Understanding the interface between the photosphere and corona remains a fundamental challenge in solar and heliospheric science. The Interface Region Imaging Spectrograph (IRIS) mission opens a window of discovery into this crucial region by tracing the flow of energy and plasma through the chromosphere and transition region into the corona using spectrometry and imaging. IRIS is designed to provide significant new information to increase our understanding of energy transport into the corona and solar wind and provide an archetype for all stellar atmospheres. The unique instrument capabilities, coupled with state of the art 3-D modeling, will fill a large gap in our knowledge of this dynamic region of the solar atmosphere. The mission will extend the scientific output of existing heliophysics spacecraft that follow the effects of energy release processes from the sun to Earth.