Publications

+ Immunology

    Immunology

    About Immunology



    Immunology - Shuttle Immunology Shuttle Support
    Immunology is responsible for investigating the effects of space flight on various aspects of human physiology. The 2 primary areas of research deal with the effects of space flight on the human immune system and increased risk of kidney stone formation during flight because of bone demineralization. The goal of the CML is to investigate the mechanisms responsible for these physiologic changes so that appropriate countermeasures can be developed for future exploration-class space missions. Laboratory personnel conduct ground-based research and spaceflight experiments onboard the Space Shuttle and the International Space Station. Laboratory personnel also perform conceptual design and prototype development for specific flight hardware. Laboratory personnel recently initiated design and validation of a prototype spaceflight-compatible flow cytometer for in- flight medical and research support.

    Immunology - Graph Detection of Activated T Cells
    Bioastronautics team scientists comprise the core research staff of the CML. In addition, postdoctoral associates, visiting scientists, graduate students and high school students routinely perform rotations of varying lengths in the laboratory. The laboratory currently possesses an impressive array of sophisticated research equipment, including a clinical flow cytometer, fluorescent microscopes, a spectrophotometer and a high performance liquid chromatograph. Recent upgrades to the laboratory have included a six-color research flow cytometer, a confocal microscope, and an environmental scanning electron microscope.

    Immunology - ISS Immunology ISS Support
    Specific research currently conducted includes a pre- and postflight immune assessment of Shuttle and ISS crewmembers, the investigation of spaceflight effects (and microgravity model systems) on T cell signal transduction, and determining the risk of the renal stone formation to crewmembers during long-duration space flight. These studies support the multidisciplinary assessment of crew health risks and the development of potential countermeasure to mitigate these risks. Laboratory personnel also performs microgravity studies and hardware validation onboard the NASA C-9 parabolic flight research aircraft.

    Immunology - Microscopic Tubulin Polarization
    Laboratory personnel have published research findings in many reputable scientific journals including: FASEB Journal, Journal of the Leukocyte Biology, Cytometry, Journal of Gravitational Physiology, Journal of Interferon and Cytokine Research, Mineral Electrolyte and Metabolism and Journal of the American Society of Nephrology. In addition, they routinely present data at both national and international scientific meetings.

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