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Evidence
MDRP
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Risk Hierarchy
MDRP Hierarchy
Element
Risk
Gap
Task
Exploration Medical Capability
Risk of Adverse Health and Performance Effects of Celestial Dust Exposure
Dust-101: We need to determine if there are significant differences in the acute and chronic toxicity of dusts from different exploration targets, and whether existing permissible exposure limits can be applied or if new PELs are needed.
AEH 1: What are the unique properties of lunar dust that affect physiology? (Closed)
Geology, Geochemistry and Lithology Science Support Activities
Study of Lunar Dust and Lunar Simulant Activation, Monitoring, Solution and Cellular Toxicity Properties
AEH 2: What is the toxicity of lunar dust in the respiratory system? (Closed)
Cellular Studies to Support Pulmonary Toxicology Evaluation of Lunar Dust, Dermal Studies of Lunar Dust and Ocular Studies of Lunar Dust
Pulmonary Toxicity Studies of Lunar Dust in Mice and Rats
Study of Lunar Dust and Lunar Simulant Activation, Monitoring, Solution and Cellular Toxicity Properties
Clearance of Particles Depositing in the Human Lung in Low-Gravity
AEH 4: What is the dermal and ocular toxicity of lunar dust? (Closed)
Cellular Studies to Support Pulmonary Toxicology Evaluation of Lunar Dust, Dermal Studies of Lunar Dust and Ocular Studies of Lunar Dust
AEH 5: What are the permissible exposure limits for inhalation of lunar dust? (Closed)
Cellular Studies to Support Pulmonary Toxicology Evaluation of Lunar Dust, Dermal Studies of Lunar Dust and Ocular Studies of Lunar Dust
Geology, Geochemistry and Lithology Science Support Activities
LADTAG Lunar Dust Health Standard
Pulmonary Toxicity Studies of Lunar Dust in Mice and Rats
Study of Lunar Dust and Lunar Simulant Activation, Monitoring, Solution and Cellular Toxicity Properties
Clearance of Particles Depositing in the Human Lung in Low-Gravity
DUST 11: What is the potential for acute toxicity of lunar dust (all relevant endpoints), and acute/chronic cardiovascular toxicity of lunar dust? (Previous title: AEH 11)
Adverse Cardiopulmonary Effects of Exposure to Extraterrestrial Dusts - Implications for Space Travel
AEH Watch Item/NSBRI Research: What are the effects of lunar gravity on permissible exposure limits for inhalation of lunar dust? (Closed)
Aerosol Deposition in the Lung in Fractional Gravity: Risk Mitigation for Lunar and Martian Habitats
Clearance of Particles Depositing in the Human Lung in Low-Gravity
Variability in flow distribution within the lung and its effects on deposition and clearance of inhaled particles in normal and reduced gravity (NSBRI Postdoctoral Fellowship)
DUST 12: We need to determine if technologies are available or need to be developed to evaluate celestial dust toxicity and/or volatile composition in situ.
Risk of Adverse Health Outcomes and Decrements in Performance Due to Medical Conditions that occur in Mission, as well as Long Term Health Outcomes Due to Mission Exposures
Medical-101: We need to characterize the medical conditions that can occur during exploration missions and their relevant associated end states, management options, and the capabilities necessary to manage them (what can happen, how bad could it be, what can we do to improve it?).
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.0
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.x
Risk Quantification Pilot with IMM for HSRB
Medical-201: We need to characterize the resource “costs” associated with each relevant exploration medical capability.
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.0
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.x
Medical-301: We need to prioritize the relevant exploration medical capabilities in order to perform medical system trade space analysis.
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.0
Medical-401: We need to characterize the predicted resource or risk constraints associated with exploration missions in order to determine which capabilities (and associated resources) should be included in an exploration medical system.
Quantify impacts of physician training on medical task performance
Intuitive Ultrasound Catalog for Autonomous Medical Care
ExMC Support of Medical Scenarios for the Autonomous Mission Operation (AMO) Test
Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)
Clinical Outcome Metrics for Optimization of Robust Training
Metric Development to Quantify Change in Mission Risk Due to a Physician-Trained Crew Medical Officer
Project Management Plan for the Medical Optimization Network for Space Telemedicine Resources
Validation of the NSBRI Astronaut Cardiovascular Health and Risk Modification (ASTRO-CHARM) Integrated Cardiovascular Risk Calculator
Medical Consumables Tracking
Assessing the impact of caffeine and other dietary factors on crew performance and sleep
Medical-501: We need to develop integrated exploration medical system models for the Moon and Mars.
System Foundation for Level of Care IV: Short-Duration Lunar Orbit
System Foundation for Level of Care IV: Long-Duration Lunar Orbital and Surface Operations delivered to HRP
Medical-601: We need an quantitative method for assessing whether the value of new exploration medical capability research is of sufficient benefit vs. cost to perform.
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.0
Medical-701: We need to increase inflight medical capabilities and identify new capabilities that (a) maximize benefit and/or (b) reduce “costs” on human system/mission/vehicle resources.
Risk of Intervertebral Disc Damage After Prolonged Spaceflight
Sonographic Astronaut Vertebral Examination
Medical Proficiency Training
Medical training methods for exploration missions
Telemedicine Workshop
Data mining for telementoring studies and practices
Assisted Medical Procedures
Integration of iRevive with the Lightweight Trauma Module
Electronic Procedures for Crewed Missions Beyond Low Earth Orbit (LEO)
Air/Fluid Separation in a Syringe in a Microgravity Environment
ExMC Support of Medical Scenarios for the Autonomous Mission Operation (AMO) Test
Clinical Outcome Metrics for Optimization of Robust Training
Metric Development to Quantify Change in Mission Risk Due to a Physician-Trained Crew Medical Officer
Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids
Adaptive Stress Training for Hazardous Conditions
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)
In-flight Blood Analysis Technology for Astronaut Health Monitoring
Ultrasound Fracture Diagnosis in Space
Intuitive Ultrasound Catalog for Autonomous Medical Care
Flexible Ultrasound System
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Development of Pressure Swing Adsorption Technology for Spaceflight Medical Oxygen Concentrators (Completed)
Portable Cathode-Air-Vapor-Feed Electrochemical Medical Oxygen Concentrator
Evaluation of Oxygen Concentrators at Altitude
Reusable Handheld Electrolytes and Lab Technology for Humans
Nanoscale Test Strips for Multiplexed Blood Analysis
IntraVenous Fluid GENeration for Exploration Missions
Smart Therapeutic Ultrasound Device for Mission-Critical Medical Care
Spaceflight Injectable Delivery System
Biomedical Sensors Requirements for Extravehicular Activities
Lunar Health Monitor: A Wearable System to Monitor Astronaut Health Status
Lightweight, Wearable Metal Rubber-Textile Sensor for In-Situ Lunar Autonomous Health Monitoring
Wearable Health Monitoring Systems
Oxygen Delivery System
IVGEN Post-Flight Analysis
Lightweight Trauma Module
Intraosseous (IO) Access Device Demonstration
Wideband Single Crystal Transducer for Bone Characterization
Exploration Laboratory Analysis
Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound [ULTRASOUND ICP/DENTINGER]
Multi-Use Near-Infrared Spectroscopy System for Spaceflight Health Applications
Biosensors for Exploration Medical System
JAXA Auscultation Data Review
Portable Quantitative Ultrasound with DXA/QCT and FEA Integration for Human Longitudinal Critical Bone Quality Assessment
Cell Phone-based Lateral Flow Assay for Blood Biomarker Detection
First Clinical Test of Feasibility of Ultrasound to Reposition Kidney Stones
Non-Invasive Monitoring of Intracranial Pressure with Volumetric Ophthalmic Ultrasound: Integration with NASA’s Flexible Ultrasound System (FUS)
Flexible Ultrasound System for Quantitative Diagnosis and Therapeutic Ultrasound
Tempus ISS Flight Technology Demonstration / ESA Collaboration
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.0
Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) V 1.x
Med02: We do not have the capability to provide a safe and effective pharmacy for exploration missions.
Medication Stability Analysis: Device
Retrospective Analysis of Medication Usage During Long Duration Spaceflight
Dose Tracker Application for Monitoring Crew Medication Usage, Symptoms and Adverse Effects During Missions
Med07: We do not have the capability to comprehensively process medically-relevant information to support medical operations during exploration missions.
Biosensors for Exploration Medical System
Medical Consumables Tracking
Exploration Medical System Demonstration
Middleware for Exploration Medical System
Electronic Medical Records for Exploration Medical System
Dental Imaging for Exploration Medical System
Assisted Medical Procedures
Distributed System for Spaceflight Biomedical Support
Exploration Medical System Demonstration (EMSD) Baseline Capability Evaluation using the Habitation Development Unit (HDU)
ExMC Support of Medical Scenarios for the Autonomous Mission Operation (AMO) Test
Exploration Medical Data Architecture
Med12: We do not have the capability to mitigate select medical conditions.
Portable Quantitative Ultrasound with DXA/QCT and FEA Integration for Human Longitudinal Critical Bone Quality Assessment
Flexible Ultrasound System for Quantitative Diagnosis and Therapeutic Ultrasound
Risk of Intervertebral Disc Damage After Prolonged Spaceflight
Sonographic Astronaut Vertebral Examination
Prevention of Renal Stone Complications in Space Exploration
Integrated Medical Model - Renal Stone Module
Wearable, Sustained Acoustic Medicine for Back Pain
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Ultrasound Fracture Diagnosis in Space
LADTAG Lunar Dust Health Standard
Clearance of Particles Depositing in the Human Lung in Low-Gravity
Improving Kidney Stone Detection in Space Analogs
Renal Stone Management Technology Development and Clinical Validation Study
rHealth One Flight Demonstration
ExMC 1.03: Inadequate information on the individual susceptibility to decompression sickness (DCS) in hypobaric environments relevant to space flight (CLOSED)
Data Mining/Identification of characteristics associated with susceptibility to hypobaric environments
ExMC 3.01: We do not know the optimal training methods for in-flight medical conditions identified on the Exploration Medical Condition List taking into account the crew medical officer’s clinical background (Closed)
Medical training methods for exploration missions
Medical Proficiency Training
ExMC Support of Medical Scenarios for the Autonomous Mission Operation (AMO) Test
ExMC 3.02: Lack of knowledge about the current state of the art in telementoring/telemedicine as a tool for assisting crewmembers to diagnose and treat medical conditions that occur in space flight (CLOSED)
Data mining for telementoring studies and practices
Telemedicine Workshop
ExMC 4.07: Limited wound care capability to improve healing following wound closure (Closed)
ExMC 4.10: Lack of rapid vascular access capability for space flight (CLOSED)
Intraosseous (IO) Access Device Demonstration
ExMC 4.11: Limited dental care capabilities (Closed)
Development of Methods/Technologies for Dental Conditions
ExMC 4.16: Lack of technique or procedure to draw injectable medication into a syringe without bubble formation or bubble removal prior to medication delivery (CLOSED)
Air/Fluid Separation in a Syringe in a Microgravity Environment
ExMC 4.22: Limited capability to diagnose and treat radiation sickness (Closed)
ExMC 4.24: Lack of knowledge regarding the treatment of conditions on the Exploration Medical Condition List in remote, resource poor environments (Closed)
Research Treatment of Relevant Medical Conditions in Remote, Resource Poor Environments
ExMC Support of Medical Scenarios for the Autonomous Mission Operation (AMO) Test
Risk of Ineffective or Toxic Medications During Long-Duration Exploration Spaceflight
Pharm-101: We need to determine the optimal packaging/storage strategy for medications in space that balances the needs of mitigating toxicity, preserving effectiveness, and minimizing resource “costs” (mass, volume, power, etc.).
Development of Methods/Technologies for Medication Stability and Shelf-life
Medical Consumables Tracking
Technology Watch
Stability of Pharmacotherapeutics and Nutrition Compounds-Pharm
FDA Comprehensive Stability Evaluation of Three Medications
Medication Stability Analysis: Device
Medication Aging Comparison Ground Validation Packaging
Development of Predictive Degradation Models and Determination of Bioequivalence of Pharmaceutical Preparations Contained in the Medical Kits on Board the International Space Station
Exploration Formulary v3.0 + Stoplight
Pharm-201: We need to establish an exploration formulary that identifies medications with maximal clinical benefit and minimal resource “costs” (mass, volume, etc.).
Medical Consumables Tracking
Technology Watch
Stability of Pharmacotherapeutics and Nutrition Compounds-Pharm
FDA Comprehensive Stability Evaluation of Three Medications
Medication Stability Analysis: Device
Medication Aging Comparison Ground Validation Packaging
Development of Methods/Technologies for Medication Stability and Shelf-life
Development of Predictive Degradation Models and Determination of Bioequivalence of Pharmaceutical Preparations Contained in the Medical Kits on Board the International Space Station
Exploration Formulary v3.0 + Stoplight
Pharm-301: We need to categorize all medications that are included in the iterative Exploration Candidate Formulary based upon the current state of knowledge of their effectiveness and safety in the spaceflight environment.
Development of Methods/Technologies for Medication Stability and Shelf-life
Medical Consumables Tracking
Technology Watch
Stability of Pharmacotherapeutics and Nutrition Compounds-Pharm
FDA Comprehensive Stability Evaluation of Three Medications
Medication Stability Analysis: Device
Medication Aging Comparison Ground Validation Packaging
Development of Predictive Degradation Models and Determination of Bioequivalence of Pharmaceutical Preparations Contained in the Medical Kits on Board the International Space Station
Exploration Formulary v3.0 + Stoplight
Pharm-401: We need to perform further research to understand and characterize the active pharmaceutical ingredient and degradation profiles of medications for which we have low to moderate confidence in their safety and effectiveness for exploration missions.
Development of Methods/Technologies for Medication Stability and Shelf-life
Medical Consumables Tracking
Technology Watch
Stability of Pharmacotherapeutics and Nutrition Compounds-Pharm
FDA Comprehensive Stability Evaluation of Three Medications
Medication Stability Analysis: Device
Medication Aging Comparison Ground Validation Packaging
Development of Predictive Degradation Models and Determination of Bioequivalence of Pharmaceutical Preparations Contained in the Medical Kits on Board the International Space Station
Exploration Formulary v3.0 + Stoplight
Pharm-501: We need to accurately characterize when astronauts use medications in space, why they use them, how they use them, whether they work, and if they cause any problems.
Dose Tracker Application for Monitoring Crew Medication Usage, Symptoms and Adverse Effects During Missions
Medical Consumables Tracking
Pharmacology Database
Retrospective Analysis of Medication Usage During Long Duration Spaceflight
Clinical Trial and FDA Approved Technology Watch
Monitoring FDA Adverse Event Reports
Pharm-601: We need to characterize the extent to which spaceflight alters pharmacokinetics and pharmacodynamics.
Risk of Renal Stone Formation
Renal-101: We do not have the capability to mitigate renal stones in spaceflight.
Integrated Medical Model - Renal Stone Module
Prevention of Renal Stone Complications in Space Exploration
Improving Kidney Stone Detection in Space Analogs
Renal Stone Management Technology Development and Clinical Validation Study
Risk Quantification Pilot with IMM for HSRB
B5: What is the current state of knowledge regarding renal stone formation due to spaceflight?
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
Data mining activities for Bone Discipline
N13: Can renal stone risk be decreased using nutritional countermeasures? (closed)
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
Space Biochemistry Profile
Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)
Integrated Nutrition: Development and Provision of Functional Foods to Mitigate Bone Loss on ISS Missions
Nutritional Status Assessment: SMO-016E
B6: What are the contributing factors other than loss of bone mineral density?
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
Data mining activities for Bone Discipline
B7: Is it necessary to increase crew fluid intake and, if possible, to what extent will it mitigate stone formation?
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
Data mining activities for Bone Discipline
B8: Do pharmaceuticals work effectively in spaceflight to prevent renal stones?
The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)
B9: What is the frequency of post-flight stone formation; the incidence and types of stones; and the time course of stone formation? How does stone formation correlate with food intake and hydration status?
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
B16: Can inhibitors of stone formation be sufficiently provided through dietary sources?
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
Med12: We do not have the capability to mitigate select medical conditions.
Portable Quantitative Ultrasound with DXA/QCT and FEA Integration for Human Longitudinal Critical Bone Quality Assessment
Flexible Ultrasound System for Quantitative Diagnosis and Therapeutic Ultrasound
Risk of Intervertebral Disc Damage After Prolonged Spaceflight
Sonographic Astronaut Vertebral Examination
Prevention of Renal Stone Complications in Space Exploration
Integrated Medical Model - Renal Stone Module
Wearable, Sustained Acoustic Medicine for Back Pain
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Ultrasound Fracture Diagnosis in Space
LADTAG Lunar Dust Health Standard
Clearance of Particles Depositing in the Human Lung in Low-Gravity
Improving Kidney Stone Detection in Space Analogs
Renal Stone Management Technology Development and Clinical Validation Study
rHealth One Flight Demonstration
Human Factors and Behavioral Performance
Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
BMed-101: Identify, quantify, and validate key selection factors for requisite performance on increasingly Earth-independent, long-duration, autonomous, and/or long-distance exploration missions
Adaptive Stress Training for Hazardous Conditions
Hyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station
BioNutritional Countermeasures Data Mining
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Behavioral Medicine Integrated Risk Review & Trade Study
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation
Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment
Cognitive Bias and Decision Making Training (Research Requirements)
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)
DoD Expeditionary Skills Partnership
Social, Family, and Behavioral Health Support NSCOR
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions
Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station
Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)
Self-Guided Multimedia Stress Management and Resilience Training
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Analog investigation of team resilience over time
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions
NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments
Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission
Assess Glymphatic Changes for Spaceflight
Astronaut Exploration Factors (Data Mining & Whitepaper)
BHP Radiation CNS Standard Measures Table RR
Biomarkers as Predictors of Resiliency and Susceptibility to Stress in Space Flight
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining
Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Research Review: Neurobehavioral Biomarkers Performance/Pathway
Research Review: NHP Model Brain Performance Pathways
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Effects of Long-duration Microgravity on Fine Motor Control Skills
Identification and Validation of HFBP Exploration Measures in HERA for Transport
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
HFBP Exploration Measures in HERA for Mars
Immune Function Data Mining
Behavioral Issues Associated with Long Duration Space Missions: Review and Analysis of Astronaut Journals - Extension and ISS-12
Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance
Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments
Bed Rest Combined with 0.5% CO2 as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases
Personality and biological predictors of resiliency to chronic stress among high-achieving adults
Environmental Factors Associated with Sleep Deficiency During Spaceflight
The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight
Sleep-Wake Actigraphy and Light Exposure During Spaceflight (ISS-12)
Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools
Developing and Validating Sensor-based Measurement Strategies for Team Member Selection
Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions
Effects of Long-Duration Spaceflight on Training Retention
Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation
Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II
Effects of Well-Being on Performance in ICE Environments (RR)
Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments
Growth and Resilience for Long Duration Exploration Missions(RR)
Meaningful Work for Long Duration Exploration Missions (RR)
Sleep-Wake Actigraphy and Light Exposure During Spaceflight
Speech monitoring of cognitive deficits and stress
Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration
Evidence Review on Identification of Psychosocial Characteristics in ICE Environments
Meta-Analysis of the effects of ICE environments
Selection Studies Retrospective
South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments
The Prediction of the Onset of Anxiety Disorders
White Paper on the Onset of Depression
A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments
The impact of human spaceflight on clonal hematopoiesis
Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
CNS Damage Signaling Neuropathology – Modeling Supplement
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
Private Astronaut Post-Mission Debrief Interviews
BMed-102: Identify and characterize key C/P/Psy/N outcome measures (biomarkers) and domains of relevance that are at risk due to spaceflight environmental stressors in exploration class missions and determine validated thresholds for identified biomarkers of adverse C/P/Psy/N outcomes to enable mission objectives and identify indicators of risk before progression to clinical levels of impairment.
Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system
NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments
Team and BHP Data Harmonization Update
Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation
Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation
Assess Glymphatic Changes for Spaceflight
Automated Transcription and Video Software Maturation
Standardized Behavioral Measures for Detecting Behavioral Health Risks during Exploration Missions
Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions
Biomarkers as Predictors of Resiliency and Susceptibility to Stress in Space Flight
Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain
Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment
Cognitive Assessment and Prediction to Promote Individualized Capability Augmentation and Reduce Decrement
Astrocytes as key mediators of central nervous system responses to space radiation
BioNutritional Countermeasures Data Mining
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
Effects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.
NHP CNS Radiation/Performance Data Mining
Future research (NSCOR) -- potential topics include RBEs, Glial cell response, stress response, cross-species homology, animal mood/social/cognition, sleep/stress/cognition, neural plasticity, dose rate effect for multiple measures
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
CBS Operational Performance Measures
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
Research Review: Neurobehavioral Biomarkers Performance/Pathway
Research Review: NHP Model Brain Performance Pathways
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior
Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation
Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles
Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function
Late CNS Risk Modeling
Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations
Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue
Individualized Real-Time Neurocognitive Assessment Toolkit (Cognition) for Space Flight Fatigue (ISS-12) (NSBRI)
Increasing Cognition Administration Order Flexibility
Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease
The Fine Motor Skills and Cognition Test Batteries: Normative Data and Interdependencies
Cognitive Performance and Crew Cohesion during Confinement in NASA's Human Research Program Human Exploration Research Analog (HERA)
Cognition Validation Study in High Performing Healthy Controls at Penn
Cognition Longitudinal Validation Study in High-Performing Healthy Controls at Penn
NASA's Behavioral Core Measures (BCM) Cognition Battery vs. WinSCAT: Validation, Norming, and Intra-individual Differences Across Cognitive Domains of Two Spaceflight Cognitive Assessment Tools in Higher Functioning Adults
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation
Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)
Epigenetic Control of Radiogenic Damage Processing in C. elegans
Towards a Real-Time Estimate of Circadian Phase During Spaceflight
Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation
Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G
Identification and Validation of HFBP Exploration Measures in HERA for Transport
HFBP Exploration Measures in HERA for Mars
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes
Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice
HZE particle exposure-induced improvement of pattern separation in mature mice: alterations in mission-relevant behaviors and neural circuitry
Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles
Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells
The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis
HZE Radiation Effects On Neuroinflammation: Role Of Cox-2
Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant
Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult
Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling
Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance
Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation
Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation
Use of Hypnotic and Alertness Medications in Military Populations (Research Requirements)
Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis
Monitoring Technologies COTS and NASA Tools Evaluation
Markers of Susceptibility to Neurobehavioral Decrements in Space Flight
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons
Neurobehavioral and CNS-Related Physiological Changes Following Space Radiation
Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments
Testing of Next Generation of Monitoring Tools for Deep Space & Planetary Exploration
Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions
Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight
High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo
High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB
Evaluation of the validity, acceptability and usability of bio-mathematical models to predict fatigue in an operational environment
Quantifying and Predicting Operationally-Relevant Performance in a Long-Duration Spaceflight Analog
NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System
Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei
Real-Time Estimation of the Effects of a Simulated Long-Duration Exploration Mission on Flight Performance, Workload, and Situation Awareness
Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration
NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation
Psychomotor Vigilance Test (PVT) on ISS
Psychomotor Vigilance Test (PVT) on ISS (Reaction Self-Test on ISS-12)
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight
Hadron-induced impairment of Executive Function:role of perturbed neurotransmission and the exacerbating impact of sleep deprivation
Sleep electroencephalography and near-infrared spectroscopy measurements for spaceflight and analogs
STARwatch to Deliver Objective Sleep Measures for Spaceflight Operations (SBIR Phase 2)
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders
Radiation Exposures in Space and the Potential of Central Nervous System Effects
Acute and long term outcomes of simulated deep space radiation exposure on latent viral CNS infection & CNS pathology
Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation
Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology
Space Radiation Risk Assessment Project-Cucinotta
The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation
Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice
Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II
Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS
Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure
Metrics and Methods for Real-Time Task Performance Assessment
Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions
Team State Lexical Analysis Software Refinement and Feasibility Testing
Team and Sleep Preliminary Literature Review
Impact of Space-Radiation Induced Alterations on Toxic Protein Accumulation Associated with Neurodegenerative Disease
Two-Hit Model of Alzheimer's Disease
Automated Video Analysis Software Maturation
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis
Asthenia Literature Review
CogGauge Enhancement
Individualized Behavioral Health Monitoring Tool
Investigate shifts in team cognitive processes over time (Research Requirements)
Multi-Modal Neurodiagnostic Tool for Stress Monitoring
Objective Detection, Evaluation and Countermeasures for In-flight Depression
Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)
Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation
Optical Computer Recognition of Performance Under Stress
Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight
Team Risk Standardized Measures Workshop
Voice Content Analysis Techwatch
Android App Incorporating the PVT to deliver individualized Fatigue Risk Management in Commercial Trucking
Assessing the Impact of Chronic Sleep Restriction on Sleep and Performance-Associated Regional Brain Activation Using Near-Infrared Spectroscopy (Postdoctoral Fellowship)
Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight
Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space
Development of a User Interface for the PVT SelfTest (PST)
Evidence Review on Biomarkers of Individual Vulnerabilities to Sleep Loss and Circadian Desynchronization
Individualized Fatigue Meter for Space Exploration (SBIR Phase II)
Integrated Cognitive Assessment: Combining Measurement, System, and Mission
Mathematical Modeling of Circadian/Performance Countermeasures
Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations
Workload and Scheduling Tools for Long Duration Missions (Research Requirements)
Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Long-Term Brain Structural and Functional Consequences of Spaceflight
CBS Supplement Homologous Species Biomarker Analyses
Behavioral and Physiological Factors Data Mining: Immune/Micro Assessment Capabilities
CNS Damage Signaling Neuropathology – Modeling Supplement
Establishing the impact of sleep disruptions on neural network connectivity when under cognitive loading
Effect of Space Radiation on Innate Immune System Homeostasis Drives Immune and Endothelial Cell Dysfunction and Neurodegeneration
Effects of Acute and Protracted Galactic Cosmic Radiation on Bone Strength.
Personalized Performance Optimization Platform (P-POP)
MATRIKS: Multi-Environment Virtual Training for Long Duration Exploration Missions
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Minipig Tissue Sharing
Epidemiologic Study on Cognitive Impairment related to the Interaction between Ionizing Radiation and Other Occupational Stressors
LaRC-MERA Multimodel Ensemble Risk
BMed-103: Identify validated, evidence-based countermeasures to prevent or treat adverse C/P/Psy/N conditions caused by single or combined exposures to spaceflight environmental stressors.
Adaptive Stress Training for Hazardous Conditions
Hyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation
Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation
Asynchronous Behavioral Health Treatment Techniques
Asynchronous Techniques for the Delivery of Empirically Supported Psychotherapies
Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station
Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain
Astrocytes as key mediators of central nervous system responses to space radiation
BioNutritional Countermeasures Data Mining
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
NHP CNS Radiation/Performance Data Mining
Future research (NSCOR) -- potential topics include RBEs, Glial cell response, stress response, cross-species homology, animal mood/social/cognition, sleep/stress/cognition, neural plasticity, dose rate effect for multiple measures
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
CBS Operational Performance Measures
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
Research Review: Neurobehavioral Biomarkers Performance/Pathway
Research Review: NHP Model Brain Performance Pathways
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation
Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation
Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles
Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function
Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations
Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease
Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment
Cognitive Bias and Decision Making Training (Research Requirements)
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)
Social, Family, and Behavioral Health Support NSCOR
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G
Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes
Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions
HZE particle exposure-induced improvement of pattern separation in mature mice: alterations in mission-relevant behaviors and neural circuitry
Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles
Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells
The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis
HZE Radiation Effects On Neuroinflammation: Role Of Cox-2
Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant
Understanding Key Components of Successful Autonomous Space Missions
Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station
Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)
Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons
Neurobehavioral and CNS-Related Physiological Changes Following Space Radiation
Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments
Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions
Non-Pharm Treatments Verification and Validation
NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System
Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei
Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration
Self-Guided Multimedia Stress Management and Resilience Training
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders
Radiation Exposures in Space and the Potential of Central Nervous System Effects
Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II
Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS
Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure
Analog investigation of team resilience over time
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Assessing Team Performance in Autonomous Environments
Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Follow-On Study)
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)
A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure
Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals
Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects
Self-Guided Depression Treatment on Long-Duration Spaceflights
Software Enabled Therapeutics for Psychiatry, Neurology, and Pain
Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration
Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II
Effects of Well-Being on Performance in ICE Environments (RR)
Evidence Review on Identification of Psychosocial Characteristics in ICE Environments
Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments
Growth and Resilience for Long Duration Exploration Missions(RR)
Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)
Investigate shifts in team motivation and morale over time (Research Requirements)
Meaningful Work for Long Duration Exploration Missions (RR)
Meta-Analysis of the effects of ICE environments
Neurobehavioral Conditions List for Exploration Missions (RR)
Selection Studies Retrospective
Sleep-Wake Actigraphy and Light Exposure During Spaceflight
South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments
Speech monitoring of cognitive deficits and stress
The Prediction of the Onset of Anxiety Disorders
White Paper on the Onset of Depression
Exposure of Male and Female Mice to 33-Particle Galactic Cosmic Radiation (GCR): Negative Impact on Translationally relevant Hippocampal-based Cognition and Prevention of GCR-induced Deficits by Acute Treatment with the Anti-inflammatory CDDO-EA
Exercise training as countermeasure for anti-tumor immune dysregulation due to isolation and confinement stress
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Behavioral and Physiological Factors Data Mining: Immune/Micro Assessment Capabilities
Effects of Acute and Protracted Galactic Cosmic Radiation on Bone Strength.
Personalized Performance Optimization Platform (P-POP)
MATRIKS: Multi-Environment Virtual Training for Long Duration Exploration Missions
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
Mars Adaptive Training Integrative Knowledge System (MATRIKS) to Improve Operational Performance and Its Neural Basis for Spaceflight
BMed-104: Identify design features and requirements of the habitat/vehicle and mission architecture to mitigate stressors impacting C/P/Psy/N health.
Adaptive Stress Training for Hazardous Conditions
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement
Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation
Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station
BioNutritional Countermeasures Data Mining
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
NHP CNS Radiation/Performance Data Mining
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation
Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment
Cognitive Bias and Decision Making Training (Research Requirements)
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)
Lighting Protocols for Exploration - HERA Campaign
Social, Family, and Behavioral Health Support NSCOR
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G
Identification and Validation of HFBP Exploration Measures in HERA for Transport
HFBP Exploration Measures in HERA for Mars
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions
HZE Radiation Effects On Neuroinflammation: Role Of Cox-2
Vehicle NHV and Habitability Assessment
Ultra-Short Light Pulses as Efficient Countermeasures for Circadian Misalignment and Objective Performance and Subjective Alertness Decrements
Lighting as a Cognitive and Behavioral Health Countermeasure
Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station
Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)
NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System
Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
Self-Guided Multimedia Stress Management and Resilience Training
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS
Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure
Analog investigation of team resilience over time
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons
Assessing Team Performance in Autonomous Environments
Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Follow-On Study)
Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects (pilot study)
Environmental Factors Evidence Review
Future Vehicle Environment (Research Requirements)
Net Habitable Volume Community of Practice
Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects
Phoenix Scout Lander: Countermeasures Testbed for Spaceflight Ground Controllers
Sensory Stimulation Augmentation Tools (RR)
Survey of On-Orbit Sleep Quality (Sleep Quality Questionnaire)
Virtual Reality (VR) Technologies for Enhancing Behavioral Health
Operational Evaluation of Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-Day Study (105-day Russian Chamber Study)
Optimizing Light for Long Duration Space Exploration
Blue Light for Enhancing Alertness in Space Missions
A Comprehensive Fatigue Management Program and an Evaluation of a Photic Countermeasure for Mission Controllers
The ISS Dynamic Lighting Schedule: An in-flight lighting countermeasure to facilitate circadian adaptation, improve sleep and enhance alertness and performance on the International Space Station
Feasibility Pilot Study on Acute Biological and Behavioral Responses to the Solid State Lighting Modules for the International Space Station
Sleep Workshop
Replacement Lighting for Research and Training
A Model of Circadian Disruption in the Space Environment
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
BMed-105: Identify validated medical or dietary countermeasures to mitigate spaceflight environmental stressors impacting C/P/Psy/N health.
Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions
Adaptive Stress Training for Hazardous Conditions
Hyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement
Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation
Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station
Standardized Behavioral Measures for Detecting Behavioral Health Risks during Exploration Missions
BioNutritional Countermeasures Data Mining
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
NHP CNS Radiation/Performance Data Mining
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
Characterize Workload on the International Space Station (ISS) (Research Requirements)
Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation
Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment
Cognitive Bias and Decision Making Training (Research Requirements)
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)
Social, Family, and Behavioral Health Support NSCOR
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G
HFBP Exploration Measures in HERA for Mars
Identification and Validation of HFBP Exploration Measures in HERA for Transport
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions
HZE Radiation Effects On Neuroinflammation: Role Of Cox-2
Vehicle NHV and Habitability Assessment
Lighting as a Cognitive and Behavioral Health Countermeasure
Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station
Use of Hypnotic and Alertness Medications in Military Populations (Research Requirements)
Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons
NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
Environmental Factors Associated with Sleep Deficiency During Spaceflight
The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight
Sleep-Wake Actigraphy and Light Exposure During Spaceflight
Self-Guided Multimedia Stress Management and Resilience Training
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS
Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure
Analog investigation of team resilience over time
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Assessing Team Performance in Autonomous Environments
Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Follow-On Study)
Exposure of Male and Female Mice to 33-Particle Galactic Cosmic Radiation (GCR): Negative Impact on Translationally relevant Hippocampal-based Cognition and Prevention of GCR-induced Deficits by Acute Treatment with the Anti-inflammatory CDDO-EA
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Personalized Performance Optimization Platform (P-POP)
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
BMed-106: Identify effective strategies to maintain personal relations/interactions to mitigate adverse C/P/Psy/N outcomes during increasingly Earth-independent long duration missions.
ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement
Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station
Social, Family, and Behavioral Health Support NSCOR
The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)
Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)
Family Training and Support Research Requirements
Assessment of the State of Communication Delay Research in Preparation for Missions Beyond Low Earth Orbit
BMed-107: Determine long-term changes and risks to astronaut health post-mission that retrospectively predicts individual susceptibility to adverse C/P/Psy/N outcomes and informs countermeasure implementation in current and future crews.
Adaptive Stress Training for Hazardous Conditions
Hyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation
Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation
Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station
Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain
Astrocytes as key mediators of central nervous system responses to space radiation
BioNutritional Countermeasures Data Mining
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
Effects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.
NHP CNS Radiation/Performance Data Mining
Future research (NSCOR) -- potential topics include RBEs, Glial cell response, stress response, cross-species homology, animal mood/social/cognition, sleep/stress/cognition, neural plasticity, dose rate effect for multiple measures
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
CBS Operational Performance Measures
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
Research Review: Neurobehavioral Biomarkers Performance/Pathway
Research Review: NHP Model Brain Performance Pathways
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior
Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation
Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation
Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles
Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function
Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations
Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease
Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment
Cognitive Bias and Decision Making Training (Research Requirements)
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)
Epigenetic Control of Radiogenic Damage Processing in C. elegans
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)
Social, Family, and Behavioral Health Support NSCOR
GCR Simulation Dose Rate Studies
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G
Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes
Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice
Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions
Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles
Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells
The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis
HZE Radiation Effects On Neuroinflammation: Role Of Cox-2
Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant
Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult
Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station
Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)
Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis
Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons
Neurobehavioral and CNS-Related Physiological Changes Following Space Radiation
Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions
Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei
Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration
NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation
Hadron-induced impairment of Executive Function:role of perturbed neurotransmission and the exacerbating impact of sleep deprivation
Self-Guided Multimedia Stress Management and Resilience Training
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders
Radiation Exposures in Space and the Potential of Central Nervous System Effects
Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation
Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology
Space Radiation Risk Assessment Project-Cucinotta
Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice
Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II
Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure
Analog investigation of team resilience over time
Impact of Space-Radiation Induced Alterations on Toxic Protein Accumulation Associated with Neurodegenerative Disease
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Assessing Team Performance in Autonomous Environments
Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Follow-On Study)
Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)
Post-Mission Behavioral Health Conditions Assessment (RR+Datamining)
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Epidemiologic Study on Cognitive Impairment related to the Interaction between Ionizing Radiation and Other Occupational Stressors
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
BMed-108: Identify and characterize the potential impacts of combined spaceflight environmental stressors to inform both validated threshold limits and countermeasure for adverse C/P/Psy/N outcomes.
Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions
NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments
Hyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission
Assess Glymphatic Changes for Spaceflight
BHP Radiation CNS Standard Measures Table RR
Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions
Biomarkers as Predictors of Resiliency and Susceptibility to Stress in Space Flight
BioNutritional Countermeasures Data Mining
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
Effects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.
NHP CNS Radiation/Performance Data Mining
Future research (NSCOR) -- potential topics include RBEs, Glial cell response, stress response, cross-species homology, animal mood/social/cognition, sleep/stress/cognition, neural plasticity, dose rate effect for multiple measures
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
CBS Operational Performance Measures
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs
Research Review: Neurobehavioral Biomarkers Performance/Pathway
Research Review: NHP Model Brain Performance Pathways
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
Computational Modeling for Behavioral Medicine Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Social, Family, and Behavioral Health Support NSCOR
Effects of Long-duration Microgravity on Fine Motor Control Skills
Identification and Validation of HFBP Exploration Measures in HERA for Transport
HFBP Exploration Measures in HERA for Mars
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
Immune Function Data Mining
Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant
Behavioral Issues Associated with Long Duration Space Missions: Review and Analysis of Astronaut Journals - Extension and ISS-12
Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance
Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments
Bed Rest Combined with 0.5% CO2 as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases
Personality and biological predictors of resiliency to chronic stress among high-achieving adults
Environmental Factors Associated with Sleep Deficiency During Spaceflight
The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight
Hadron-induced impairment of Executive Function:role of perturbed neurotransmission and the exacerbating impact of sleep deprivation
Sleep-Wake Actigraphy and Light Exposure During Spaceflight
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools
Radiation Exposures in Space and the Potential of Central Nervous System Effects
Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II
A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments
Effects of Long-Duration Spaceflight on Training Retention
Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II
Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation
Effects of Well-Being on Performance in ICE Environments (RR)
Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments
Growth and Resilience for Long Duration Exploration Missions(RR)
Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)
Investigate shifts in team motivation and morale over time (Research Requirements)
Meaningful Work for Long Duration Exploration Missions (RR)
Neurobehavioral Conditions List for Exploration Missions (RR)
Sleep-Wake Actigraphy and Light Exposure During Spaceflight (ISS-12)
Speech monitoring of cognitive deficits and stress
Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.
Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Measuring Transcutaneous Partial Pressure of Carbon Dioxide (PCO2) to Estimate Arterial PCO2 during Spaceflight
Long-Term Brain Structural and Functional Consequences of Spaceflight
Exposure of Male and Female Mice to 33-Particle Galactic Cosmic Radiation (GCR): Negative Impact on Translationally relevant Hippocampal-based Cognition and Prevention of GCR-induced Deficits by Acute Treatment with the Anti-inflammatory CDDO-EA
Understanding the Impact of Hypobaric Hypoxia and Confinement Stress on Intestinal Immunity and Host-Microbiome Interactions
Exercise training as countermeasure for anti-tumor immune dysregulation due to isolation and confinement stress
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
CBS Supplement Homologous Species Biomarker Analyses
Behavioral and Physiological Factors Data Mining: Immune/Micro Assessment Capabilities
CNS Damage Signaling Neuropathology – Modeling Supplement
Establishing the impact of sleep disruptions on neural network connectivity when under cognitive loading
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
Epidemiologic Study on Cognitive Impairment related to the Interaction between Ionizing Radiation and Other Occupational Stressors
Assessing the impact of caffeine and other dietary factors on crew performance and sleep
Private Astronaut Post-Mission Debrief Interviews
Characterizing and mitigating the interactive impacts of fatigue- and altered gravity-related stressors on sensorimotor, behavioral, and operational outcomes (Mehta)
Risk of Adverse Outcomes Due to Inadequate Human Systems Integration Architecture
HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.
HCAAM: Conversation analysis to measure and manage trust in virtual assistants
HCAAM: Crew Autonomy through Self-Scheduling: Guidelines for Crew Scheduling Performance Envelope and Mitigation Strategies
HCAAM: Enhancing Situation Awareness of Automated Procedures using Adaptive Multimodal Augmented Reality Displays
HCAAM: Responsive multimodal human-automation communication for augmenting human situation awareness in nominal and off nominal scenarios
HCAAM: Using a Human Capabilities Framework to Quantify Crew Task Performance in Human-Robotic Systems
HCAAM: Virtual Assistant for Spacecraft Anomaly Treatment during Long Duration Exploration Missions
Computational Model for Spacecraft/Habitat Volume
Wearable Kinematic Systems for Quantifying 3-D Space Utilization in the Microgravity Environment
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
A Tool for the Automated Collection of Space Utilization Data
Automatic Video-based Motion Analysis
Semantic Language and Tools for Reporting Human Factors Incidents - Phase III
Habitability-Human Factors and Habitability Assessment Tool
Semantic Language and Tools for Reporting Human Factors Incidents
Interactive Space Vehicle Design Tool with Virtual Reality
Automated Video Analysis Software Maturation
Human Factors Analysis Support Tool (H-FAST) Phase III
Human Factors Analysis Support Tool (H-FAST)
Usability Evaluation
HFBP HCAAM Capabilities Refinement
Human-Centered Design in an Agile Process
Project FUSION: Facilitating Unified Systems of Interdependent Organizational Networks
Team Task Switching in Astronaut Crews on the International Space Station: Integrating Multiteam Membership, Multiteam Systems, Multitasking, & Multidimensional Networks to Monitor & Enable Functional Work Shifts in Astronaut Crews
Understanding and Preventing Crew Member Task Entrainment
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
CBS Operational Performance Measures
Spaceflight Resource Management Training
Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions
Training Needs Analysis
Developing and Validating Specific Medical Event Management Training Protocols for Flight Crews on Deep Space, Long-Duration Space Exploration Missions (NSBRI-Yule)
Astronaut performance standards
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
Evidence-based Metrics Toolkit for Measuring Safety and Efficiency in Human-Automation Systems
Metrics and Methods for Real-Time Task Performance Assessment
Automation Interface Design Tools Development
Human – Automation Interactions and Performance Analysis of Lunar Lander Supervisory Control
Ensuring Human-Automation/Robotic Integration Safety Standards in Spaceflight
Quantifying Effective Crew Performance with Advanced Automated-Robotic Systems Risk
Cognitive Assessment and Prediction to Promote Individualized Capability Augmentation and Reduce Decrement
Multi-Team System (Research Requirements)
Spaceprint: Development and Validation of a Tool to Predict, Evaluate, and Mitigate Excessive Workload Effects
Workload Tools and Guidelines
Evaluation of Crew-Centric Onboard Mission Operations Planning and Execution Tool
Workload and Scheduling Tools for Long Duration Missions (Research Requirements)
Team State Lexical Analysis Software Refinement and Feasibility Testing
Automated Transcription and Video Software Maturation
Comfort and Human factors AstroRad Radiation Garment Evaluation (CHARGE) on ISS (CASIS)
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Human Factors Vehicle/Habitat Design Assessment Rubric – Phase 2
Human Systems Integration Architecture: State of the Art Assessment for Needs Analysis
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
NASA Spaceflight Human Centered Integration & Design Requirements Scale: Validation and Development
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Interface Consistency (Phase I): Characterization and Measurement
AR/VR and Hybrid Reality for Verification Assessments: Phase I
3D scanning system to assess gravity-dependent body shape changes
HSIA-201: We need to evaluate the demands of future exploration habitat/vehicle systems and mission scenarios (e.g. increased automation, multi-modal communication) on individuals and teams, and determine the risks these demands pose to crew health and performance.
HCAAM: Conversation analysis to measure and manage trust in virtual assistants
HCAAM: Enabling Autonomous Crew Task Performance with Multimodal Electronic Procedure Countermeasures
HCAAM: Enhancing Situation Awareness of Automated Procedures using Adaptive Multimodal Augmented Reality Displays
HCAAM: Responsive multimodal human-automation communication for augmenting human situation awareness in nominal and off nominal scenarios
HCAAM: Using a Human Capabilities Framework to Quantify Crew Task Performance in Human-Robotic Systems
HCAAM: Virtual Assistant for Spacecraft Anomaly Treatment during Long Duration Exploration Missions
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Vehicle NHV and Habitability Assessment
Display Reading Performance Under Lateral Whole-Body Vibration Due to 12-Hz Thrust Oscillation
Combined whole-body vibration plus G-loading influences on visual performance and operator ratings
SDBI 1904 - Human Factors Assessment of Vibration Effects on Visual Performance During Launch
Space Craft Internal Acoustic Environment
Computational Modeling to Limit the Impact Displays and Indicator Lights Have on Habitable Volume Operational Lighting Constraints
Robust Human-System Interface Design for Spaceflight-Induced Environments (Interface Design-Stone, Completed)
Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, and Neural Bases (NeuroMapping-Flight-Seidler)
Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler)
HCAAM: Crew Autonomy through Self-Scheduling: Guidelines for Crew Scheduling Performance Envelope and Mitigation Strategies
Speech Alarms Pilot Study
Multimodal Augmented Displays for Surface Telerobotic Missions
Displays and Controls Interfaces
Enhancement of Spatial Orientation Capability of Astronauts on the Lunar Surface
Information Presentation - Electronic Procedures and Fault Management
Information Presentation – Controls Technology Survey and Testing
Information Presentation – Displays Development (Visual and Auditory)
Information Presentation – Human Performance Modeling
Modeling and mitigating spatial disorientation in low g environments
Sensorimotor Displays and Controls to Enhance the Safety of Human/Machine Cooperation During Lunar Landing (Lander D&C-Young, Completed)
Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)
Evaluation of Crew-Centric Onboard Mission Operations Planning and Execution Tool
Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids
HFBP HCAAM Capabilities Refinement
Cognitive Aid Design Using Augmented Reality to Support Attention
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Human Systems Integration Architecture: Concept of Operations
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
HSIA-301: We need to determine the on-board, intelligent systems that will support crew health and performance, and we need to establish the thresholds that will define how these systems should be implemented (including in-mission and at landing).
HCAAM: Responsive multimodal human-automation communication for augmenting human situation awareness in nominal and off nominal scenarios
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
Future Vehicle Environment (Research Requirements)
Team NHV (Research Requirements)
Human Systems Integration Architecture: State of the Art Assessment for Needs Analysis
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
Human System Integration Architecture: Leveraging Lessons Learned from the First ISS Expedition for Long-Duration Exploration Missions
Identifying Risks of Commercial Crew Integration for Spaceflight Operations
HSIA-401: We need to determine how HSI can be applied in the vehicle/habitat and computer interface Design Phase to mitigate potential decrements in operationally-relevant performance (e.g. problem-solving, execution procedures), during increasingly earth-independent, future exploration missions (including in-mission and at landing).
HCAAM: Conversation analysis to measure and manage trust in virtual assistants
HCAAM: Enabling Autonomous Crew Task Performance with Multimodal Electronic Procedure Countermeasures
HCAAM: Enhancing Situation Awareness of Automated Procedures using Adaptive Multimodal Augmented Reality Displays
HCAAM: Responsive multimodal human-automation communication for augmenting human situation awareness in nominal and off nominal scenarios
HCAAM: Using a Human Capabilities Framework to Quantify Crew Task Performance in Human-Robotic Systems
HCAAM: Virtual Assistant for Spacecraft Anomaly Treatment during Long Duration Exploration Missions
Quantification of In-flight Physical Changes - Anthropometry and Neutral Body Posture (NBP)
Spinal Elongation and its Effects on Seated Heights in a Microgravity Environment
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE
Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, and Neural Bases (NeuroMapping-Flight-Seidler)
Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler)
HCAAM: Crew Autonomy through Self-Scheduling: Guidelines for Crew Scheduling Performance Envelope and Mitigation Strategies
Speech Alarms Pilot Study
Multimodal Augmented Displays for Surface Telerobotic Missions
Displays and Controls Interfaces
Sensorimotor Displays and Controls to Enhance the Safety of Human/Machine Cooperation During Lunar Landing (Lander D&C-Young, Completed)
Enhancement of Spatial Orientation Capability of Astronauts on the Lunar Surface
Information Presentation - Electronic Procedures and Fault Management
Information Presentation – Controls Technology Survey and Testing
Information Presentation – Displays Development (Visual and Auditory)
Information Presentation – Human Performance Modeling
Modeling and mitigating spatial disorientation in low g environments
Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)
Evaluation of Crew-Centric Onboard Mission Operations Planning and Execution Tool
Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids
HFBP HCAAM Capabilities Refinement
Cognitive Aid Design Using Augmented Reality to Support Attention
Sensory Manipulation as a Countermeasure to Robot Teleoperation Delays
Human Systems Integration Architecture: Concept Validation and Implementation Evaluation
Human Systems Integration Architecture Needs Analysis: Anomaly Response Analysis Mapping to Operations Beyond Low-Earth Orbit
Human Systems Integration Architecture: Capturing Crew Responses on Artemis Missions
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
NASA Spaceflight Human Centered Integration & Design Requirements Scale: Validation and Development
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Human Systems Integration Architecture: Concept of Operations
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Interface Consistency (Phase I): Characterization and Measurement
AR/VR and Hybrid Reality for Verification Assessments: Phase I
Assessment of the State of Communication Delay Research in Preparation for Missions Beyond Low Earth Orbit
3D scanning system to assess gravity-dependent body shape changes
Private Astronaut Post-Mission Debrief Interviews
HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).
HCAAM: Conversation analysis to measure and manage trust in virtual assistants
HCAAM: Crew Autonomy through Self-Scheduling: Guidelines for Crew Scheduling Performance Envelope and Mitigation Strategies
HCAAM: Enabling Autonomous Crew Task Performance with Multimodal Electronic Procedure Countermeasures
HCAAM: Responsive multimodal human-automation communication for augmenting human situation awareness in nominal and off nominal scenarios
HCAAM: Using a Human Capabilities Framework to Quantify Crew Task Performance in Human-Robotic Systems
Generalizable Skills and Knowledge for Exploration Missions
Project FUSION: Facilitating Unified Systems of Interdependent Organizational Networks
Human Performance Data Project
Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids
Electronic Procedures for Crewed Missions Beyond Low Earth Orbit (LEO)
Evaluation of the validity, acceptability and usability of bio-mathematical models to predict fatigue in an operational environment
Crew Scheduling Tools
Evaluation of Crew-Centric Onboard Mission Operations Planning and Execution Tool
Workload and Scheduling Tools for Long Duration Missions (Research Requirements)
Design and Evaluation of Automated Electronic Checklists for Robotics Operations
Human Systems Integration Architecture: Concept Validation and Implementation Evaluation
Human Systems Integration Architecture: Capturing Crew Responses on Artemis Missions
Human Systems Integration Architecture: State of the Art Assessment for Needs Analysis
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Human Systems Integration Architecture: Concept of Operations
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
Human System Integration Architecture: Leveraging Lessons Learned from the First ISS Expedition for Long-Duration Exploration Missions
Identifying Risks of Commercial Crew Integration for Spaceflight Operations
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
HSIA-601: We need to determine individual and team-based Human System Integration (HSI) training procedures, regimens, and standards that are required pre- and in-mission, and post-landing to help reduce demands on crew (e.g., neurocognitive, time); support meaningful work during long-duration missions; and mitigate potential decrements in operationally-relevant performance (e.g., training retention, problem-solving, procedure execution) during increasingly earth-independent, future exploration missions.
Facilitating the Synergistic Side of Cultural Diversity in LDSE: Identification of Challenges and Development of Cultural Training
Team Task Switching in Astronaut Crews on the International Space Station: Integrating Multiteam Membership, Multiteam Systems, Multitasking, & Multidimensional Networks to Monitor & Enable Functional Work Shifts in Astronaut Crews
Understanding and Preventing Crew Member Task Entrainment
Adaptive Stress Training for Hazardous Conditions
Customized Refresher and Just-in-Time Training for Long-Duration Spaceflight Crews (NSBRI, Robinson)
Medical Proficiency Training
Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station
Protocols for Asynchronous Communication in Space Operations: Communication Analysis
Serious Games for Team Training
In-Mission Training Methodologies
Deep Space Team Training
Pre-Mission Training Methodologies
DoD Expeditionary Skills Partnership
Just in Time Simulation Platform
Developing and Validating Specific Medical Event Management Training Protocols for Flight Crews on Deep Space, Long-Duration Space Exploration Missions (NSBRI-Yule)
Autonomous Diagnostic Imaging Performed by Untrained Operators Using Augmented Reality as a Form of ‘Just-in-Time' Training (NSBRI-Martin)
Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids
Effects of Long-Duration Spaceflight on Training Retention
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Astronaut performance standards
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
Cognitive Aid Design Using Augmented Reality to Support Attention
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Manual Crew Override of Vehicle Landings following G-transitions - ISS (Wood)
Human Systems Integration Architecture: State of the Art Assessment for Needs Analysis
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Human Systems Integration Architecture: Concept of Operations
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
Human System Integration Architecture: Leveraging Lessons Learned from the First ISS Expedition for Long-Duration Exploration Missions
MATRIKS: Multi-Environment Virtual Training for Long Duration Exploration Missions
MATRIKS: A Haptic Sensory Supplement to Optimize In-Flight Adaptive Training for Human Control of Spacecraft Robotic Arms
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Mars Adaptive Training Integrative Knowledge System (MATRIKS) to Improve Operational Performance and Its Neural Basis for Spaceflight
Private Astronaut Post-Mission Debrief Interviews
HSIA-701: We need to determine how human-automation-robotic systems can be optimized for effective enhancement and monitoring of crew capabilities, health, and performance, during increasingly earth-independent, future exploration missions (including in-mission and at landing).
HCAAM: Conversation analysis to measure and manage trust in virtual assistants
HCAAM: Crew Autonomy through Self-Scheduling: Guidelines for Crew Scheduling Performance Envelope and Mitigation Strategies
HCAAM: Enhancing Situation Awareness of Automated Procedures using Adaptive Multimodal Augmented Reality Displays
HCAAM: Responsive multimodal human-automation communication for augmenting human situation awareness in nominal and off nominal scenarios
HCAAM: Virtual Assistant for Spacecraft Anomaly Treatment during Long Duration Exploration Missions
Objective Function Allocation Method for Human-Automation/Robotic Interaction using Work Models that Compute
Needs Assessment and Work Allocation Tools for Mission Operations and Procedures
Automation in Procedures: Guidelines for Allocating Tasks for Performance
Space Human Factors and Habitability MIDAS-FAST: Development and Validation of a Tool to Support Function Allocation
Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust During Robotic Supervisory Control
Ensuring Human-Automation/Robotic Integration Safety Standards in Spaceflight
Assessing and Mitigating the Impact of Transmission Delays on Teleoperations
Assessment, evaluation, and development of methodologies, metrics, and tools available for use in multi-agent (human and robotic) teaming
Multimodal Augmented Displays for Surface Telerobotic Missions
Advanced Displays for Efficient Training and Operation of Robotic Systems (Robotic Systems-Oman, Completed)
Team Member/ Vehicle Interaction
Quantifying Effective Crew Performance with Advanced Automated-Robotic Systems Risk
Human-automation and Robotic Integration Design Reference Mission Task Scoping
Human-automation and Robotic Integration Trade Study Analysis
Benchmarking Effective Human Performance with Advanced Automated-Robotic Systems
Sensory Manipulation as a Countermeasure to Robot Teleoperation Delays
Human Systems Integration Architecture: State of the Art Assessment for Needs Analysis
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Human Systems Integration Architecture: Concept of Operations
Data Harmonization of Habitability and Sensory Stimulation Research Data Phase I
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Multimodal Alert Design
Human System Integration Architecture: Leveraging Lessons Learned from the First ISS Expedition for Long-Duration Exploration Missions
HSIA-801: Given each crewmember will experience multiple spaceflight hazards (e.g. radiation, isolation and confinement, altered gravity), we need to evaluate and identify how HSI can further characterize and/or mitigate additive and/or synergistic effects of the spaceflight environment, for increasingly earth-independent, future exploration missions (including in-mission and at landing).
Effects of Long-duration Microgravity on Fine Motor Control Skills
Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids
Cognitive Aid Design Using Augmented Reality to Support Attention
Maturation of Habitat/Vehicle Standards and Guidelines for Exploration Missions
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Risk of Injury from Dynamic Loads
DL-101: We do not understand the risk of injury associated with crewed vehicle landings and how this risk relates to the desired acceptable risk.
Definition of Acceptable Risk Summit
Soyuz Landing Injury Risk Characterization
Investigation of Occupant Injury Risk in the Soyuz Vehicle and Comparison to Commercial Crew Designs
Development of Injury Assessment Reference Values for the Neck Applicable to Spaceflight Use Cases
Development of Injury Assessment Reference Values for the Lower Extremities Applicable to Spaceflight Use Cases
Development of Injury Assessment Reference Values for the Lumbar Spine Applicable to Spaceflight Use Cases
DL-201: We do not know how load dynamics and sex differences affect injury risk in spaceflight conditions and do not have adequate injury assessment reference values (IARVs) to mitigate the increased risk of injury to the crew.
Occupant Protection Data Mining and Modeling Project
ATD Injury Metric Development
ATD Injury Metric Sensitivity and Extensibility
Comparison of Biodynamics Models Using Automotive Racing Crash Data
Development of Injury Assessment Reference Values for the Neck Applicable to Spaceflight Use Cases
Development of Injury Assessment Reference Values for the Lower Extremities Applicable to Spaceflight Use Cases
Development of Injury Assessment Reference Values for the Lumbar Spine Applicable to Spaceflight Use Cases
DL-301: We do not have an identified, validated and standardized approach for vehicle instrumentation and biodynamic data collection, and predictive analytic biodynamic modeling that would allow for specific risk injury prediction by mission-phase, crew functionality post-landing, and vehicle design.
NESC/Hybrid III Testing & Model Characterization
NESC/Suit Characterization
Occupant Protection Data Mining and Modeling Project
ATD Injury Metric Sensitivity and Extensibility
Investigation of Occupant Injury Risk in the Soyuz Vehicle and Comparison to Commercial Crew Designs
Development of Injury Assessment Reference Values for the Neck Applicable to Spaceflight Use Cases
Development of Injury Assessment Reference Values for the Lower Extremities Applicable to Spaceflight Use Cases
Development of Injury Assessment Reference Values for the Lumbar Spine Applicable to Spaceflight Use Cases
DL-401: We do not know the extent to which multiple spaceflight hazards (e.g., spaceflight deconditioning, bone loss, radiation exposure, altered gravity) may interact to synergistically decrease injury tolerance for off-nominal dynamic landing loads, increasing risk to crew’s performance in mission-completing actions immediately after landing.
Vertebral strength and fracture risk following long duration spaceflight
Quantitative CT and MRI-based Modeling Assessment of Dynamic Vertebral Strength and Injury Risk Following Long-Duration Spaceflight
Risk of Intervertebral Disc Damage After Prolonged Spaceflight
Quantification of In-flight Physical Changes - Anthropometry and Neutral Body Posture (NBP)
Deconditioning Summit
Sonographic Astronaut Vertebral Examination
Investigation of Occupant Injury Risk in the Soyuz Vehicle and Comparison to Commercial Crew Designs
3D scanning system to assess gravity-dependent body shape changes
Risk of Performance and Behavioral Health Decrements Due to Inadequate Cooperation, Coordination, Communication, and Psychosocial Adaptation within a Team
Team-101: We need to understand the key threats, indicators, and evolution of the team throughout its life cycle for shifting autonomy and interface with automation in increasingly earth independent, long duration exploration missions.
NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments
Team and BHP Data Harmonization Update
Astronaut performance standards
Development of an Objective Behavioral Assay of Cohesion to Enhance Composition, Task Performance, and Psychosocial Adaptation in Long-Term Work Groups
A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments
A US-Russian Collaborative Proposal for Data Collection in HERA: The Relationship between Composition, Interpersonal Relations, and Team Effectiveness in Space Crews
AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis
Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station
Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration
CREWS: Crew Recommender for Effective Work in Space
Data mining of Benchmarking Studies (Research Requirements)
Developing, Maintaining, and Restoring Team Cohesion
Examination of Cultural Interactions Using Archival Data Footage on ISS
Facilitating the Synergistic Side of Cultural Diversity in LDSE: Identification of Challenges and Development of Cultural Training
Field test of a simple, rapid, and objective behavioral assay of group cohesion in an antarctic space analog environment
Growth and Resilience for Long Duration Exploration Missions(RR)
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
Investigate shifts in team cognitive processes over time (Research Requirements)
Investigate shifts in team motivation and morale over time (Research Requirements)
Investigating the Influence of Personality on Performance Within the Astronaut Population
Job Analysis
Key Contributors to the Maintenance and Regulation of Team Function and Performance on Long Duration Exploration Missions
Literature Review and Operational Assessment of Psychosocial Strategies related to BHP
Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions
Maintaining Team Performance and Functioning during Changing Team Dynamics and Interpersonal Relationships
Measuring, Monitoring, and Regulating Teamwork for Long Duration Missions
Monitoring and Regulating Teamwork
Multi-Team System (Research Requirements)
Non-Pharm Treatments Verification and Validation
Project FUSION: Facilitating Unified Systems of Interdependent Organizational Networks
Protocols for Asynchronous Communication in Space Operations: Communication Analysis
Psychosocial Factors Model Development (Research Requirements)
Psychosocial Performance Factors in Space Dwelling Groups (PI Roma)
Risk Assessment – Task Performance, Teamwork, and Psychosocial Performance
SCALE: Shared Cognitive Architectures for Long-term Exploration
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
Study of shifts in team shared mental models over long durations (Research Requirements)
Team Adaptation and Resilience (Research Requirements)
Team and Sleep Preliminary Literature Review
Team NHV (Research Requirements)
Team Risk Standardized Measures Workshop
Team Self - Maintenance (Research Requirements)
Team Task Switching in Astronaut Crews on the International Space Station: Integrating Multiteam Membership, Multiteam Systems, Multitasking, & Multidimensional Networks to Monitor & Enable Functional Work Shifts in Astronaut Crews
Team Trust (Research Requirements)
Understanding and Preventing Crew Member Task Entrainment
Using Analog Missions to Develop Effective Team Composition Strategies for Long Duration Space Exploration
Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Identifying Risks of Commercial Crew Integration for Spaceflight Operations
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
Assessment of the State of Communication Delay Research in Preparation for Missions Beyond Low Earth Orbit
Private Astronaut Post-Mission Debrief Interviews
Team-102: We need to identify a set of quantifiable and validated measures, based on 5-12 key indicators of mission-relevant and identified spaceflight acceptable thresholds (or ranges) of team function, to effectively monitor and measure team health and performance of integrated NASA and commercial/private crews, during shifting autonomy in increasingly earth independent, long duration exploration missions.
AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis
Analog Validation Study of Team Measures
Astronaut performance standards
Automated Behavior and Cohesion Assessment Tools
Automated Transcription and Video Software Maturation
Automated Video Analysis Software Maturation
Behavior Tracking Software Enhancement and Integration of a Feedback Module
CBS Operational Performance Measures
Developing, Maintaining, and Restoring Team Cohesion
Development of an Objective Behavioral Assay of Cohesion to Enhance Composition, Task Performance, and Psychosocial Adaptation in Long-Term Work Groups
Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools
Field test of a simple, rapid, and objective behavioral assay of group cohesion in an antarctic space analog environment
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
HFBP Exploration Measures in HERA for Mars
Identification and Validation of HFBP Exploration Measures in HERA for Transport
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
Key Contributors to the Maintenance and Regulation of Team Function and Performance on Long Duration Exploration Missions
Literature Review and Operational Assessment of Monitoring Tools and Technologies related to BHP
Measuring, Monitoring, and Regulating Teamwork for Long Duration Missions
Monitoring and Regulating Teamwork
DoD Expeditionary Skills Partnership
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
Standardized Behavioral Measures for Detecting Behavioral Health Risks during Exploration Missions
Team Cohesion Monitoring Badge: Development of Galvanic Skin Resistance Modality
Measures and Thresholds Mars Capstone: Data Aggregation and Crew-Facing Data
Team State Lexical Analysis Software Refinement and Feasibility Testing
Testing of Next Generation of Monitoring Tools for Deep Space & Planetary Exploration
Updated Data Mining Review of Team Benchmarking Studies
Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Artificial intelligence for tracking micro-behaviors in longitudinal data and predicting their effect on well-being and team performance
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Human System Integration Architecture: Leveraging Lessons Learned from the First ISS Expedition for Long-Duration Exploration Missions
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Team-103: We need to identify psychological and psychosocial factors, measures, and combinations thereof for use in selecting individuals and composing highly effective crews most likely to maintain team function during shifting autonomy in increasingly earth independent, long duration exploration missions.
A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments
A US-Russian Collaborative Proposal for Data Collection in HERA: The Relationship between Composition, Interpersonal Relations, and Team Effectiveness in Space Crews
Analog investigation of team resilience over time
Astronaut Exploration Factors (Data Mining & Whitepaper)
Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration
CREWS: Crew Recommender for Effective Work in Space
Developing and Validating Sensor-based Measurement Strategies for Team Member Selection
Development of an Objective Behavioral Assay of Cohesion to Enhance Composition, Task Performance, and Psychosocial Adaptation in Long-Term Work Groups
Facilitating the Synergistic Side of Cultural Diversity in LDSE: Identification of Challenges and Development of Cultural Training
Field test of a simple, rapid, and objective behavioral assay of group cohesion in an antarctic space analog environment
Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK
Growth and Resilience for Long Duration Exploration Missions(RR)
HFBP Exploration Measures in HERA for Mars
Identification and Validation of HFBP Exploration Measures in HERA for Transport
Investigation of effective team composition for long duration exploration missions (Research Requirements)
Leader-Followership Team Composition (Research Requirements)
Leadership-Followership: Moving Beyond Traditional Leadership to Build Highly Functioning Autonomous Teams
Metrics for Composing Teams
NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments
SCALE: Shared Cognitive Architectures for Long-term Exploration
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
Using Analog Missions to Develop Effective Team Composition Strategies for Long Duration Space Exploration
Virtual Reality (VR) Technologies for Enhancing Behavioral Health
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Personalized Performance Optimization Platform (P-POP)
Identifying Risks of Commercial Crew Integration for Spaceflight Operations
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
Private Astronaut Post-Mission Debrief Interviews
Team-104: We need to identify validated ground-based and in-flight training methods for both preparatory and sustaining team function during shifting autonomy in increasingly earth independent, long duration exploration missions.
Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station
Astronaut performance standards
CBS Operational Performance Measures
Deep Space Team Training
Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools
Effects of Long-Duration Spaceflight on Training Retention
Facilitating the Synergistic Side of Cultural Diversity in LDSE: Identification of Challenges and Development of Cultural Training
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
In-Mission Training Methodologies
Job Analysis
Literature Review and Operational Assessment of Countermeasures Related to BHP
Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions
Optimizing Crew Performance in Long Duration Space Exploration: Best Practices for Team Training and Cohesion Measurement
DoD Expeditionary Skills Partnership
Pre-Mission Training Methodologies
SCALE: Shared Cognitive Architectures for Long-term Exploration
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
Social, Family, and Behavioral Health Support NSCOR
Study of shifts in team shared mental models over long durations (Research Requirements)
Training and Culture (Research Requirements)
Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures
Training Needs Analysis
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Composing Teams with TEAMSTaR: Tool for Evaluating and Mitigating Space Team Risk
Identifying Risks of Commercial Crew Integration for Spaceflight Operations
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Integrated NASA and Private Astronaut Crews Readiness Needs Assessment
Private Astronaut Post-Mission Debrief Interviews
Team-105: We need to identify a set of countermeasures to support team function and enable multiple distributed teams to manage shifting levels of autonomy for all phases of increasingly earth independent, long duration exploration missions.
A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments
A Scheduling and Planning Tool in NEEMO 14 – A Simulated Space Environment
AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis
ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement
Assessing Team Performance in Autonomous Environments
Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station
Autonomy Literature Review Requirements
Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration
Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study
Crew Interactions and Autonomy During Long-Duration Isolation and Confinement (105-Day Russian Chamber Study)
Developing, Maintaining, and Restoring Team Cohesion
Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools
Effects of high vs. Low Autonomy on Crewmember Performance in analogues
Facilitating the Synergistic Side of Cultural Diversity in LDSE: Identification of Challenges and Development of Cultural Training
HCAAM: Crew Autonomy through Self-Scheduling: Guidelines for Crew Scheduling Performance Envelope and Mitigation Strategies
HCAAM: Enabling Autonomous Crew Task Performance with Multimodal Electronic Procedure Countermeasures
Investigate effects on performance and countermeasures for switching between individual and team tasks (Research Requirements)
Literature Review and Operational Assessment of Communication Strategies related to BHP
Measuring, Monitoring, and Regulating Teamwork for Long Duration Missions
Monitoring and Regulating Teamwork
Protocols for Asynchronous Communication in Space Operations: Communication Analysis
Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions
Social, Family, and Behavioral Health Support NSCOR
Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation
Team Member/ Vehicle Interaction
Team Task Switching in Astronaut Crews on the International Space Station: Integrating Multiteam Membership, Multiteam Systems, Multitasking, & Multidimensional Networks to Monitor & Enable Functional Work Shifts in Astronaut Crews
Understanding and Preventing Crew Member Task Entrainment
Understanding Key Components of Successful Autonomous Space Missions
Dyads and Triads at 140 Million Miles: Factors Affecting Interpersonal Relations in Long-Duration Spaceflight
Personalized Performance Optimization Platform (P-POP)
Human Systems Integration Architecture: On-board System Capability Readiness Assessment
Human System Integration Architecture: Leveraging Lessons Learned from the First ISS Expedition for Long-Duration Exploration Missions
Technological Support for Crew/MCC Communication and Collaboration During Space Exploration Operations
Identifying Risks of Commercial Crew Integration for Spaceflight Operations
Modeling Individual & Team Problem-Solving Skills for the Establishment of Training Metrics, Standards, & Guidelines for Long-Duration Space Missions
Team-106: We need to identify how multiple risks (e.g., BMed, HSIA, Sleep) may increase or buffer Team risk, with potential for integrated, synergistic impact on Team performance and functioning during shifting levels of autonomy for all phases of increasingly earth independent, long duration exploration missions.
Artificial intelligence for tracking micro-behaviors in longitudinal data and predicting their effect on well-being and team performance
Identifying the Risk of Commercialization and Private Astronaut Mission Crew Integration in Spaceflight Operations: PAM Data-Mining
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Private Astronaut Post-Mission Debrief Interviews
Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.
Team and BHP Data Harmonization Update
Assess Glymphatic Changes for Spaceflight
Cognitive Assessment and Prediction to Promote Individualized Capability Augmentation and Reduce Decrement
Quantifying and Predicting Operationally-Relevant Performance in a Long-Duration Spaceflight Analog
Real-Time Estimation of the Effects of a Simulated Long-Duration Exploration Mission on Flight Performance, Workload, and Situation Awareness
Psychomotor Vigilance Test (PVT) on ISS
Psychomotor Vigilance Test (PVT) on ISS (Reaction Self-Test on ISS-12)
The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight
Team and Sleep Preliminary Literature Review
Cognitive Performance and Stress in a Simulated Space Environment
Individualized Stress Detection System
Workload and Scheduling Tools for Long Duration Missions (Research Requirements)
Measuring Transcutaneous Partial Pressure of Carbon Dioxide (PCO2) to Estimate Arterial PCO2 during Spaceflight
Human Factors and Behavioral Performance Exploration Measures Data Harmonization
Human Factors Behavioral Performance Risk Characterization Research for Artemis II
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
The Impact of Chronodisruption on Space Radiation-Induced Gene Signatures
Assessing the impact of caffeine and other dietary factors on crew performance and sleep
Characterizing and mitigating the interactive impacts of fatigue- and altered gravity-related stressors on sensorimotor, behavioral, and operational outcomes (Mehta)
Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.
Validation of model predictions of alertness, performance, and sleepiness
Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station
Evaluation of the validity, acceptability and usability of bio-mathematical models to predict fatigue in an operational environment
LumosTech Smart Sleep Mask for Circadian Realignment in Space and on Earth
Effects of Transdermal Vagal Nerve Stimulation (tVNS) on Cognitive Performance Under Sleep Deprivation Stress
Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight
Countermeasures to Neurobehavioral Deficits from Cumulative Sleep Deprivation During Space Flight: Dose-Response Effects of Recovery Sleep Opportunities
Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space
Development of a Software and User Interface to Support Scenario Modeling of Astronaut Schedules to Aid in the Selection of Fatigue Countermeasures within the Behavioral Health and Performance Dashboard (BHP-DS)
Diet as a sleep/circadian countermeasure (Research Requirements)
Individualized Fatigue Meter for Space Exploration (SBIR Phase II)
Mathematical Modeling of Circadian/Performance Countermeasures
Physiologically-Based Modeling of Sleep-Wake Scheduling and the Effects of Pharmaceuticals (NSBRI Postdoctoral Fellowship)
Software Enabled Therapeutics for Psychiatry, Neurology, and Pain
Spaceprint: Development and Validation of a Tool to Predict, Evaluate, and Mitigate Excessive Workload Effects
Workload and Scheduling Tools for Long Duration Missions (Research Requirements)
Sleep3: Does sleep loss continue on long duration spaceflight or is there adaptation? What is the nature of circadian desynchronization, extended wakefulness and work overload over long duration missions? (Closed)
Sleep-Wake Actigraphy and Light Exposure During Spaceflight
Techwatch for Sleep Monitoring Technologies for Long Duration Spaceflight
Transition Actiwatch Protocol to Medical Operations
Human Health Countermeasures
Concern of Intervertebral Disc Damage upon and immediately after re-exposure to Gravity [inactive]
IVD1: Determine whether post-flight back pain and/or injury are caused by changes to the vertebral body in-flight.
Risk of Intervertebral Disc Damage After Prolonged Spaceflight
Sonographic Astronaut Vertebral Examination
Disc Damage Countermeasure
Disc Herniation Risk Analysis
Risk of Adverse Health Effects Due to Host-Microorganism Interactions
Micro-101: Evaluate the effects of isolation, confinement and weightlessness on changes in the vehicle microbiome, the human microbiome, and microbial virulence.
The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight
Quantitative Risk Assessment Study for Surface Risk
HHC, NASA Flight Experiment Research Contributing to Microbial Risk Modeling
Development of Spaceflight Foods with High Microbial Concentrations
Study of the impact of long-term space travel on the astronaut's microbiome
SWAB E-049 A Comprehensive Characterization of Microorganisms and Allergens in Spacecraft Environment
Free Water Events on Mir and ISS
Data Mining
Fluid Shift Associated Lymphostasis of the Gut Induces Inflammation and Microbial Intolerance (NSBRI-Cromer)
Evaluating the Spaceflight Infectious Disease Risk Potential of Pathogenic and Commensal microorganisms using Caenorhabditis elegans as a Human Surrogate Model for Infection
Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed
Evaluation of Host-Pathogen Interactions During Exposure to Microgravity Analogues -- ASU Grant
Spaceflight-Induced Immune System Dysregulation and Microgravity-Associated Alterations in Microbial Virulence – Infectious Disease Risk for Astronauts
Spaceflight-Induced Changes in Microbial Virulence and Impact to the Host Immune Response
Klebsiella Pneumoniae Mechanisms-Lab
Micro Enhanced Virulence
Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.
HHC, NASA Flight Experiment Research Contributing to Microbial Risk Modeling
Development of Spaceflight Foods with High Microbial Concentrations
Study of the impact of long-term space travel on the astronaut's microbiome
SWAB E-049 A Comprehensive Characterization of Microorganisms and Allergens in Spacecraft Environment
Free Water Events on Mir and ISS
Data Mining
Fluid Shift Associated Lymphostasis of the Gut Induces Inflammation and Microbial Intolerance (NSBRI-Cromer)
Evaluating the Spaceflight Infectious Disease Risk Potential of Pathogenic and Commensal microorganisms using Caenorhabditis elegans as a Human Surrogate Model for Infection
Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed
Retrospective Radiation Effect on Microbiome in irradiated populations
Bacillus spore probiotics: evaluation of survival and efficacy after exposure to deep-space radiation simulating long-duration human exploration missions
Effects of Low Dose Radiation and Radiation Countermeasures on Infection by Spaceflight Analogue Cultured Salmonella using 3-D Biomimetic Human Tissue Models
Micro Enhanced Virulence
Micro-103: Evaluate whether atmospheric composition, such as elevated CO2 levels or mildly hypoxic exploration atmospheres, are a significant contributor to changes in the microbial profile of spaceflight.
Quantitative Risk Assessment Study for Surface Risk
HHC, NASA Flight Experiment Research Contributing to Microbial Risk Modeling
Development of Spaceflight Foods with High Microbial Concentrations
Study of the impact of long-term space travel on the astronaut's microbiome
SWAB E-049 A Comprehensive Characterization of Microorganisms and Allergens in Spacecraft Environment
Free Water Events on Mir and ISS
Data Mining
Evaluating the Spaceflight Infectious Disease Risk Potential of Pathogenic and Commensal microorganisms using Caenorhabditis elegans as a Human Surrogate Model for Infection
Retrospective Carbon Dioxide
Effects of Spaceflight Relevant Carbon Dioxide Levels on Pathogenesis Related Microbial Characteristics
Micro-201: Micro-201: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of adverse health events (infection), during the mission.
Evaluating the Spaceflight Infectious Disease Risk Potential of Pathogenic and Commensal microorganisms using Caenorhabditis elegans as a Human Surrogate Model for Infection
Evaluation of Host-Pathogen Interactions During Exposure to Microgravity Analogues -- ASU Grant
Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed
Spaceflight-Induced Immune System Dysregulation and Microgravity-Associated Alterations in Microbial Virulence – Infectious Disease Risk for Astronauts
Evaluation of Incidence and Severity (Artemis)
Spaceflight-Induced Changes in Microbial Virulence and Impact to the Host Immune Response
Micro Enhanced Virulence
Micro-202: Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/BBB function related to the change in the gut’s microbiome and gut-brain axis (collaboration with HFBP), increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, correlation with inflammation
Delivery of Probiotics in the Space Food System
Efficacy of Antimicrobials on Bacteria Cultured in a Spaceflight Analog
SWAB E-049 A Comprehensive Characterization of Microorganisms and Allergens in Spacecraft Environment
Development of Spaceflight Foods with High Microbial Concentrations
Microbial Risk Assessment and Integration
Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356
The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight
Culture-based Environmental Monitoring of Crop-based Space Food Systems
Maturation Task - MicroHost Standards to OCHMO
Micro Enhanced Virulence
Micro-301: Identify, develop, and implement in-flight microbial monitoring/diagnostic tools for support of research and crew health during Gateway, Lunar, and Mars missions.
Culture-based Environmental Monitoring of Crop-based Space Food Systems
Quantitative Microbial Risk Assessment: Exploring the Microbiome at the International Space Station to Develop Food Production Systems
Next Generation Microbiology Requirements
Free Water Events on Mir and ISS
Baseline Microbial Assessment of Fresh Produce
Produce Safety Methods
Microbial Database
Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.
MicroHost Countermeasure Validation
Delivery of Probiotics in the Space Food System
Efficacy of Antimicrobials on Bacteria Cultured in a Spaceflight Analog
SWAB E-049 A Comprehensive Characterization of Microorganisms and Allergens in Spacecraft Environment
Development of Spaceflight Foods with High Microbial Concentrations
Microbial Risk Assessment and Integration
Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356
Maturation Task - Micro CM to SCLT/HMTA
Risk of Adverse Health Event Due to Altered Immune Response
IM-106: Characterize the effect of the stressors associated with spaceflight (stress, microgravity, radiation, altered nutrition, circadian misalignment, hypoxia, etc.) on human immunity, determine clinical relevance and biomarkers to enable monitoring of astronauts.
Functional immune alterations, latent Herpesvirus reactivation, physiological stress and clinical incidence onboard the International Space Station
Functional Immune -DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune
Functional Immune -The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune
Monitoring the Cellular Immunity by in vitro Delayed Type Hypersensitivity Assay on ISS
Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.
Spaceflight-Induced Immune System Dysregulation and Microgravity-Associated Alterations in Microbial Virulence – Infectious Disease Risk for Astronauts
The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract
Effect of Space Radiation on Innate Immune System Homeostasis Drives Immune and Endothelial Cell Dysfunction and Neurodegeneration
Effects of space flights on the proteome of astronauts' plasma (Rithidech) functional immune
Awakening endogenous retroviruses with the space environment
SPE Immune
Dry Saliva Validation (Lab)
Monitoring of Deep Space Physiology via Dry Saliva and Dry Blood Sampling during Artemis Missions
Maturation Task - Immune Standards to OCHMO
IM-201: Based on immune dysfunction biomarkers identified in gap IM-106, identify, develop, and implement in-flight immune function monitoring tools for support of research during Gateway, Lunar, and Mars missions.
MinION Viral Detection
Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station
Monitoring the Cellular Immunity by in vitro Delayed Type Hypersensitivity Assay on ISS
IM-301: Identify appropriate ground-based analogs to spaceflight-induced immune dysfunction to enable ground validation of preventive/mitigative countermeasures, and derive mechanistic insights.
Conditions of Toll like receptors system of the human innate immunity cells during long-term isolations
Pilot Assessment of Stress and Latent Herpesvirus Reactivation at Palmer, Antarctica - Platform for Validation of Immune Countermeasures?
Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station
HERA In-flight Immune
IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures
The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight
Nutritional Status Assessment: SMO-016E
Space Biochemistry Profile
Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station
Immune Countermeasures Validation - Flight
IM-402: Test, optimize and validate pharmacological preventive/mitigative countermeasures.
Varicella Zoster virus shedding after antiviral drug (Valacyclovir) treatment in Antarctic expeditioners
The impact of simulated microgravity on the anti-tumor properties of human NK-cells and ?d-T cells in vivo: IL-2 and zoledronic acid therapy as a potential countermeasure
Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station
Immune Countermeasures Validation - Flight
IM-403: Test, optimize and validate stress reduction techniques as preventive and mitigative immune dysfunction countermeasures.
Immune Countermeasures Validation - Flight
Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station
Exercise training as countermeasure for anti-tumor immune dysregulation due to isolation and confinement stress
IM-501: Test the finalized, integrated, multi-component immune countermeasure in flight.
Immune Countermeasures Validation - Flight
Validation of Multisystem Countermeasures Protocol for Spaceflight during Antarctica Winterover @ Palmer Station
Maturation Task - Immune CM to SCLT/HMTA
IM7: It is necessary to correlate the observed effects of spaceflight-associated immune system dysregulation with known terrestrial clinical conditions.
Clinical Immunology Study - European Collaboration
Immune Clinical Correlations
Monitoring the Cellular Immunity by in vitro Delayed Type Hypersensitivity Assay on ISS
The impact of long duration spaceflight on the function of B-cells and biomarkers of inflammation (Spielmann)
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
Exercise training as countermeasure for anti-tumor immune dysregulation due to isolation and confinement stress
Risk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after G transitions.
Sensorimotor Predictors of Postlanding Functional Task Performance (Wood)
Recovery of Functional Performance Following Long Duration Space Flight (Wood)
Functional Task Tests in Partial Gravity during Parabolic Flight (Clement)
Validation of Fitness for Duty Standards Using Pre- and Post-Flight Capsule Egress and Suited Functional Performance Tasks in Simulated Reduced Gravity (Norcross)
SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest (Bershad)
Development of Sensorimotor Fitness for Duty Standards Using Ground Analogs
Development of Countermeasures to Aid Functional Egress from the Crew Exploration Vehicle Following Long-Duration Spaceflight (Mulavara)
Physiological Factors Contributing to Postflight Changes in Functional Performance (Bloomberg)
Galvanic Vestibular Stimulation (GVS) as an Analogue of Post-flight Sensorimotor Dysfunction (Moore)
Promoting Sensorimotor Response Generalizability: A Countermeasure to Mitigate Locomotor Dysfunction After Long-Duration Spaceflight (Bloomberg)
Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)
Performance Data Mining: Correlation Between Previous Performance Data with Clinical Observations. (Reschke)
Recovery Data Mining: Relationship Between In-Flight Exercise and Postflight Sensorimotor Performance. (Reschke)
Sensorimotor Assessment and Rehabilitation Apparatus: Procedures and Equipment (Schubert)
Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)
Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara)
Spatial Reorientation of Sensorimotor Balance Control in Altered Gravity (Paloski)
Vestibular-Evoked Myogenic Potentials in Microgravity
Sensorimotor Fitness for Duty Assessment - ISS (TBD)
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Maturation Task - Sensorimotor Standards to OCHMO
Gender Difference and the Reversibility of the Structural Brain Changes of Spaceflight Correlated with Cognitive/Behavioral Performance
Lunar Landing & Egress-Artemis
SM-102: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on manual control (fine motor control) after G transitions.
Sensorimotor Fitness for Duty Assessment - ISS (TBD)
Physiological Factors Contributing to Postflight Changes in Functional Performance (Bloomberg)
Galvanic Vestibular Stimulation (GVS) as an Analogue of Post-flight Sensorimotor Dysfunction (Moore)
Sensorimotor adaptation following exposure to ambiguous inertial motion cues (Wood)
Robust Human-System Interface Design for Spaceflight-Induced Environments (Interface Design-Stone, Completed)
Sensorimotor Displays and Controls to Enhance the Safety of Human/Machine Cooperation During Lunar Landing (Lander D&C-Young, Completed)
Assessment of Operator Proficiency Following Long-Duration Spaceflight (Moore)
Effect of Sensorimotor Adaptation Following Long-Duration Spaceflight on Perception and Control of Vehicular Motion (Wood)
Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)
Performance Data Mining: Correlation Between Previous Performance Data with Clinical Observations. (Reschke)
Advanced Displays for Efficient Training and Operation of Robotic Systems (Robotic Systems-Oman, Completed)
Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)
Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara)
Data mining activities for Sensorimotor Discipline (Reschke)
(ZAG/Otolith) Ambiguous Tilt and Translation Motion Cues After Spaceflight/ Otolith Assessment During Postflight Re-adaptation (Wood)
Effects of Long-duration Microgravity on Fine Motor Control Skills
Vestibular-Evoked Myogenic Potentials in Microgravity
Manual Crew Override of Vehicle Landings following G-transitions - ISS (Wood)
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Effects of Altered-Gravity on Perception and Bi-manual Coordination: Impacts on Functional Performance (Diaz Artiles)
Operational Performance Effects and Neurophysiology in Partial Gravity (OPEN-PG, Strangman)
Gender Difference and the Reversibility of the Structural Brain Changes of Spaceflight Correlated with Cognitive/Behavioral Performance
SM-103: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions.
Straight Ahead in Microgravity (Clement)
Assessment of Otolith Function and Asymmetry as a Corollary to Critical Sensorimotor Performance in Missions of Various Durations (Shelhamer)
Neuro-Vestibular Examination During and After Spaceflight (Clement)
Investigation of Partial-g Effects on Ocular Alignment (Shelhamer)
Development of Sensorimotor Fitness for Duty Standards Using Ground Analogs
Sensorimotor Fitness for Duty Assessment - ISS (TBD)
Physiological Factors Contributing to Postflight Changes in Functional Performance (Bloomberg)
Galvanic Vestibular Stimulation (GVS) as an Analogue of Post-flight Sensorimotor Dysfunction (Moore)
Head-Eye Coordination during Simulated Orbiter Landings (Moore)
Sensorimotor adaptation following exposure to ambiguous inertial motion cues (Wood)
Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)
Performance Data Mining: Correlation Between Previous Performance Data with Clinical Observations. (Reschke)
Pre-flight Training of Autonomic Responses for Mitigating the Effects of Spatial Disorientation During Spaceflight (Cowings)
Sensorimotor Assessment and Rehabilitation Apparatus: Procedures and Equipment (Schubert)
Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)
Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara)
Neurovestibular Aspects of Short-radius Artificial Gravity: Toward Comprehensive Counter Measure (Young)
(ZAG/Otolith) Ambiguous Tilt and Translation Motion Cues After Spaceflight/ Otolith Assessment During Postflight Re-adaptation (Wood)
Vestibular-Evoked Myogenic Potentials in Microgravity
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Gender Difference and the Reversibility of the Structural Brain Changes of Spaceflight Correlated with Cognitive/Behavioral Performance
Optimizing the combination of intranasal scopolamine and sensory augmentation to mitigate G-transition induced motion sickness and enhance sensorimotor performance (Wood)
SM-104: Evaluate how weightlessness-induced changes in sensorimotor/vestibular function relate to and/or interact with changes in other brain functions (sleep, cognition, attention).
Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, and Neural Bases (NeuroMapping-Flight-Seidler)
Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Recovery of Functional Performance Following Long Duration Space Flight (Wood)
Operational Performance Effects and Neurophysiology in Partial Gravity (OPEN-PG, Strangman)
Sensorimotor Predictors of Postlanding Functional Task Performance (Wood)
Bed Rest Combined with 0.5% CO2 as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases
Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler)
Vestibular-Evoked Myogenic Potentials in Microgravity
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes during Long-Duration Low-Earth Orbit Missions
Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)
Developing Personalized Countermeasures for Sensorimotor Adaptability: A Bedrest Study (Mulavara)
Combined Behavioral Stressor Data Integration and POL/PEL Standard Update
Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining
Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
Effects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.
Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
NHP CNS Radiation/Performance Data Mining
Future research (NSCOR) -- potential topics include RBEs, Glial cell response, stress response, cross-species homology, animal mood/social/cognition, sleep/stress/cognition, neural plasticity, dose rate effect for multiple measures
Determine & Validate Combined Behavioral Stressor relevant operational measures for integrated POLs and identify Research Measures for EM missions
Combined Behavioral Stressor Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and combinatorial effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
CBS Operational Performance Measures
Integrated Combined Behavioral Stressor POL/PEL Review and Standard Update
Research Review: Neurobehavioral Biomarkers Performance/Pathway
Research Review: NHP Model Brain Performance Pathways
CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation
CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Long-Term Brain Structural and Functional Consequences of Spaceflight
SM Occ Health Survey
Gender Difference and the Reversibility of the Structural Brain Changes of Spaceflight Correlated with Cognitive/Behavioral Performance
Development of Sensorimotor Fitness for Duty Standards Using Ground Analogs
Characterizing and mitigating the interactive impacts of fatigue- and altered gravity-related stressors on sensorimotor, behavioral, and operational outcomes (Mehta)
SM-201: Develop and test postural control and locomotion countermeasures, including human factors aids.
A simple and compact countermeasure for maintenance and enhancement of neuromuscular control during spaceflight (Valero-Cuevas)
Resveratrol and electrical muscle stimulation as countermeasures to preserve sensorimotor function during a 60-day head-down bedrest protocol (Rutkove)
Orion Crew Performance and Safety Immediately Following Postflight Water Landings: Emergency Egress (Peters)
DEFERRED: Development of an integrated sensorimotor countermeasure suite for spaceflight operations
Development of Countermeasures to Enhance Sensorimotor Adaptation (Bloomberg)
Countermeasures for Mitigation of Sensorimotor Decrements Following Head-Down Bed Rest (Macaulay)
Exploration Exercise Treadmill Requirements
SM-202: Develop and test manual control countermeasures, such as vibrotactile assistance vest, and other human factors aids.
Orion Crew Performance and Safety Immediately Following Postflight Water Landings: Emergency Egress (Peters)
Detecting Pilot Spatial Disorientation to Trigger Active Countermeasures During Lunar Landing (Clark)
Sensorimotor adaptation following exposure to ambiguous inertial motion cues (Wood)
(ZAG/Otolith) Ambiguous Tilt and Translation Motion Cues After Spaceflight/ Otolith Assessment During Postflight Re-adaptation (Wood)
A non-pharmacological countermeasure suite for motion sickness induced by post-flight water landings (T. Clark)
Maturation Task - Sensorimotor Lunar Manual Control CM to HMTA
Manual Crew Override of Vehicle Landings following G-transitions - ISS (Wood)
Vibrotactile Feedback as a Countermeasure for Spatial Disorientation during a Stabilization Task in a Spaceflight Analog Condition
MATRIKS: Multi-Environment Virtual Training for Long Duration Exploration Missions
Mars Adaptive Training Integrative Knowledge System (MATRIKS) to Improve Operational Performance and Its Neural Basis for Spaceflight
SM-203: Develop and test SMS countermeasures.
Non-pharmaceutical motion sickness mitigation (Wood)
Orion Crew Performance and Safety Immediately Following Postflight Water Landings: Emergency Egress (Peters)
Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting from Altered Gravity Levels (Young)
Ground validation of self-administered incremental rehabilitation tool to mitigate motion sickness and enhance sensorimotor recovery (Schubert)
A non-pharmacological countermeasure suite for motion sickness induced by post-flight water landings (T. Clark)
Vibrotactile Feedback as a Countermeasure for Spatial Disorientation during a Stabilization Task in a Spaceflight Analog Condition
SM-204: Develop and test post-planetary-landing self-administered testing and rehab tool.
Ground validation of self-administered incremental rehabilitation tool to mitigate motion sickness and enhance sensorimotor recovery (Schubert)
Sensory Augmentation to Enhance Recovery-Centrifuge
SM-301: Test the finalized combined CM Suite in flight.
Maturation Task - Sensorimotor CM to SCLT/HMTA
Sensorimotor CM Validation-LEO
Self Administered Post-Flight Rehab Tool – ISS (TBD)
Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas (NRA)
Behavioral Medicine Integrated Risk Review & Trade Study
CBS Biomarker and Countermeasure (CM) Flight Update/Validation Based on Biomarkers and Operationally-Relevant Performance Measures
Combined Behavioral Stressor CM2: Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on Risk Areas
Integrative Risk Data Mining: Individual Sensitivities and Countermeasures
Optimizing the combination of intranasal scopolamine and sensory augmentation to mitigate G-transition induced motion sickness and enhance sensorimotor performance (Wood)
Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
Fracture 1: We don't understand how the space flight environment affects bone fracture healing in-flight.
Fracture Healing in Haversian Bone under Conditions of Simulated Microgravity
Extent, Causes, and Countermeasures of Impaired Fracture Healing in Hypogravity
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
A Scanning Confocal Acoustic Diagnostic System for Non-Invasively Assessing Bone Quality
Whole Joint Health: Investigating Modeled Spaceflight Changes in Mice (Postdoctoral Fellowship)
Fracture 2: We need to characterize the loads applied to bone for standard in-mission activities.
Bone Turnover Model: Initial Implementation
Fracture Healing in Haversian Bone under Conditions of Simulated Microgravity
Whole Joint Health: Investigating Modeled Spaceflight Changes in Mice (Postdoctoral Fellowship)
Fracture 3: We need a validated method to estimate the the risk of fracture by evaluating the ratio of applied loads to bone fracture loads for expected mechanically-loaded activities during a mission.
Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone
Vertebral Compression Fracture Assessment
Bone Turnover Model: Initial Implementation
Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies
Digital Astronaut: Bone Remodeling Model
Vertebral strength and fracture risk following long duration spaceflight
Astronaut Bone Medical Standards Derived from Finite Element (FE) Modeling of QCT Scans from Population Studies and Astronauts (Phase II)
Bone-101: Characterize skeletal changes on bone mass (Bone Density) and bone structure (Bone Quality) of astronauts.
Developing a new bone medical standard for long-duration astronauts based on bone strength estimated by Finite Element [FE] Modeling
Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies
Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone
Astronaut Bone Medical Standards Derived from Finite Element (FE) Modeling of QCT Scans from Population Studies and Astronauts (Phase II)
Maintaining Musculoskeletal Health in the Lunar Environment
Space Biochemistry Profile
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)
Effects of Acute and Protracted Galactic Cosmic Radiation on Bone Strength.
Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight
Data Mining for Bone Research and Clinical Advisory Panel (RCAP)
Nutritional Status Assessment: SMO-016E
An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions
Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms
Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects
Bone Turnover Model: Initial Implementation
Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity
Pilot Studies of Radiation Damage in Organ Tissues of Mice
Simulated space radiation and weightlessness: vascular-bone coupling mechanisms to preserve skeletal health
Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight
Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)
Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)
Increasing the Efficiency of Exercise Countermeasures for Bone Loss
Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading Induced Osteoporosis
Bone Recovery Potential After Bisphosphonate and PTH Treatment of Disuse Osteoporosis
Digital Astronaut: Bone Remodeling Model
Effect of Unloading on the Structure and Mechanics of Rotator Cuff Tendon-to-Bone Insertion
Assessment of Structural and Functional Knee Joint Degradation During Modeled Spaceflight
Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery (Bloomfield)
Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)
Spinal Structure and Function after 90 Days Long-Duration Simulated Space Flight and Recovery
Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)
Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Magnetic Resonance Imaging (MRI) to assess Changes to Trabecular Microarchitecture of the Hip
EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Gordon)
Trabecular Microarchitecture - ISS
CSA - CIPHER TBone2
Bone-102: Characterize bone turnover and other biomolecular markers of skeletal health.
Space Biochemistry Profile
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)
Effects of Acute and Protracted Galactic Cosmic Radiation on Bone Strength.
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight
Data Mining for Bone Research and Clinical Advisory Panel (RCAP)
Nutritional Status Assessment: SMO-016E
An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions
Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms
Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects
Bone Turnover Model: Initial Implementation
Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity
Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure
Space Radiation and Bone Loss: Lunar Outpost Mission Critical Scenarios and Countermeasures
Pilot Studies of Radiation Damage in Organ Tissues of Mice
Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)
Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)
Increasing the Efficiency of Exercise Countermeasures for Bone Loss
Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading Induced Osteoporosis
Bone Recovery Potential After Bisphosphonate and PTH Treatment of Disuse Osteoporosis
Digital Astronaut: Bone Remodeling Model
Effect of Unloading on the Structure and Mechanics of Rotator Cuff Tendon-to-Bone Insertion
Assessment of Structural and Functional Knee Joint Degradation During Modeled Spaceflight
Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery (Bloomfield)
Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)
Spinal Structure and Function after 90 Days Long-Duration Simulated Space Flight and Recovery
Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)
Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Maturation Task - Input to Bone Standards to OCHMO
EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Gordon)
CSA - CIPHER TBone2
Bone-201: Identify/develop/apply tools (e.g., computational modeling or alternative) to inform the estimation bone strength and probability of overloading bones and fracture assessment.
Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)
Space Biochemistry Profile
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Effects of Acute and Protracted Galactic Cosmic Radiation on Bone Strength.
Data Mining for Bone Research and Clinical Advisory Panel (RCAP)
Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone
Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight
Nutritional Status Assessment: SMO-016E
An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions
Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms
Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects
Bone Turnover Model: Initial Implementation
Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity
Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure
Space Radiation and Bone Loss: Lunar Outpost Mission Critical Scenarios and Countermeasures
Pilot Studies of Radiation Damage in Organ Tissues of Mice
Simulated space radiation and weightlessness: vascular-bone coupling mechanisms to preserve skeletal health
Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight
Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)
Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)
Increasing the Efficiency of Exercise Countermeasures for Bone Loss
Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading Induced Osteoporosis
Bone Recovery Potential After Bisphosphonate and PTH Treatment of Disuse Osteoporosis
Digital Astronaut: Bone Remodeling Model
Effect of Unloading on the Structure and Mechanics of Rotator Cuff Tendon-to-Bone Insertion
Assessment of Structural and Functional Knee Joint Degradation During Modeled Spaceflight
Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery (Bloomfield)
Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)
Spinal Structure and Function after 90 Days Long-Duration Simulated Space Flight and Recovery
Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)
Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing
Bone-301: Identify, develop, and implement monitoring tools for bone health during spaceflight.
Space Biochemistry Profile
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)
EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Gordon)
Printed Electrochemical Sensor Strip for Quantifying Bone Density Loss in Microgravity (Koehne)
In-flight Bone Monitoring
Flywheel/control Bedrest (placeholder)
Bone-401: Identify and test preventative and mitigating countermeasures for changes induced by spaceflight.
EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Gordon)
Space Biochemistry Profile
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)
Effects of Acute and Protracted Galactic Cosmic Radiation on Bone Strength.
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Ground Testing Bone CMs
Flywheel/control Bedrest (placeholder)
Bone-402: Validate countermeasures for maintaining preflight bone standard.
EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Gordon)
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Maturation Task - Bone CM to HMTA
Bone Validate CMs - CLD
Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
CV-101: Determine whether long-duration weightlessness and/or reduced gravity induces cardiovascular structural and functional adaptations that contribute to an increased risk of a cardiovascular event or and disease.
Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance (Stenger)
Fluid Distribution before, during and after Prolonged Space Flight (Hargens)
Microgravity Associated Compartmental Equilibration (Dulchavsky)
VIIP Simulations of CSF, Hemodynamics and Ocular Risk (Ethier)
Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE]
Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT]
Bracelet Investigation (Brazlet Dulchavsky, Completed)
Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)
Gravitational dose and multi-system physiologic response
Recovery of Functional Performance Following Long Duration Space Flight (Wood)
Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine)
Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas)
Proteomic Profiling of Human Heart Tissue Exposed to Microgravity (Proteomic Heart-Bowles, Completed)
The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)
Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)
Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE]
Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Lee)
Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)
Cardiovascular Disease Data Mining Phase II with Cooper Clinic
Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea)
The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)
Biomarker Assessment for Identifying Heightened Risk for Cardiovascular Complications During Long-Duration Space Missions [IMAGING AND OMICS - CV RISK/LINDNER]
Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures
Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight
Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)
Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)
Characterization of Jugular Venous Blood Flow during Acute Fluid Shifts (Marshall-Goebel)
Coronary Anatomy and Physiology During 1 Year in Space - ISS (Levine)
Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)
Venous Thromboembolism Characterization - ISS
Determining the Dose Response Profile of the Headward Fluid Shift during Varying Gravity Levels (Lee)
Artificial Gravity Exposure Effects on Cardiovascularly Deconditioned Women's and Men's Orthostatic Intolerance Limit (Ames AG EPSCoR-Evans, Completed)
Determination of the magnitude and time course of cardiovascular alterations during a simulated extended stay lunar mission
Risk Quantification Pilot with IMM for HSRB
Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)
Effect of Sex on Orthostatic Intolerance and Cardiovascular Responses during Lunar Descent and Ascent
Maturation Task - CV Responses to Various HLS G Levels and Countermeasure Recommendations
TRRaC Radiation Induced Carcinogenesis Biomarkers
Maturation Task - Inputs to Cardiovascular Standards to OCHMO
CV-102: Determine whether space radiation induces cardiovascular structural and functional adaptations and/or oxidative stress and damage (OSaD)/inflammation that contribute to an increased risk of a cardiovascular event or and disease.
Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing
Imaging and Serum Biomarkers to Predict and Identify Early Cardiac Injury from Radiation Exposure
Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
Determination of risk for and occurrence of heart disease from space radiation
Space Radiation Risk Assessment Project
Center for Research on Cardiac and Vascular Effects of Space Radiation
Space Radiation Risk Assessment Project-Cucinotta
Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation
Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability
Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice
Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration
Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models
Degenerative Cardiovascular Disease Risks Due to Single HZE or Mixed Ion Radiation
Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome
Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits (Mao)
Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.
Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation
Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks
Tissue Sharing Project-Effects of space radiation on the cardiac mitochondrial stress response
A determination of bioactive proteins secreted by the human vasculature in response to low dose space radiation
Predictive Biomarkers for Space Radiation Induced Cancer and Cardiovascular Injury Risk Assessment
Telomeres and the One Year Mission Project
Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.
Early Markers of Space-Radiation Induced Human Cataractogenesis
Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations
Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight
Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis
Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status
Mechanisms of Ocular Cataracts
The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease
A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation
Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation
Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens
Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis
Long-Term Effect of Space Radiation on Cardiomyocyte Turnover
Low Dose Radiation Cataract
Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening
Million Worker and Veteran Study
GCR Simulation Dose Rate Studies
Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active)
Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)
Animal radiation study (Radiation Pilot-Westby, Completed)
Coronary Anatomy and Physiology During 1 Year in Space - ISS (Levine)
Effect of Space Radiation on Innate Immune System Homeostasis Drives Immune and Endothelial Cell Dysfunction and Neurodegeneration
Integration of In-Silico and In-Vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction.
Radiation resistance conferred by small proline rich repeat proteins (SPRRs).
Cardiovascular Countermeasure Drug Screening for Radiation Exposure
TRRaC Radiation Induced Carcinogenesis Biomarkers
CV-103: Determine whether the combined effects of space radiation and altered gravity induce additive or synergistic effects on the cardiovascular system that contribute to an increased risk of a cardiovascular event or and disease.
Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Lee)
Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders
Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease, and the effectiveness of a countermeasure
Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.
Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms
Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats
Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135
Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes
Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)
Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)
2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)
Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)
Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)
Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow)
Effect of Space Radiation on Innate Immune System Homeostasis Drives Immune and Endothelial Cell Dysfunction and Neurodegeneration
TRRaC Radiation Induced Carcinogenesis Biomarkers
Lunar Landing & Egress-Artemis
Multirisk Art VII-Long Lunar
CV-202: Identify, develop, and test candidate countermeasures in a spaceflight analog, including monitoring strategies, that prevent or mitigate spaceflight- and/or radiation-induced cardiovascular structural and functional adaptations that contribute to an increased risk of a cardiovascular event and/or disease.
Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing
2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)
Center for Research on Cardiac and Vascular Effects of Space Radiation
Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)
Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)
Cardiovascular Countermeasure Drug Screening for Radiation Exposure
Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease, and the effectiveness of a countermeasure
CV-203: Evaluate candidate countermeasures in astronauts, including monitoring strategies, that prevent or mitigate spaceflight- and/or radiation-induced cardiovascular structural and functional adaptations in a spaceflight environment that contribute to an increased risk of a cardiovascular event and/or disease.
CVD Integrated Flight Countermeasure Study on ISS
CV-301: Validate an integrated countermeasure suite, including monitoring strategies, that prevent or mitigate the spaceflight and/or radiation-induced cardiovascular structural and functional adaptations in a spaceflight environment that contribute to an increased risk of a cardiovascular event and/or disease.
CVD Integrated Flight Countermeasures Validation Study in Artemis Missions
Maturation Task - Cardiovascular CM to SCLT/HMTA
3D scanning system to assess gravity-dependent body shape changes
CV4: Is 1/6-g exposure protective of 1-g orthostatic tolerance?
Lunar Analog Bed Rest Development (N/A, Closed)
Lunar analog pilot study (LAPS-Cromwell, Closed)
Risk of Decompression Sickness [inactive]
DCS1: We do not know the acceptable DCS risk with respect to the work efficiency index (WEI) for exploration scenarios.
DCS2: We do not know the contribution of specific DCS risk factors to the development of DCS in the Space Flight Exploration Environment.
Mechanisms of Musculoskeletal-Induced Nucleation in Altitude Decompressions Stress II
Improved Bubble Detection for EVA
DCS3: We do not know the mission related factors that contribute to DCS risk.
Develop and test EVA Workload Simulator
Feasibility Study of EVA Workload Simulator for Use in 1-g Environment
Mechanisms of Musculoskeletal-Induced Nucleation in Altitude Decompressions Stress II
DCS4: We do not know to what extent physiological and environmental factors can be incorporated and validated in a model of DCS for micro and reduced gravity.
Develop and Evaluate Treatment Model for DCS
DCS5: We do not know what validated procedures will adequately prevent DCS.
DCS6: We do not know what new developments related to DCS will come from other investigators.
DCS7: We have not validated procedures to adequately treat DCS in the spaceflight environment should it occur.
Potential Subclinical Neurologic Changes in Astronauts due to Repeated Hypobaric Exposures
Data Mining and Development of Spaceflight DCS Treatment Model
Risk of Injury and Compromised Performance Due to EVA Operations
EVA-101: Characterize EVA preparedness shortly post-landing on a planetary surface.
Validation of Fitness for Duty Standards Using Pre- and Post-Flight Capsule Egress and Suited Functional Performance Tasks in Simulated Reduced Gravity (Norcross)
EVA Health and Human Performance Benchmarking Study
Identification of Aerobic Fitness Standards For Exploration Mission Tasks
Identification of Muscle Fitness Standards For Exploration Mission Tasks
DEFERRED: Quantifying and Preventing EVA Injury in Exploration Environments (Hoffman)
Metabolic Evaluations on POGO, ARGOS
Effects of Terrain on Performance
Constellation Program (CxP) EVA Systems Test 3 - Effect of Center of Gravity on Metabolic Costs and Biomechanics of Ambulation in a Planetary Suit
Test and Evaluation of Liquid Cooling Garments
Advanced EVA Biomedical Energetics Performance and Space Suit Assessment
Metabolic Cost of Experimental Exercise
ACES Evaporative Cooling Evaluation
Haughton Mars Project (HMP) 10 km Radial Distance Walkback Test
Optimization of Astronaut Decompression Sickness Prevention Protocols Using Probabilistic Gas and Bubble Dynamics Models
ARGOS & Infrastructure Update
Metabolic Assessment of Suited Mobility using Functional Tasks
Spacesuit Trauma Countermeasure System for Intravehicular and Extravehicular Activities
Human Factors Evaluation of Small Pressurized Rover Sleep Stations & Exercise Device
Mechanisms of Injury associated with fingertip-pressure in EVA gloves
EVA Suit Exposure Tracking System Development & Surveillance
OCT High Performance EVA Glove (HPEG) Project Support
Physical and Cognitive Subject Characterization in Support of Aerobic Fitness and Muscle Strength Fitness for Duty Standards (Strock)
Maturation Task - EVA Fitness for Duty Standards to OCHMO
Lunar Landing & Egress-Artemis
EVA-102: Characterize surface EVA performance during exploration missions in partial gravity environments
Characterization of Physical and Cognitive Workloads Associated with Frequent Exploration Surface Extravehicular Activities and Operations
Multirisk Art VII-Long Lunar
EVA Performance in Artemis-Data Mining
Physical and Cognitive Subject Characterization in Support of Aerobic Fitness and Muscle Strength Fitness for Duty Standards (Strock)
EVA-201: Characterize impacts of variable atmospheric conditions on human health and performance, including exploration atmospheres, variable pressure suits, and alternate prebreathe strategies.
EVA Health and Human Performance Benchmarking Study
DEFERRED: Quantifying and Preventing EVA Injury in Exploration Environments (Hoffman)
Center of Gravity (CG) Evaluations on POGO, NBL, NEEMO, Parabolic Flight
Suit Mass Evaluations on POGO, NBL, NEEMO, Parabolic Flight
Suit Pressure Evaluations on POGO, NBL, NEEMO, Parabolic Flight
Joint Characteristics/Mobility Evaluations on POGO, NBL, NEEMO, Parabolic Flight
Suit Parameters/Human Performance Predictive Tool
Constellation Program (CxP) EVA Systems Test 3 - Effect of Center of Gravity on Metabolic Costs and Biomechanics of Ambulation in a Planetary Suit
Integrated Parabolic Flight Test: Effects of Center of Gravity & Mass on the Biomechanics, Kinematics, & Operator Compensation of Exploration Tasks in Lunar Gravity
EVA CG Assessments; EVA Task Efficiency Index (TEI) assessment; EVA Work Efficiency Index (WEI) assessment
EVA CG Assessments; EVA Optimal Suit Weight; EVA Work Efficiency Index (WEI) assessment; Exploration Scenario 2
CG Assessment (during Exploration Scenario activities); Optimal Weight of Suit Assessment (during Exploration Scenario activities); EVA CG Assessments; EVA CG & Optimal Suit Weight Assessments; EVA Optimal Suit Weight; EVA Work Efficiency Index (WEI) assessment
EVA CG Assessments; EVA CG & Optimal Suit Weight Assessments; EVA Optimal Suit Weight
Effect of Center of Gravity and Suit Weight on Human Performance in Partial Gravity
EVA CG Assessments; EVA Optimal Suit Weight; Task Efficiency; EVA Work Efficiency Index (WEI) assessment
Spacesuit Trauma Countermeasure System for Intravehicular and Extravehicular Activities
Human Factors Evaluation of Small Pressurized Rover Sleep Stations & Exercise Device
Mechanisms of Injury associated with fingertip-pressure in EVA gloves
EVA Suit Exposure Tracking System Development & Surveillance
OCT High Performance EVA Glove (HPEG) Project Support
Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study
Contingency Inspired Carbon Dioxide Standards for Suited Operations (Nusbaum)
CO2 Sensitivity - ISS (Nusbaum)
EVA Performance at Higher Pressure
Maturation Task - EVA Contingency CO2 Standard to OCHMO
3D scanning system to assess gravity-dependent body shape changes
EVA-301: Identify and test countermeasures related to spatial disorientation and motion sickness to enable early EVA’s post g-transition.
Optimizing the combination of intranasal scopolamine and sensory augmentation to mitigate G-transition induced motion sickness and enhance sensorimotor performance (Wood)
Self Administered Post-Flight Rehab Tool – ISS (TBD)
EVA-302: Identify and test countermeasures to any physiological decrements associated with increased planetary EVA cadence (ie, exercise and nutrition)
Work Hardening
EVA-303: Identify and test countermeasures related to exposure to variable atmospheric conditions
Aerospace Estimation Tool for Hypobaric Exposure Risk
Maturation Task - EVA Aerospace Estimation Tool for Hypobaric Exposure Risk to HMTA
EVA-401: Validate integrated EVA performance countermeasures related to optimizing physiological performance and minimizing DCS risk
EVA Integrated Countermeasures-Artemis
Maturation Task - EVA Countermeasures to HMTA
EVA14: What other EVA-related risks, developments and technologies exist that may affect EVA research?
3D scanning system to assess gravity-dependent body shape changes
Risk of Mission Performance Decrements and Adverse Health Outcomes Resulting from Reduced Cardiorespiratory and Musculoskeletal Fitness
MA-101: Characterize the effects of the spaceflight environment, including reduced gravity (i.e., weightlessness, partial gravity), countermeasures, and individual variability, on physiological and functional measures of muscular and cardio-respiratory fitness and performance.
Alterations in Energy Metabolism Pathways in Skeletal Muscle in Relation to Microgravity Analog and Space Radiation
Assessment of the Time Courses of Leg Muscle Strength and Performance Losses During Prolonged Spaceflight using MARES (Laughlin)
Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device (Ferrigno)
Development of a Muscle Adaptation in Space-flight Simulator ("MASS")
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Hypovolemia as A Model Of Space Flight: Cardiovascular Exercise Effects and Countermeasures
In-flight Demonstration of Portable Load Monitoring Devices-Phase I: XSENS ForceShoe™
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Maximal Oxygen Uptake (VO2max) and Submaximal Estimates of VO2max Before, During and After Long Duration International Space Station Missions
Modulation of Muscle Function by Lower Limb Loading during Space Flight
Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Redox Modulation of Skeletal Muscle Function in Microgravity
Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests
Retrospective analysis of inflight exercise loading and health outcomes
Temporal changes in astronauts muscle and cardiorespiratory physiology pre, during, and post spaceflight (Rivas)
Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)
MA-102: Determine the relationship between physiological and functional measures of muscular and cardio-respiratory fitness or performance and mission-specific task performance and crew health outcomes.
EVA Health and Human Performance Benchmarking Study
Characterization of Physical and Cognitive Workloads Associated with Frequent Exploration Surface Extravehicular Activities and Operations
Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)
Identification of Aerobic Fitness Standards For Exploration Mission Tasks
Identification of Muscle Fitness Standards For Exploration Mission Tasks
Multirisk Art VII-Long Lunar
Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures
Physical and Cognitive Subject Characterization in Support of Aerobic Fitness and Muscle Strength Fitness for Duty Standards (Strock)
Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests
Standardized “Pre-flight” Exercise Tests to Predict Performance during Extravehicular Activities in a Lunar Environment
Space Suit Simulator (S3) for Partial Gravity EVA Experimentation and Testing
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Development of a Submaximal Cycling Protocol to Identify the Ventilatory Threshold in Astronauts: Application to Monitor Changes in Endurance Capacity in Response to Long-Duration Spaceflight Missions
Maximal Oxygen Uptake (VO2max) and Submaximal Estimates of VO2max Before, During and After Long Duration International Space Station Missions
Identification of skeletal muscle performance thresholds for extended duration functional task performance.
EVA Performance at Higher Pressure
MA-201: Determine the required exercise countermeasure or countermeasures (i.e., modality or modalities, prescription, monitoring) to protect mission-specific task performance and crew health outcomes.
Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity Independent Training Device
Evaluation of Advanced Exercise Concepts Devices for Down-Select Decision (Perusek)
Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device
Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device (Ferrigno)
Controlled Resistance Exercise Device
Compact, Controlled Force Crew Exercise System
Computer-Controlled Force Generator
The Constant Force Resistive Exercise Unit (CFREU) for Multi-Functional Exercise
A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness
ESPRIT: Exercise Sensing and Pose Recovery Inference Tool
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment
Retrospective analysis of inflight exercise loading and health outcomes
Development of a Muscle Adaptation in Space-flight Simulator ("MASS")
Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Exploring the Relationship between In-Flight Training Load Data and Musculoskeletal Health Outcomes
Enhancing the Efficacy of Musculoskeletal Countermeasures Using Computer Simulation
Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Sweat Rates During Continuous and Interval Aerobic Exercise: Implications for NASA Multipurpose Crew Vehicle (MPCV) Missions
Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration
Biomechanical Analysis of Treadmill Locomotion on the International Space Station
Flywheel/control Bedrest (placeholder)
Exploration Exercise Treadmill Requirements
Efficacy of Orion Flywheel Exercise Training in Ambulatory Subjects (Flywheel Ground Efficacy ? Exploration Exercise)
MA-301: Evaluate an integrated exercise countermeasure system(s) and the potential impact of other physiological countermeasure(s) to protect mission-specific task performance and crew health outcomes.
A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness
Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device (Ferrigno)
Biomechanical Analysis of Treadmill Locomotion on the International Space Station
Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise
Development of a Muscle Adaptation in Space-flight Simulator ("MASS")
Enhancing the Efficacy of Musculoskeletal Countermeasures Using Computer Simulation
ESPRIT: Exercise Sensing and Pose Recovery Inference Tool
Exploring the Relationship between In-Flight Training Load Data and Musculoskeletal Health Outcomes
Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device
Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)
Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity Independent Training Device
Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment
Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)
Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)
Retrospective analysis of inflight exercise loading and health outcomes
Sweat Rates During Continuous and Interval Aerobic Exercise: Implications for NASA Multipurpose Crew Vehicle (MPCV) Missions
Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration
MA-202: Determine whether adjunct or supplementary countermeasures (e.g., nutrition, pharmaceuticals, novel devices, sensorimotor training) improve the efficacy of the exercise countermeasures to protect mission-specific task performance and crew health outcomes.
Gravitational dose and multi-system physiologic response
Alterations in Energy Metabolism Pathways in Skeletal Muscle in Relation to Microgravity Analog and Space Radiation
Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)
Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)
Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration
M1: What is the current state of knowledge regarding exercise performance?
Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
N2: What is the adequate dose range of vitamin D supplementation? (This Gap is now Closed)
Efficacy of Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight
Vitamin D Supplement Evaluation of Dosing Requirements
Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight: Study of Supplementation Protocol and Relationship to Immune System Function
N13: Can renal stone risk be decreased using nutritional countermeasures? (closed)
Data Mining for Incidence of Renal Stone Formation Following Spaceflight
Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)
Space Biochemistry Profile
Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)
Integrated Nutrition: Development and Provision of Functional Foods to Mitigate Bone Loss on ISS Missions
Nutritional Status Assessment: SMO-016E
FN-101: Determine the nutritional requirements that would maintain health and performance for DRMs.
Mars Mass Reduced Planetary Nutritional Requirements Evaluation (Analog)
Restricted Food System (Flight)
Nutritional Requirements Trades (Analog)
The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight
Habitability and Human Factors Assessment in CHAPEA (iSHORT, SHAQ and SHU)
Validation of Mass Reduced Foods (Flight)
Assessing the impact of caffeine and other dietary factors on crew performance and sleep
Maturation Task - Preliminary Food System Risk/Resource Trades
FN-102: Determine the nutrient content, safety, and acceptability of the spaceflight food system (specific to each DRM and associated vehicle constraints).
Food Acceptability, Menu Fatigue, and Aversion on ISS Missions
Food Acceptability Sirius 2021
Culture-based Environmental Monitoring of Crop-based Space Food Systems
Improvement of Shelf Life for Space Food Through Hurdle Approach
Stabilized Foods for Use in Extended Spaceflight: Preservation of Shelf-Life, Nutrient Content and Acceptability
New Crop Testing Legumes Organoleptic and Nutritional Analysis
Microgreens Nutritional Investigation
Microgreens Food Safety Evaluation
Pick and Eat Crop Selection Study
Pick and Eat Salad Crop Testing
Plant Growth 2-ISS
GMO Crops
Deep space Food Storage Validation Gateway
Pick-and-Eat Salad-Crop Productivity, Nutritional Value, and Acceptability to Supplement the ISS Food System
Microbial Database
Maturation Task - Food Storage Limit Requirements to HMTA
FN-302: Validate CM in flight
Validation of Mass Reduced Foods (Flight)
Restricted Food System (Flight)
Maturation Task - Validated Food System
FN-206 Develop Countermeasures: Develop countermeasures either within the food system (e.g., variety, process improvements, crop growth, etc.) or in addition to (e.g., supplementation, fortification) to mitigate decrements in nutritional status, mitigate DRM impacts on health and performance outcomes, and/or risks to food safety, stability, and/or acceptability.
Mars Mass Reduced Planetary Nutritional Requirements Evaluation (Analog)
Countermeasures to decrements identified in Hurdle Approach
Nutritional Requirements Trades (Analog)
Risk of Reduced Crew Health and Performance Due to Hypoxia [inactive]
ExAtm2: We do not know how mild hypobaric hypoxia in combination with other spaceflight environmental factors will impact exercise countermeasures.
ExAtm3: We do not know how mild hypobaric hypoxia in combination with other spaceflight environmental factors will impact the immune system and Oxidative Stress and Damage (OSaD).
Understanding the Impact of Hypobaric Hypoxia and Confinement Stress on Intestinal Immunity and Host-Microbiome Interactions
ExAtm4: We do not know how mild hypobaric hypoxia in combination with other spaceflight environmental factors will impact sleep.
Environmental Factors Associated with Sleep Deficiency During Spaceflight
ExAtm5: We do not know the O2 prebreathe requirements for DCS mitigation from the 8.2/34 environment (shared with DCS5).
ExAtm6: We do not know how hypobaric hypoxia affects medical equipment.
ExAtm7: We do not know how hypobaric hypoxia affects food preparation.
Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.
Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance (Stenger)
Microgravity Associated Compartmental Equilibration (Dulchavsky)
Fluid Distribution before, during and after Prolonged Space Flight (Hargens)
Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)
Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome (Zanello)
VIIP Simulations of CSF, Hemodynamics and Ocular Risk (Ethier)
Investigating Structure and Function of the Eye - ISS (Macias)
Markers of Vascular Risks Associated with Spaceflight Associated Neuro-ocular Syndrome - ISS (Hein)
Changes of the optic nerve dura mater in astronauts and SANS (Ethier)
Investigating Long-term Structural and Functional Changes in the Eye and Brain after Spaceflight
Prospective Observational Study of Ocular Health in ISS Crews (Macias)
Mapping by VESGEN of Blood Vessels in the Human Retina for Improved Understanding of Visual Impairments and Increased Intracranial Pressure (Parsons-Wingerter)
SD-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals [SD-OCT ANALYSIS/PASS/COMPLETED
Association of Diffusion Tensor Imaging Parameters of Optic Tracts and Cerebral White Matter Tracts with Visual Impairment and Structural Changes of the Eyes and Optic Nerves in Long-Duration Microgravity Exposure [DTI/RIASCOS]
Retrospective Pre and postflight measurement of cerebrospinal fluid (CSF) dynamics [MR-ICP CSF DYNAMICS RETROSPECTIVE/ALPERIN]
Effects of Long Duration Spaceflight on Venous and Arterial Compliance in Astronauts [VASCULAR COMPLIANCE/PLATTS]
Pre & Postflight MRV review (central venous congestion) [VIIP MRV/RIASCOS/COMPLETED]
Pilot study to evaluate a novel non-invasive technology to estimate peripheral and central venous pressure
A data mining project to identify cardiovascular related factors that may contribute to changes in visual acuity within the astronaut corps
rVisual Impairment and Intracranial Pressure Project Data Mining
Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations Evidence Report
Role of the Cranial Venous Circulation in Microgravity-Associated Visual Changes [CRANIAL VENOUS CIRCULATION/BUCKEY]
Ocular Imaging-Artemis
Brain-Related Assessments for Investigating the Neurophysiology of SANS
Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Long-Term Brain Structural and Functional Consequences of Spaceflight
Maturation Task - SANS Standards for maintaining inflight health to OCHMO
Maturation Task - SANS Standards for Long Term Health to OCHMO
The Long-Term Consequences of Spaceflight on Brain and Eye Health (Bershad)
MiniOCT Demo-ISS
SANS-102: Determine the relationship between the fluid shifts-induced ocular changes and fluid shifts in the CNS, including whether elevated intracranial pressure or brain edema play a role.
Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution (Roberts)
Impact of +Gz and -Gz induced fluid shifts on ocular and cerebral parameters during simulated Orion re-entry.
Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT]
Effects of Microgravity on Intracranial Pressure [MICROGRAVITY ICP/LEVINE]
Brain Gene Expression Signatures from Cerebrospinal Fluid Exosome RNA Profiling [CSF EXOSOME GROUND/ZANELLO]
Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)
Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome (Zanello)
Markers of Vascular Risks Associated with Spaceflight Associated Neuro-ocular Syndrome - ISS (Hein)
Brain-Related Assessments for Investigating the Neurophysiology of SANS
Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Long-Term Brain Structural and Functional Consequences of Spaceflight
Maturation Task - SANS Standards for Long Term Health to OCHMO
GLP1-RA as SANS rescue CM
SANS-103: Determine whether ground-based induced fluid shifts lead to ocular manifestations.
SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD]
Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)
Brain-Related Assessments for Investigating the Neurophysiology of SANS
SANS-104: Determine whether ocular manifestations can be induced by fluid shifts in animal models and whether this model can be used for more detailed mechanistic insights.
A gene expression and histological approach to the study of cerebrospinal fluid production and outflow in rats (Zanello)
Effects of microgravity on ocular vascular hydrodynamics - ISS (Zawieja)
Head-down tilt as a model for intracranial and intraocular pressures, and retinal changes during spaceflight (Fuller)
Evaluation of Hindlimb Suspension as a Model to Study Ophthalmic Complications in Microgravity: Ocular Structure and Function and Association with Intracranial Pressure (Zanello)
Hindlimb suspension (HS) as an analog model of ocular alterations associated with cephalad fluid shifts: resveratrol as a countermeasure
SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.
Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE]
Comparing Globe Distortions Following Head-Down Bed Rest to those Measured in Astronauts in Short and Long-Duration Spaceflights [Thirty-day CO2 Bedrest/ALPERIN/ACTIVE]
Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE]
Measuring Transcutaneous Partial Pressure of Carbon Dioxide (PCO2) to Estimate Arterial PCO2 during Spaceflight
Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function
SANS-202: Determine if genetic/metabolic/anatomic dispositions and biomarkers, and sex differences have a contributing role in the development of ocular manifestations.
VIIP and One-Carbon Metabolism: Expanded Polymorphism Evaluation and Polycystic Ovary Syndrome Pilot Study (Smith)
SANS Data Integration using IMPALA
Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)
Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH]
Are Medications Involved in Vision and Intracranial Pressure Changes Seen in Spaceflight? [VIIP PHARM/WOTRING]
A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight (Tavakkoli)
B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)
Exploring Endothelial Function Risk Factors and Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest
B Complex: A Nutraceutical SANS Countermeasure
SANS-203: Determine if radiation has a contributing role in the development of ocular manifestations.
Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits (Mao)
Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135
Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes
SANS Larger Animal HLS + Radiation Study - Lab
SANS-204: Determine if sleep/glymphatics has a contributing role in the development of ocular manifestations.
Microgravity-driven Optic Nerve/Sheath Remodeling Simulator [OPHTHALMIC CHANGES MODELING/ETHIER]
Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Assess Glymphatic Changes for Spaceflight
Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function
SANS-304: Identify and evaluate candidate countermeasure(s) in a space flight analog
Optical System for Monitoring Net Ocular Blood Flow (Mujat)
Mobile Gravity Suit, An Integrative Countermeasure Device (Petersen)
Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)
A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight (Tavakkoli)
Mechanical and gravitational countermeasures to ocular changes during strict head-down tilt bedrest (Macias)
Exercise Countermeasure to Prevent Ocular Structural and Functional Changes in a Terrestrial Model of SANS - Bedrest (Huang)
Ophthalmic and intracranial structural changes in head-down tilt bedrest: potential countermeasures and comparison to SANS findings in astronauts (Martin)
Brain-Related Assessments for Investigating the Neurophysiology of SANS
Validation of a GLP-1 pharmaceutical as a countermeasure to SANS - Bedrest
Combo SANS Countermeasures-Bedrest
SANS-403: Test candidate countermeasure(s) in a space flight environment
Mitigating headward fluid shifts and vision impairment with thigh cuffs during spaceflight - ISS
Lower Body Negative Pressure Device Flight Demo - ISS
B Complex: A Nutraceutical SANS Countermeasure
GLP1-RA as SANS rescue CM
SANS-501: Validate/optimize integrated countermeasures in the spaceflight environment
SANS Integrated Countermeasures-LEO
Maturation Task - SANS CM to SCLT/HMTA
Space Radiation
Risk of Radiation Carcinogenesis
Cancer 11: What are the most effective shielding approaches to mitigate cancer risks? (closed: transferred to NASA AES).
Measurements and Transport Phase 2 Physics Project
Quantum Multiple Scattering Model of Heavy Ion Fragmentation (QMSFRG)
Space Radiation Risk Assessment Project-Cucinotta
Update of the Nuclear Fragmentation Cross Section Code NUCFRG2
Fast Neutron Dosimeter for the Space Environment
Molecular and cellular effects of heavy ion fragmentation due to shielding
Spectroscopic Dosimeter
Integrated Radiation Analysis and Design Tools
Biophysics Phase 1
Cancer 12: What quantitative models, numerical methods, and experimental data are needed to accurately describe the primary space radiation environment and transport through spacecraft materials and tissue to evaluate dose composition in critical organs for mission relevant radiation environments (ISS, Free-space, Lunar, or Mars)? (closed: transferred to NASA AES).
Measurements and Transport Phase 2 Physics Project
Quantum Multiple Scattering Model of Heavy Ion Fragmentation (QMSFRG)
Space Radiation Risk Assessment Project-Cucinotta
Update of the Nuclear Fragmentation Cross Section Code NUCFRG2
Integrated Radiation Analysis and Design Tools
Biophysics Phase 1
Cancer 13: What are the most effective approaches to integrate radiation shielding analysis codes with collaborative engineering design environments used by spacecraft and planetary habitat design efforts? (closed: transferred to NASA AES).
Integrated Radiation Analysis and Design Tools
Biophysics Phase 1
Cancer-202: Evaluate the contribution of genetic background/diversity on carcinogenesis risk.
Blood-based multi-scale model for cancer risk from GCR in genetically diverse populations
The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract
The impact of human spaceflight on clonal hematopoiesis
NSCOR: Mechanisms Underlying the Risk of HZE Particle-Induced Solid Tumor Development
NASA Specialized Center of Research on Carcinogenesis
NSCOR: NASA Specialized Center of Research on Radiation Carcinogenesis
Mechanistic Study of the Risk of Low Doses of HZE Particles on Human Cell Pre-Malignant Transformation
A mechanistic investigation of space radiation-induced carcinogenesis - NNX12AB88G
Physical and Biological Modulators of Space Radiation Carcinogenesis: Mechanistically - Based Model Development for Space Radiation Risk Assessment
Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk
Evaluation of Sex-Specific Differences in Lung Cancer Radiation Risks and Recommendations for Use in Transfer Models (NCRP)
Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development
iPSCs Cancer
TRRaC Radiation Induced Carcinogenesis Biomarkers
Cancer-203: Evaluate the tissue-specific risks of space radiation exposure on cancer outcomes.
Induction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms
Ovarian cancer and space radiation
Oxidative Stress and the Cancer Risk of Space Radiation
Space radiation-induced persistent estrogenic response and risk of breast cancer development
Determining Gender Differences in the Incidence of Lung Adenocarcinoma After Space Radiation Exposure
Mechanistic Analysis of Particle Radiation-Induced Carcinogenesis Using Validated Mouse Glioma Models
Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk
Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development
NASA Specialized Center of Research on Carcinogenesis
The Impact of Spaceflight and Radiation on Clonal Hematopoiesis
iPSCs Cancer
TRRaC Radiation Induced Carcinogenesis Biomarkers
Cancer-103: Determine the effects of radiation quality on cancer initiation, promotion, and progression.
Induction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms
Molecular characterization of transmissible chromosome aberrations produced by ions of intermediate and high atomic number
Oxidative Stress and the Cancer Risk of Space Radiation
Physical and Biological Modulators of Space Radiation Carcinogenesis: Mechanistically - Based Model Development for Space Radiation Risk Assessment
The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract
Space radiation exposure and risk mediated by clonal hematopoiesis.
Dose Rate Effects and GCR Simulation in Cancer Relevant Systems
Simulation of GCR-Induced Harderian Gland and Lung Tumorigenesis
Mechanistic Analysis of Particle Radiation-Induced Carcinogenesis Using Validated Mouse Glioma Models
Molecular Characterization of Transmissible Chromosome Aberrations Produced By Ions of Intermediate and High Atomic Number (directed task).
Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk
Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development
Space radiation-induced persistent estrogenic response and risk of breast cancer development
Multi-model Ensemble Risk Assessment Maturation
Protracted exposure to NASA's GCR-Simulator: Cytogenetic validation and beam time optimization
Ovarian cancer and space radiation
Multi-Model Ensemble Risk Assessment
Mouse Models of Cancer Risk and Prevention from Space Radiation
Galactic Cosmic Ray Simulator and Mitigation Project
Determining Gender Differences in the Incidence of Lung Adenocarcinoma After Space Radiation Exposure
NASA Specialized Center of Research on Carcinogenesis
LaRC-MERA Multimodel Ensemble Risk
Cancer-104: Determine the effects of radiation dose and dose-rate on cancer initiation, promotion and progression.
Oxidative Stress and the Cancer Risk of Space Radiation
Simulation of GCR-Induced Harderian Gland and Lung Tumorigenesis
Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development
Multi-model Ensemble Risk Assessment Maturation
Protracted exposure to NASA's GCR-Simulator: Cytogenetic validation and beam time optimization
Multi-Model Ensemble Risk Assessment
Mouse Models of Cancer Risk and Prevention from Space Radiation
Space radiation exposure and risk mediated by clonal hematopoiesis.
NASA Specialized Center of Research on Carcinogenesis
Dose Rate Effects and GCR Simulation in Cancer Relevant Systems
Cancer-204: Evaluate the sex-specific risks of space radiation exposure on cancer outcomes.
Evaluation of Sex-Specific Differences in Lung Cancer Radiation Risks and Recommendations for Use in Transfer Models (NCRP)
Mapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification
Space radiation-induced persistent estrogenic response and risk of breast cancer development
Multi-model Ensemble Risk Assessment Maturation
Ovarian cancer and space radiation
Multi-Model Ensemble Risk Assessment
Determining Gender Differences in the Incidence of Lung Adenocarcinoma After Space Radiation Exposure
iPSCs Cancer
The Impact of Chronodisruption on Space Radiation-Induced Gene Signatures
TRRaC Radiation Induced Carcinogenesis Biomarkers
Cancer-303: Identify early surrogate biomarkers that correlate with cancer, pre-malignancy, or the hallmarks of cancer.
Induction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms
Molecular characterization of transmissible chromosome aberrations produced by ions of intermediate and high atomic number
Oxidative Stress and the Cancer Risk of Space Radiation
Physical and Biological Modulators of Space Radiation Carcinogenesis: Mechanistically - Based Model Development for Space Radiation Risk Assessment
Predictive Biomarkers for Space Radiation Induced Cancer and Cardiovascular Injury Risk Assessment
Protracted exposure to NASA's GCR-Simulator: Cytogenetic validation and beam time optimization
The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract
Epigenetic state modulation of radiation-induced DNA damage: Nanoscale modeling and validation.
Molecular Characterization of Transmissible Chromosome Aberrations Produced By Ions of Intermediate and High Atomic Number (directed task).
Mapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification
Effect of GCR exposure on the functional status of the DNA repair machinery and its contribution to cancer risk
Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development
Ovarian cancer and space radiation
Multi-Model Ensemble Risk Assessment
Determining Gender Differences in the Incidence of Lung Adenocarcinoma After Space Radiation Exposure
Space radiation exposure and risk mediated by clonal hematopoiesis.
NASA Specialized Center of Research on Carcinogenesis
Dose Rate Effects and GCR Simulation in Cancer Relevant Systems
The Impact of Spaceflight and Radiation on Clonal Hematopoiesis
Assessing the individual-specific carcinogenic impact of exposure to space radiation environments in astronauts using ultra-accurate Duplex Sequencing
The Impact of Chronodisruption on Space Radiation-Induced Gene Signatures
TRRaC Radiation Induced Carcinogenesis Biomarkers
Cancer-304: Identify and/or develop strategies for accelerated countermeasure development.
Mechanistic Analysis of Particle Radiation-Induced Carcinogenesis Using Validated Mouse Glioma Models
TRRaC Radiation Induced Carcinogenesis Biomarkers
Cancer-402: Identify and/or develop monitoring tools to support spaceflight research, long-term health surveillance, and countermeasure implementation.
The Impact of Spaceflight and Radiation on Clonal Hematopoiesis
Assessing the individual-specific carcinogenic impact of exposure to space radiation environments in astronauts using ultra-accurate Duplex Sequencing
Cancer-502: Systematically identify safe and effective countermeasures to reduce radiation carcinogenesis.
Countermeasures against adverse effects of space radiation
Countermeasures to Radiation Induced Cardiomyopathy
Cancer-503: Validate identified countermeasures to reduce radiation carcinogenesis risks in advanced biological model systems.
Cancer-602: Operationalize identified and validated interventional countermeasures for space flight.
Cancer-603: Operationalize identified monitoring/preventative countermeasures.
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