July 7, 1996 the Life and Microgravity Spacelab (LMS) on the longest shuttle flight to date. |
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| STS-83 |
Columbia, April 4 - 8, 1997 the Microgravity Science Laboratory-1. The planned 16-day mission was cut short after a fuel cell malfunction. |
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| STS-94 |
Columbia, July 1 - 17, 1997 the Microgravity Science Laboratory-1 reflight. |
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| STS-90 |
Columbia, April 17 - May 3, 1998 the Neurolab which was the final Spacelab mission. |
