NASA has selected 11 research proposals representing eight states and 11 institutions received in response to NASA Research Announcement NNJ13ZSA001N, "Ground-Based Studies in Space Radiobiology." Proposals were openly solicited from academia, industry and government laboratories and were judged for scientific merit by non-NASA scientific and technical experts.
These studies will help enable the human exploration of space without exceeding limiting risks from space radiation. The research will use new experimental approaches in understanding space radiation risks of cancer, heart and circulatory disease and long-term cognitive function.
The selected proposals will receive a total amount of approximately $13.8 million during a one to four-year period.
- Dennis Kucik, MD/PhD, University of Alabama at Birmingham, “Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis”
- Susanna Rosi, PhD, University of California, San Francisco, “The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation”
- Andrew Wyrobek, PhD, Lawrence Berkeley National Laboratory, “Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation”
- Polly Chang, PhD, SRI International, “Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain”
- Ulrike Luderer, PhD, University of California Irvine, “Charged Particle Effects on the Ovary”
- David Kirsch, MD/PhD, Duke University, “Defining the Role of miR-182 in HZE-Induced Tumorignesis”
- Lubomir Smilenov, PhD, Columbia University, “The Effect of High LET Radiation on Differentiation and Tumorigenesis in the Human Hematopoietic System: Modeling in vitro and in vivo for Risk Assessment”
- Stanton Gerson, PhD, Case Western Reserve University, “Contribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis”
- Mitchell Turker, PhD, Oregon Health & Science University, “The Relation Between Mutagenesis and Genomic Instability After Particle Exposure in vivo”
- Bradford Loucas, PhD, University Of Texas, Galveston, “The Contribution of Delta Rays to the Chromosome Aberration Dose Response in Human Cells Irradiated with HZE Particles of Different Energy but the Same LET”
- Richard Britten, PhD, Eastern Virginia Medical School, “Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition.”