+ Tissue Analogues

    Tissue Analogues

    About the Disease Modelling and Tissue Analogues Laboratory

    Tissue Analogues Tissue Analogues
    The Disease Modelling and Tissue Analogues Laboratory (DMTAL) provides to the Agency three-dimensional (3D) tissue organoid analogue capabilities and the testing of normal and neoplastic human and animal tissues subjected to a variety of biological, physical, and environmental stressors. These stressors include but are not limited to particle toxicity assessment (dust), modelling of human viral and microbial infectivity (re-expressed viruses and bacterial infections), subjection of normal human tissues to various types and intensities of space radiation and modelling aspects of microgravity and non-ionizing radiation. Over the past 15 years the laboratory has developed systems biology approaches to disease states and conditions associated with space habitation and provides the capability to assess uniquely human combinatorial effects of space related stressors. Analyses of these stressors and conditions are translated into cutting edge scientific data in the forms of advanced genomics, proteomics, and metabolomics. Currently, the DMTAL is activity involved with the assessment of potential countermeasures to address the loss of human bone mass in space associated disease states, rapid repair of bone in the space environment, the study of viral re-expression as relates to astronaut health risks, and the consequences of combinatorial space biological events including space radiation. Additionally, DMTAL is engaged in the development of on-orbit research and diagnostic analyses POC (point–of-care) capabilities which will reduce or in some cases eliminate the need for sample return from space platforms or planetoids.