Skeletal (Bone) Changes

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Laboratory Lead: Linda C. Shackelford, M.D.
Discipline Lead: Jean D. Sibonga, Ph.D.

Current Investigations:

• Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight (Short Title: Bone Epidemiologic Analysis)
  PI: Shreyasee Amin, M.D.
  Ground
• Rapid Measurements of Bone Loss using Tracer-less Calcium Isotope Analysis of Blood and Urine (Short Title: Calcium Isotope Study)
  PI: Ariel Anbar, Ph.D.
  Ground
• Contributors to Long-Term Recovery of Bone Strength Following Exposure to Microgravity (Short Title: Bone Strength Recovery)
  PI: Harry Hogan, Ph.D.
  Ground
• Monitoring of Bone Loss Bio-Markers in Human Sweat: A Non-invasive, Time Efficient Means of Monitoring Bone Resorption Markers Under Micro and Partial Gravity Loading Conditions (Short Title: Sweat)
  PI: Mark Clarke, Ph.D.
  Ground
• Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure (Short Title: Musculoskeletal Recovery)
  PI: Stefan Judex, Ph.D.
  Ground
• Risk of Intervertebral Disc Damage after Prolonged Space Flight (Short Title: IVD post-spaceflight)
  PI: Alan Hargens, Ph.D.
  Flight
• Sonographic Astronaut Vertebral Examination (Short Title: Sonogram - Vertebral)
  PI: Scott Dulchavsky, Ph.D.
  Ground
• Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss (Short Title: Bisphosphonates SMO)
  PI: Adrian LeBlanc, Ph.D.
  Flight
• Serum Sclerostin Measurements in Bedrest and Long Duration Astronauts (Short Title: Sclerostin Bedrest)
  PI: Jean Sibonga, Ph.D.
  Ground

Click on the highlighted link for the abstract or full text article (if available). You may have additional access to the full text through your institution by clicking on the icons displayed in the link.

Publications:

• Genc, KO, Gopalakrishnan R, Kuklis MM, Maender CC, Rice AJ, Bowersox KD, Cavanagh PR. Foot forces during exercise on the International Space Station. J Biomech. 43(15):3020-7, 2010.
• Holguin N, Judex S. Rat intervertebral disc health during hindlimb unloading: brief ambulation with or without vibration. Aviat Space Environ Med., 81(12):1078-84, 2010.
• Carpenter RD, LeBlanc AD, Evans H, Sibonga JD, Lang TF. Long-term changes in the density and structure of the human hip and spine after long- duration spaceflight. Acta Astronautica. 67(1-2): 71-81, 2010.
• Cavanagh PR, Genc KO, Gopalakrishnan R, Kuklis MM, Maender CC, Rice AJ. Foot forces during typical days on the international space station. J Biomech. 43(11):2182-8, 2010.
• Fitts RH, Trappe SW, Costill DL, Gallagher PM, Creer AC, Colloton PA, Peters JR, Romatowski JG, Bain JL, Riley DA. Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres. J Physiol. 588(Pt 18):3567-92, 2010.
• Lang TF. Quantitative computed tomography. Radiol Clin North Am. 48(3):589-600, 2010.
• Ozcivici E, Luu YK, Rubin CT, Judex S. Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulation. PLoS One. 5(6):11178, 2010.
• Ozcivici E, Luu YK, Adler B, Qin YX, Rubin J, Judex S, Rubin CT. Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol. 6(1):50-9, 2010.
• Zhao Q, Li W, Li C, Chu PW, Kornak J, Lang TF, Fang J, Lu Y. A statistical method (cross-validation) for bone loss region detection after spaceflight. Australas Phys Eng Sci Med. 33(2):163-9, 2010.
• Cavanagh PR, Gopalakrishnan R, Rice AJ, Genc KO, Maender CC, Nystrom PG, Johnson MJ, Kuklis MM, Humphreys BT. An ambulatory biomechanical data collection system for use in space: design and validation. Aviat Space Environ Med. 80(10):870-81, 2009.
• Holguin N, Muir J, Rubin C, Judex S. Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest. Spine J. 9(6):470-7, 2009.
• Judex S, Gupta S, Rubin C. Regulation of mechanical signals in bone. Orthodont Craniofac Res. 12(2):94-104, 2009.
• Saeed I, Carpenter RD, LeBlanc AD, Li J, Keyak JH, Sibonga JD, Lang TF. Quantitative computed tomography reveals the effects of race and sex on bone size and trabecular and cortical bone density. J Clin Densitom. 12(3):330-6, 2009.
• Trappe S, Costill D, Gallagher P, Creer A, Peters JR, Evans H, Riley DA, Fitts RH. Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J Appl Physiol. 106(4):1159-68, 2009.
• Whitson PA, Pietrzyk RA, Jones JA, Nelman-Gonzalez M, Hudson EK, Sams CF. Effect of potassium citrate therapy on the risk of renal stone formation during spaceflight. J Urol. 182(5):2490-6, 2009.
• Squire M, Brazin A, Keng Y, Judex S. Baseline bone morphometry and cellular activity modulate the degree of bone loss in the appendicular skeleton during disuse. Bone. 42(2):341-9, 2008.
• LeBlanc AD, Spector ER, Evans HJ, Sibonga JD. Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact. 7(1):33-47, 2007.
• Lublinsky S, Ozcivici E, Judex S. An automated algorithm to detect the trabecular-cortical bone interface in micro-computed tomographic images. Calcif Tissue Int. 81(4):285-93, 2007.
• Miller LM, Little W, Schirmer A, Sheik F, Busa B, Judex S. Accretion of bone quantity and quality in the developing mouse skeleton. J Bone Miner Res. 22(7):1037-45, 2007.
• Pietrzyk RA, Jones JA, Sams CF, Whitson PA. Renal stone formation among astronauts. Aviat Space Environ Med. 78(4 Suppl):A9-13, 2007.
• Sibonga JD, Evans HJ, Sung HG, Spector ER, Lang TF, Oganov VS, Bakulin AV, Shackelford LC, LeBlanc AD. Recovery of spaceflight-induced bone loss: bone mineral density after long-duration missions as fitted with an exponential function. Bone. 41(6):973-8, 2007.
• Lang TF, LeBlanc AD, Evans HJ, Lu Y. Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res. 21(8):1224-30, 2006.

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