Follow this link to skip to the main content

NASA - National Aeronautics and Space Administration

  • NASA Home
  •     >    Centers
  •     >    Johnson Home
  •     >    HH&P
  •     >    BRES
  •     >    Project
    • Send
    • Follow this link to Share This Page
      Share

    NxPCM

    Immunological Changes


    Laboratory Lead: Clarence Sams, Ph.D.
    Discipline Lead: Brian E. Crucian, Ph.D.

    Current Investigations:
    • Validation of Procedures for Monitoring Crewmember Immune Function (Short Title: Integrated Immune)
      PI: Clarence Sams, Ph.D.
      Flight
    • Consequences of Long-term Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment (Short Title: CHOICE)
      PI: Clarence Sams, Ph.D.
      Ground

    Click on the highlighted link for the abstract or full text article (if available). You may have additional access to the full text through your institution by clicking on the icons displayed in the link.

    Publications:

    • Crabbé A, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Pierson DL, Stefanyshyn-Piper H, Nickerson CA. Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. Appl Environ Microbiol. 77(4):1221-30, 2011.
    • Pierson DL, Mehta SK, Gilden D, Cohrs RJ, Nagel MA, Schmid DS, Tyring SK. Varicella zoster virus DNA at inoculation sites and in saliva after Zostavax immunization. J Infect Dis. 201(11):1542-5, 2011.
    • Stowe RP, Kozlova EV, Sams CF, Pierson DL, Walling DM. Latent and lytic Epstein-Barr virus gene expression in the peripheral blood of astronauts. J Med Virol. 83(6):1071-7, 2011.
    • Stowe RP, Sams CF, Pierson DL. Adrenocortical and immune responses following short- and long-duration spaceflight. Aviat Space Environ Med. 82(6):627-634, 2011.
    • Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA. Organotypic 3D cell culture models: Using the rotating wall vessel to study host-pathogen interactions. Nat Rev Microbiol. 8(11):791-801, 2010.
    • Crucian B and Sams C. Immune system dysregulation during spaceflight: clinical risk for exploration-class missions. J Leukoc Biol. 86(5):1017-8, 2009.
    • Satyaprakash AK, Tremaine AM, Stelter AA, Creed R, Ravanfar P, Mendoza N, Mehta SK, Rady PL, Pierson DL, Tyring SK. Viremia in Acute Herpes Zoster. J Infect Dis. 200(1):26-32, 2009.
    • Cohrs RJ, Mehta SK, Schmid DS, Gilden DH, Pierson DL. Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts. J Med Virol. 80(6):1116-22, 2008.
    • Crucian BE, Stowe RP, Pierson DL, Sams CF. Immune system dysregulation following short- vs long-duration spaceflight. Aviat Space Environ Med. 79(9):835-43, 2008.
    • Kaur I, Simons ER, Kapadia AS, Ott CM, Pierson DL. Effect of spaceflight on ability of monocytes to respond to endotoxins of gram-negative bacteria. Clin Vaccine Immunol. 15(10):1523-8, 2008.
    • Mehta SK, Tyring SK, Gilden DH, Cohrs RJ, Leal MJ, Castro VA, Feiveson AH, Ott CM, Pierson DL. Varicella-zoster virus in the saliva of patients with herpes zoster. J Infect Dis. 197(5):654-7, 2008.
    • Stowe RP, Yetman DL, Storm WF, Sams CF, Pierson DL. Neuroendocrine and immune responses to 16-day bed rest with realistic launch and landing G profiles. Aviat Space Environ Med. 79(2):117-122, 2008.
    • Wilson JW, Ott CM, Quick L, Davis R, Höner zu Bentrup K, Crabbé A, Richter E, Sarker S, Barrila J, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Shah M, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, CdeBaca A, Narayan S, Benjamin J, Goulart C, Rupert M, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Porter MD, Pierson DL, Smith SM, Mergeay M, Leys N, Stefanyshyn-Piper HM, Gorie D, Nickerson CA. Media ion composition controls regulatory and virulence response of Salmonella in spaceflight. PLoS ONE. 3(12):e3923, 2008.
    • Mehta SK, Pierson DL. Reactivation of latent herpes viruses in cosmonauts during a Soyuz taxi mission. Microgravity Science and Technology 19(5-6):215-8, 2007.
    • Nauman EA, Ott CM, Sander E, Tucker DL, Pierson D, Wilson JW, Nickerson CA. Novel quantitative biosystem for modeling physiological fluid shear stress on cells. Appl Environ Microbiol. 73(3):699-705, 2007.
    • Stowe RP, Kozlova EV, Yetman DL, Walling DM, Goodwin JS, Glaser R. Chronic herpesvirus reactivation occurs in aging. Exp Gerontol. 42(6):563-70, 2007.
    • Wilson JW, Ott CM, Höner zu Bentrup K, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah M, Kilcoyne M, Joshi L, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, Goulart C, Rupert M, Stodieck L, Stafford P, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen P, Baker-Coleman C, Hammond T, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA. Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. Proc Natl Acad Sci U S A. 104(41):16299-304, 2007.


    << Back to NxPCM Main Page