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Ground Based Studies in Space Radiobiology
08.05.08
NASA's Human Research Program will fund nine proposals from six states to investigate questions about the affects of space radiation on human explorers. The selected proposals from researchers in California, Colorado, Georgia, Maryland, New York and Texas have a total value of approximately $13 million.

The ground-based studies will address the impact of space radiation on astronaut health. Research areas will include risk predictions for cancer and models for potential damage to the central nervous system. Winners are listed below:
  • John Fike, University of California, San Francisco, Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis
  • Janice Pluth, UC Berkeley, Elucidating the Relationship Between the Effects of Various Radiation Qualities and Cancer Development Processes using Novel Flow-based Assays
  • Charles Limoli, University of California, Irvine, Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei
  • Chuan-Yuan Li, University of Colorado Health Sciences Center, A mechanistic investigation of space radiation-induced carcinogenesis
  • Huichen Wang,Emory University, Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation
  • Robert Hienz, Johns Hopkins Medical Institutions, Cognitive/Behavioral, Sensory, & Motor Changes Induced by SPE and GCR Irradiations
  • Sally Amundson, Columbia University, HZE-induced mammary cancer development processes in murine and "humanized" models, and their influence on radiation quality functions
  • M. Kerry O'Banion, University of Rochester, Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure
  • Jerry Shay, UT Southwestern Medical Center, Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis